microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34B Gene

RNA type for MIR34B Gene


Aliases for MIR34B Gene

External Ids for MIR34B Gene

Previous HGNC Symbols for MIR34B Gene

  • MIRN34B

Previous GeneCards Identifiers for MIR34B Gene

  • GC11P110905
  • GC11P110908
  • GC11P111383
  • GC11P111513
  • GC11P111516
  • GC11P111550
  • GC11P111561
  • GC11P111570
  • GC11P111578
  • GC11P111519
  • GC11P111522
  • GC11P111525
  • GC11P111528
  • GC11P111531
  • GC11P111534
  • GC11P111537

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34B include Burkitt Lymphoma and Pancreatic Cancer. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR34B Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR34B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111514 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.7 +2.0 1963 0.6 SIN3A BMI1 RFX1 ELF3 PRDM10 CTCF PKNOX1 HOATZ BTG4 MIR34B MIR34C piR-39656 ENSG00000254980 LAYN
GH11J111512 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.7 +0.2 163 2.2 CTCF GLIS2 POLR2A EZH2 ZNF335 ZBTB26 BTG4 HOATZ MIR34B MIR34C piR-39656 PPP2R1B LAYN LOC728196 ENSG00000254980 POU2AF1
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 +253.1 253078 3.3 IKZF1 SSRP1 ZNF580 POLR2A NFIC ZIC2 YY1 SMAD5 SIN3A ZNF639 PPP2R1B HSALNG0087137 lnc-SIK2-3 ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 HOATZ
GH11J111375 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 9.2 -134.5 -134451 5.1 BCLAF1 ZNF207 POLR2A IRF4 EBF1 CBFB SMARCA5 MAX TAF1 BHLHE40 POU2AF1 lnc-BTG4-3 COLCA1 COLCA2 ENSG00000255093 BTG4 HOATZ MIR34B MIR34C HSALNG0087098
GH11J111776 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 9.8 +264.9 264942 2.7 ZNF654 CEBPA YY1 MXD4 CTCF REST ZNF592 TRIM22 KMT2B KDM6A PPP2R1B ENSG00000254990 HSALNG0087139 SIK2 ENSG00000255093 POU2AF1 BTG4 HOATZ MIR34B MIR34C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR34B Gene

Latest Assembly
84 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
84 bases
Plus strand

(GRCh37/hg19 by Ensembl)
84 bases
Plus strand

Genomic View for MIR34B Gene

Genes around MIR34B on UCSC Golden Path with GeneCards custom track
MIR34B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains & Families for MIR34B Gene

Gene Families for MIR34B Gene

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

Phenotypes From GWAS Catalog for MIR34B Gene

Gene Ontology (GO) - Molecular Function for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing HDA 18320040
genes like me logo Genes that share ontologies with MIR34B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR34B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways & Interactions for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA HDA,IEA --
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR34B Gene

Drugs & Compounds for MIR34B Gene

No Compound Related Data Available

Transcripts for MIR34B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000699DB3_9606 pre_miRNA 84 5

RefSeq: NR_029839,

Ensembl: ENST00000385076 (view in UCSC) ,

miRBase: MI0000742,

Rfam: RF00456,

ENA: LM608669.1:1..84:precursor_RNA,

URS0000432971_9606 miRNA 23 5

RefSeq: NR_029839,

LncBase: hsa-miR-34b-5p,

miRBase: MIMAT0000685,

TarBase: hsa-miR-34b-5p,

ENA: LM379205.1:1..23:ncRNA, LM608669.1:13..35:ncRNA,

URS000027352D_9606 miRNA 22 5

RefSeq: NR_029839,

LncBase: hsa-miR-34b-3p,

miRBase: MIMAT0004676,

TarBase: hsa-miR-34b-3p,

ENA: HB859630.1:1..22:misc_RNA, LM380340.1:1..22:ncRNA, LM608669.1:50..71:ncRNA,

URS0001BC34DF_9606 pre_miRNA 84 1

Rfam: RF00456,

URS0000EFDD2F_9606 pre_miRNA 60 1

MirGeneDB: Hsa-Mir-34-P2a,

MIR34B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR34B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for

Expression for MIR34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34B

genes like me logo Genes that share expression patterns with MIR34B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-34b 30
  • 100 (a)
(Mus musculus)
Mammalia Mir34b 30
  • 94 (a)
(Canis familiaris)
Mammalia cfa-mir-34b 30
  • 94 (a)
(Bos Taurus)
Mammalia bta-mir-34b 30
  • 92 (a)
(Monodelphis domestica)
Mammalia mdo-mir-34b 30
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 30
  • 86 (a)
(Gallus gallus)
Aves gga-mir-34b 30
  • 82 (a)
(Anolis carolinensis)
Reptilia aca-mir-34c 30
  • 78 (a)
(Danio rerio)
Actinopterygii dre-mir-34b 30
  • 69 (a)
dre-mir-34c 30
  • 51 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 30
  • 36 (a)
Species where no ortholog for MIR34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

Gene Tree for MIR34B (if available)
Gene Tree for MIR34B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR34B

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR34B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Additional Variant Information for MIR34B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34B Gene

Disorders for MIR34B Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR34B Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
burkitt lymphoma
  • bl
pancreatic cancer
  • pancreatic carcinoma
leukemia, acute myeloid
  • aml
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34B

genes like me logo Genes that share disorders with MIR34B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34B Gene

Publications for MIR34B Gene

  1. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PMID: 18519671) Toyota M … Tokino T (Cancer research 2008) 3 72
  2. [Correlation of MiR-34a/b/c Expression with Treatment Response and Prognosis of Elderly Patients with Acute Myeloid Leukemia]. (PMID: 32319382) Li H … Qin J (Zhongguo shi yan xue ye xue za zhi 2020) 3
  3. The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children. (PMID: 32083300) Wang J … Ruan J (Bioscience reports 2020) 3
  4. [Correlation between microRNA-34b/c single nucleotide polymorphism rs4938723 and male infertility]. (PMID: 33377704) Wang F … Xu XF (Zhonghua nan ke xue = National journal of andrology 2020) 3
  5. Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma. (PMID: 31996191) Ren ZH … Cao W (BMC oral health 2020) 3

Products for MIR34B Gene

Sources for MIR34B Gene