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MIR34C Gene(RNA Gene)

MicroRNA 34c

GCID:
GC11P111538
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIR34C Gene

Subcategory (RNA class) for MIR34C Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR34C Gene

  • MicroRNA 34c 2 3 5
  • Hsa-Mir-34c 3
  • MiRNA34C 3
  • Mir-34c 3
  • MIRN34C 3

External Ids for MIR34C Gene

ORGUL Members for MIR34C Gene

Previous HGNC Symbols for MIR34C Gene

  • MIRN34C

Previous GeneCards Identifiers for MIR34C Gene

  • GC11P110906
  • GC11P110909
  • GC11P111384
  • GC11P111514
  • GC11P111517
  • GC11P111520
  • GC11P111523
  • GC11P111526
  • GC11P111529
  • GC11P111532
  • GC11P111535

Summaries for MIR34C Gene

Entrez Gene Summary for MIR34C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34C Gene

MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34C include Anaplastic Thyroid Cancer and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR34C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34C Gene

Genomics for MIR34C Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR34C Gene

Promoters and enhancers for MIR34C Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J111512 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.7 -0.3 -277 1.5 ZNF148 CTCF ZNF335 GLIS2 POLR2A ZBTB26 EZH2 BTG4 C11orf88 GC11P111544 GC11P111545 GC11P111546 GC11P111548 GC11P111549 GC11P111550 MIR34B MIR34C
GH11J111514 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +1.3 1291 0.9 CTCF ELF3 PKNOX1 RFX1 SIN3A BMI1 ZNF148 POLR2A PRDM10 C11orf88 BTG4 GC11P111544 GC11P111545 GC11P111546 GC11P111548 GC11P111549 GC11P111550 MIR34B MIR34C
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.8 +252.6 252577 3.3 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 POLR2B GLIS2 RUNX3 ZNF202 PPP2R1B ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 C11orf88 MIR34B MIR34C
GH11J111776 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 9.8 +264.4 264441 2.7 HDGF FOXA2 PKNOX1 SMAD1 ARID4B DMAP1 YY1 ARID2 ZNF143 ATF7 PPP2R1B ENSG00000254990 SIK2 LOC644277 POU2AF1 BTG4 C11orf88 MIR34B MIR34C ENSG00000254980
GH11J111375 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 -135.0 -134952 5.1 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ZNF143 POU2AF1 COLCA1 COLCA2 LOC644277 BTG4 C11orf88 MIR34B MIR34C RNU2-60P MIR4491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR34C Gene

Genomic Locations for MIR34C Gene
chr11:111,513,439-111,513,515
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr11:111,384,164-111,384,240
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR34C Gene

Genes around MIR34C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR34C Gene

Proteins for MIR34C Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR34C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34C Gene

Domains & Families for MIR34C Gene

Gene Families for MIR34C Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34C Gene

Function for MIR34C Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR34C Gene

Animal Model Products

miRNA for MIR34C Gene

miRTarBase miRNAs that target MIR34C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR34C Gene

Localization for MIR34C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34C Gene

Pathways & Interactions for MIR34C Gene

genes like me logo Genes that share pathways with MIR34C: view

Interacting Proteins for MIR34C Gene

Gene Ontology (GO) - Biological Process for MIR34C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 23047694
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34C: view

No data available for SIGNOR curated interactions for MIR34C Gene

Drugs & Compounds for MIR34C Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR34C Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR34C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34C Gene

No ASD Table

Relevant External Links for MIR34C Gene

GeneLoc Exon Structure for
MIR34C
ECgene alternative splicing isoforms for
MIR34C

Expression for MIR34C Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34C Gene

mRNA expression in normal human tissues for MIR34C Gene
mRNA expression by GTEx for MIR34C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34C Gene:

MIR34C
genes like me logo Genes that share expression patterns with MIR34C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34C Gene

Orthologs for MIR34C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia cfa-mir-34c 34
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-34c 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-34c 34
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir34c 34
  • 97 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-34c 34
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-34a 34
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-34c 34
  • 86 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea csa-mir-34 34
  • 32 (a)
 OneToMany
Species where no ortholog for MIR34C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR34C Gene

ENSEMBL:
Gene Tree for MIR34C (if available)
TreeFam:
Gene Tree for MIR34C (if available)

Paralogs for MIR34C Gene

No data available for Paralogs for MIR34C Gene

Variants for MIR34C Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR34C Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1004563559 -- 111,513,993(+) G/A/C downstream_transcript_variant
rs1004931609 -- 111,513,564(+) G/T downstream_transcript_variant
rs1006196846 -- 111,512,203(+) C/A upstream_transcript_variant
rs1006641351 -- 111,512,479(+) C/A upstream_transcript_variant
rs1007703616 -- 111,511,595(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR34C Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Additional Variant Information for MIR34C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34C Gene

Disorders for MIR34C Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR34C Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
anaplastic thyroid cancer
  • anaplastic thyroid carcinoma
pancreatic cancer
  • pancreatic carcinoma
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • lung cancer, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34C

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR34C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34C Gene

Publications for MIR34C Gene

  1. Low miR-34c expression is associated with poor outcome in de novo acute myeloid leukemia. (PMID: 27577964) Yang DQ … Qian J (International journal of laboratory hematology 2017) 3 58
  2. MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression. (PMID: 27704267) Xiao CZ … Guo RP (Journal of cancer research and clinical oncology 2017) 3 58
  3. Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer. (PMID: 27983526) Hashemi M … Taheri M (Cancer biomarkers : section A of Disease markers 2017) 3 58
  4. miR‑34c‑3p acts as a tumor suppressor gene in osteosarcoma by targeting MARCKS. (PMID: 28075441) Liu H … Zhao K (Molecular medicine reports 2017) 3 58
  5. A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma. (PMID: 28106538) Carvalho IN … Vargas FR (Cancer biomarkers : section A of Disease markers 2017) 3 58

Products for MIR34C Gene

Sources for MIR34C Gene

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