microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34C Gene

RNA type for MIR34C Gene

miRNA

Aliases for MIR34C Gene

External Ids for MIR34C Gene

Previous HGNC Symbols for MIR34C Gene

  • MIRN34C

Previous GeneCards Identifiers for MIR34C Gene

  • GC11P110906
  • GC11P110909
  • GC11P111384
  • GC11P111514
  • GC11P111517
  • GC11P111559
  • GC11P111565
  • GC11P111571
  • GC11P111579
  • GC11P111520
  • GC11P111523
  • GC11P111526
  • GC11P111529
  • GC11P111532
  • GC11P111535
  • GC11P111538
  • GC11P111548
  • GC11P111582

Summaries for MIR34C Gene

Entrez Gene Summary for MIR34C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34C Gene

MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34C include Thyroid Gland Anaplastic Carcinoma and Ovarian Cancer. Among its related pathways are Apoptosis and survival Caspase cascade and MicroRNAs in cancer.

Rfam classification for MIR34C Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34C Gene

Genomics for MIR34C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR34C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111514 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.7 +1.5 1463 0.6 SIN3A BMI1 RFX1 ELF3 PRDM10 CTCF PKNOX1 HOATZ BTG4 MIR34B MIR34C piR-39656 ENSG00000254980 LAYN
GH11J111512 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.7 -0.3 -337 2.2 CTCF GLIS2 POLR2A EZH2 ZNF335 ZBTB26 BTG4 HOATZ MIR34B MIR34C piR-39656 PPP2R1B LAYN LOC728196 ENSG00000254980 POU2AF1
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 +252.6 252578 3.3 IKZF1 SSRP1 ZNF580 POLR2A NFIC ZIC2 YY1 SMAD5 SIN3A ZNF639 PPP2R1B HSALNG0087137 lnc-SIK2-3 ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 HOATZ
GH11J111375 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 9.2 -135.0 -134951 5.1 BCLAF1 ZNF207 POLR2A IRF4 EBF1 CBFB SMARCA5 MAX TAF1 BHLHE40 POU2AF1 lnc-BTG4-3 COLCA1 COLCA2 ENSG00000255093 BTG4 HOATZ MIR34B MIR34C HSALNG0087098
GH11J111776 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 9.8 +264.4 264442 2.7 ZNF654 CEBPA YY1 MXD4 CTCF REST ZNF592 TRIM22 KMT2B KDM6A PPP2R1B ENSG00000254990 HSALNG0087139 SIK2 ENSG00000255093 POU2AF1 BTG4 HOATZ MIR34B MIR34C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR34C Gene

Latest Assembly
chr11:111,513,438-111,513,517
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,384,164-111,384,240
(GRCh37/hg19 by Entrez Gene)
Size:
77 bases
Orientation:
Plus strand

chr11:111,384,164-111,384,240
(GRCh37/hg19 by Ensembl)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR34C Gene

Genes around MIR34C on UCSC Golden Path with GeneCards custom track
MIR34C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR34C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34C Gene

Proteins for MIR34C Gene

Post-translational modifications for MIR34C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34C Gene

Domains & Families for MIR34C Gene

Gene Families for MIR34C Gene

genes like me logo Genes that share domains with MIR34C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34C Gene

Function for MIR34C Gene

Phenotypes From GWAS Catalog for MIR34C Gene

CRISPR products for research

miRNA for MIR34C Gene

miRTarBase miRNAs that target MIR34C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR34C Gene

Localization for MIR34C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR34C gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34C Gene

Pathways & Interactions for MIR34C Gene

genes like me logo Genes that share pathways with MIR34C: view

Gene Ontology (GO) - Biological Process for MIR34C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 23047694
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR34C Gene

Drugs & Compounds for MIR34C Gene

No Compound Related Data Available

Transcripts for MIR34C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34C Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00002C7B2B_9606 miRNA 23 6

RefSeq: NR_029840,

LncBase: hsa-miR-34c-5p,

miRBase: MIMAT0000686,

MirGeneDB: Hsa-Mir-34-P2b_5p,

TarBase: hsa-miR-34c-5p,

ENA: LM379206.1:1..23:ncRNA, LM608670.1:13..35:ncRNA,

URS00002C7C59_9606 miRNA 22 6

RefSeq: NR_029840,

LncBase: hsa-miR-34c-3p,

miRBase: MIMAT0004677,

MirGeneDB: Hsa-Mir-34-P2b_3p,

TarBase: hsa-miR-34c-3p,

ENA: LM380341.1:1..22:ncRNA, LM608670.1:46..67:ncRNA,

URS000075E7C8_9606 precursor_RNA 77 4

RefSeq: NR_029840,

Ensembl: ENST00000384831 (view in UCSC) ,

miRBase: MI0000743,

ENA: LM608670.1:1..77:precursor_RNA,

URS00001DFE3F_9606 pre_miRNA 80 1

Rfam: RF00456,

URS0001BC40B6_9606 pre_miRNA 80 1

Rfam: RF00456,

MIR34C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR34C Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34C Gene

No ASD Table

Relevant External Links for MIR34C Gene

GeneLoc Exon Structure for
MIR34C

Expression for MIR34C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34C

genes like me logo Genes that share expression patterns with MIR34C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34C Gene

Orthologs for MIR34C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34C Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-34c 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34c 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-34c 30
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir34c 30
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34c 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34a 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-34c 30
  • 86 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 30
  • 32 (a)
OneToMany
Species where no ortholog for MIR34C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR34C Gene

ENSEMBL:
Gene Tree for MIR34C (if available)
TreeFam:
Gene Tree for MIR34C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR34C

Paralogs for MIR34C Gene

No data available for Paralogs for MIR34C Gene

Variants for MIR34C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR34C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR34C Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Additional Variant Information for MIR34C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34C
Leiden Open Variation Database (LOVD)
MIR34C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34C Gene

Disorders for MIR34C Gene

MalaCards: The human disease database

(56) MalaCards diseases for MIR34C Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
ovarian cancer
  • ovarian cancer, somatic
pancreatic cancer
  • pancreatic carcinoma
lung cancer
  • lung cancer, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34C

genes like me logo Genes that share disorders with MIR34C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34C Gene

Publications for MIR34C Gene

  1. Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. (PMID: 20198305) Cai KM … Zhao XJ (International journal of molecular medicine 2010) 3 72
  2. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PMID: 18519671) Toyota M … Tokino T (Cancer research 2008) 3 72
  3. Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis. (PMID: 32053576) Qin X … Zou H (Medical science monitor : international medical journal of experimental and clinical research 2020) 3
  4. Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells. (PMID: 32089626) Zheng H … Yu YL (World journal of gastroenterology 2020) 3
  5. PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma. (PMID: 32446383) Wu X … Chen B (Biochemical and biophysical research communications 2020) 3

Products for MIR34C Gene

Sources for MIR34C Gene