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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34C include Thyroid Gland Anaplastic Carcinoma and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and Apoptosis and survival Caspase cascade.
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis and survival Caspase cascade | ||
2 | MicroRNAs in cancer | ||
3 | Alzheimers Disease | ||
4 | Ectoderm Differentiation | ||
5 | Focal Adhesion |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IGI | 23047694 |
GO:0051898 | negative regulation of protein kinase B signaling | ISS | -- |
GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress | ISS | -- |
GO:1903671 | negative regulation of sprouting angiogenesis | ISS | -- |
GO:1905205 | positive regulation of connective tissue replacement | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00002C7B2B_9606 | miRNA | 23 | 6 |
RefSeq: NR_029840, LncBase: hsa-miR-34c-5p, miRBase: MIMAT0000686, MirGeneDB: Hsa-Mir-34-P2b_5p, TarBase: hsa-miR-34c-5p, |
URS00002C7C59_9606 | miRNA | 22 | 6 |
RefSeq: NR_029840, LncBase: hsa-miR-34c-3p, miRBase: MIMAT0004677, MirGeneDB: Hsa-Mir-34-P2b_3p, TarBase: hsa-miR-34c-3p, |
URS000075E7C8_9606 | precursor_RNA | 77 | 5 |
HGNC: 31637, RefSeq: NR_029840, Ensembl: ENST00000384831 (view in UCSC) , miRBase: MI0000743, |
URS00001DFE3F_9606 | precursor_RNA | 80 | 1 |
Rfam: RF00456, |
URS0000EFE91C_9606 | precursor_RNA | 56 | 1 |
MirGeneDB: Hsa-Mir-34-P2b, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | cfa-mir-34c 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-34c 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-34c 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir34c 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-34c 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-34a 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-34c 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-34 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
thyroid gland anaplastic carcinoma |
|
|
pancreatic cancer |
|
|
ovarian cancer |
|
|
lung cancer |
|
|
colorectal cancer |
|