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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR34C Gene
RNA type for MIR34C Gene
miRNA
Aliases for MIR34C Gene
- MI0000743 (miRBase)
- MiRNA34C (NCBI Entrez Gene)
- MIRN34C (NCBI Entrez Gene)
- Mir-34c (NCBI Entrez Gene)
- RF00456 (Rfam)
- MIR34C (Ensembl)
External Ids for MIR34C Gene
- HGNC: 31637
- NCBI Entrez Gene: 407042
- Ensembl: ENSG00000207562
- OMIM®: 611375
- miRBase: hsa-mir-34c
Previous HGNC Symbols for MIR34C Gene
- MIRN34C
Previous GeneCards Identifiers for MIR34C Gene
- GC11P110906
- GC11P110909
- GC11P111384
- GC11P111514
- GC11P111517
- GC11P111559
- GC11P111565
- GC11P111571
- GC11P111579
- GC11P111520
- GC11P111523
- GC11P111526
- GC11P111529
- GC11P111532
- GC11P111535
- GC11P111538
- GC11P111548
- GC11P111582
Summaries for MIR34C Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR34C Gene
MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34C include Thyroid Gland Anaplastic Carcinoma and Ovarian Cancer. Among its related pathways are Apoptosis and survival Caspase cascade and MicroRNAs in cancer.
Rfam classification for MIR34C Gene
-
mir-34 microRNA precursor family
Additional gene information for MIR34C Gene
- Alliance of Genome Resources
- Search for MIR34C at DataMed
- Search for MIR34C at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34C Gene
Genomics for MIR34C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR34C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR34C on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR34C Gene
Latest Assembly
- chr11:111,513,438-111,513,517
- (GRCh38/hg38)
- Size:
- 80 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:111,384,164-111,384,240
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 77 bases
- Orientation:
- Plus strand
Genomic View for MIR34C Gene
Genes around MIR34C on UCSC Golden Path with GeneCards custom track
MIR34C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q23.1 by HGNC
- 11q23.1 by Entrez Gene
- 11q23.1 by Ensembl
MIR34C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR34C Gene
Proteins for MIR34C Gene
Post-translational modifications for MIR34C Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR34C Gene
Domains & Families for MIR34C Gene
Gene Families for MIR34C Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34C Gene
Function for MIR34C Gene
Phenotypes From GWAS Catalog for MIR34C Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR34C - Starting at $85 >
- * MIR34C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA for MIR34C Gene
- miRTarBase miRNAs that target MIR34C
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR34C - Starting at $45 >
- * MIR34C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR34C Gene
Localization for MIR34C Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34C Gene
Pathways & Interactions for MIR34C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and survival Caspase cascade | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Alzheimers Disease | ||
| 4 | Ectoderm Differentiation | ||
| 5 | Focal Adhesion | ||
Pathways by source for MIR34C Gene
1 KEGG pathway for MIR34C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IGI | 23047694 |
| GO:0051898 | negative regulation of protein kinase B signaling | ISS | -- |
| GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress | ISS | -- |
| GO:1903671 | negative regulation of sprouting angiogenesis | ISS | -- |
| GO:1905205 | positive regulation of connective tissue replacement | ISS | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR34C Gene
Transcripts for MIR34C Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34C Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00002C7B2B_9606 | miRNA | 23 | 6 |
RefSeq: NR_029840, LncBase: hsa-miR-34c-5p, miRBase: MIMAT0000686, MirGeneDB: Hsa-Mir-34-P2b_5p, TarBase: hsa-miR-34c-5p, |
| URS00002C7C59_9606 | miRNA | 22 | 6 |
RefSeq: NR_029840, LncBase: hsa-miR-34c-3p, miRBase: MIMAT0004677, MirGeneDB: Hsa-Mir-34-P2b_3p, TarBase: hsa-miR-34c-3p, |
| URS000075E7C8_9606 | precursor_RNA | 77 | 4 |
RefSeq: NR_029840, Ensembl: ENST00000384831 (view in UCSC) , miRBase: MI0000743, |
| URS00001DFE3F_9606 | pre_miRNA | 80 | 1 |
Rfam: RF00456, |
| URS0001BC40B6_9606 | pre_miRNA | 80 | 1 |
Rfam: RF00456, |
MIR34C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR34C Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR34C - Starting at $85 >
- * MIR34C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR34C - Starting at $45 >
- * MIR34C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR34C Gene
- GeneLoc Exon Structure for
- MIR34C
Expression for MIR34C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34C
Primer products for research
-
OriGene qPCR primer pairs for MIR34C
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34C Gene
Orthologs for MIR34C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | cfa-mir-34c 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-34c 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-34c 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir34c 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-34c 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-34a 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-34c 30 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-34 30 |
|
OneToMany |
- Species where no ortholog for MIR34C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for MIR34C Gene
- ENSEMBL:
- Gene Tree for MIR34C (if available)
- TreeFam:
- Gene Tree for MIR34C (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR34C
Paralogs for MIR34C Gene
No data available for Paralogs for MIR34C Gene
Variants for MIR34C Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR34C Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34C Gene
Disorders for MIR34C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thyroid gland anaplastic carcinoma |
|
|
| ovarian cancer |
|
|
| pancreatic cancer |
|
|
| lung cancer |
|
|
| colorectal cancer |
|
Search MIR34C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR34C
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34C Gene
Publications for MIR34C Gene
- Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. (PMID: 20198305) Cai KM … Zhao XJ (International journal of molecular medicine 2010) 3 72
- Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PMID: 18519671) Toyota M … Tokino T (Cancer research 2008) 3 72
- Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis. (PMID: 32053576) Qin X … Zou H (Medical science monitor : international medical journal of experimental and clinical research 2020) 3
- Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells. (PMID: 32089626) Zheng H … Yu YL (World journal of gastroenterology 2020) 3
- PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma. (PMID: 32446383) Wu X … Chen B (Biochemical and biophysical research communications 2020) 3
ExternalLinks
Products for MIR34C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR34C
- Origene Custom Protein Services for MIR34C
- Browse OriGene Inhibitory RNA Products For MIR34C
- OriGene qPCR primer pairs for MIR34C
- Browse CRISPR knockouts for MIR34C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR34C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR34C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR34C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR34C
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR34C
Sources for MIR34C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources