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Aliases for MIR34B Gene

Subcategory (RNA class) for MIR34B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34B Gene

  • MicroRNA 34b 2 3 5
  • Hsa-Mir-34b 3
  • MiRNA34B 3
  • Mir-34b 3
  • MIRN34B 3

External Ids for MIR34B Gene

ORGUL Members for MIR34B Gene

Previous HGNC Symbols for MIR34B Gene

  • MIRN34B

Previous GeneCards Identifiers for MIR34B Gene

  • GC11P110905
  • GC11P110908
  • GC11P111383
  • GC11P111513
  • GC11P111516
  • GC11P111519
  • GC11P111522
  • GC11P111525
  • GC11P111528
  • GC11P111531

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

Additional gene information for MIR34B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

GeneHancer (GH) Regulatory Elements for MIR34B Gene

Promoters and enhancers for MIR34B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I111512 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.2 212 1.5 ZNF148 CTCF ZNF335 GLIS2 POLR2A ZBTB26 EZH2 BTG4 C11orf88 GC11P111537 GC11P111538 GC11P111539 GC11P111544 GC11P111545 GC11P111546 MIR34B MIR34C
GH11I111514 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.8 +1.8 1792 0.9 CTCF ELF3 PKNOX1 RFX1 SIN3A BMI1 ZNF148 POLR2A PRDM10 C11orf88 BTG4 GC11P111537 GC11P111538 GC11P111539 GC11P111544 GC11P111545 GC11P111546 MIR34B MIR34C
GH11I111764 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.8 +253.1 253078 3.3 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 POLR2B GLIS2 RUNX3 ZNF202 PPP2R1B ALG9 NKAPD1 SIK2 ENSG00000255334 PIH1D2 LAYN BTG4 C11orf88 MIR34B
GH11I111375 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 -134.5 -134451 5.1 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ZNF143 POU2AF1 COLCA1 COLCA2 LOC644277 C11orf88 BTG4 MIR34B MIR34C RNU2-60P MIR4491
GH11I111697 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +185.8 185824 2.6 ATF1 PKNOX1 ARNT NCOA2 CHAMP1 TCF12 SMARCA5 ZEB2 ZNF592 MBD2 PPP2R1B NKAPD1 BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR34B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR34B Gene

Genomic Locations for MIR34B Gene
chr11:111,512,938-111,513,021
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr11:111,383,663-111,383,746
(GRCh37/hg19)

Genomic View for MIR34B Gene

Genes around MIR34B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains & Families for MIR34B Gene

Gene Families for MIR34B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

Phenotypes From GWAS Catalog for MIR34B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways & Interactions for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

Interacting Proteins for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34B: view

No data available for SIGNOR curated interactions for MIR34B Gene

Drugs & Compounds for MIR34B Gene

No Compound Related Data Available

Transcripts for MIR34B Gene

mRNA/cDNA for MIR34B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for
MIR34B
ECgene alternative splicing isoforms for
MIR34B

Expression for MIR34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34B Gene:

MIR34B
genes like me logo Genes that share expression patterns with MIR34B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-34b 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34b 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-34b 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34b 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34b 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-34c 34
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-34b 34
  • 69 (a)
OneToMany
dre-mir-34c 34
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 34
  • 36 (a)
OneToMany
Species where no ortholog for MIR34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

ENSEMBL:
Gene Tree for MIR34B (if available)
TreeFam:
Gene Tree for MIR34B (if available)

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

Sequence variations from dbSNP and Humsavar for MIR34B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000378890 -- 111,511,264(+) T/C upstream_transcript_variant
rs1000746492 -- 111,510,949(+) G/C upstream_transcript_variant
rs1004837620 -- 111,510,962(+) T/C upstream_transcript_variant
rs1004930989 -- 111,511,426(+) C/A upstream_transcript_variant
rs1006196846 -- 111,512,203(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Additional Variant Information for MIR34B Gene

Human Gene Mutation Database (HGMD)
MIR34B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34B Gene

Disorders for MIR34B Gene

Additional Disease Information for MIR34B

No disorders were found for MIR34B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34B Gene

Publications for MIR34B Gene

  1. The Rs4938723 Polymorphism Reduces Expression of MicroRNA-34b and Increases the Risk of Recurrence after Endoscopic Dissection in Early Gastric Cancer. (PMID: 28977792) Yu K (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  2. The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma. (PMID: 28512015) Daugaard I … Hansen LL (Experimental and molecular pathology 2017) 3 58
  3. miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis. (PMID: 28363996) Jiang L … Hermeking H (Cancer research 2017) 3 58
  4. Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. (PMID: 28277300) Jiao C … Xu X (Journal of pediatric surgery 2017) 3 58
  5. A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma. (PMID: 28106538) Carvalho IN … Vargas FR (Cancer biomarkers : section A of Disease markers 2017) 3 58

Products for MIR34B Gene

Sources for MIR34B Gene

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