microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34B Gene

Subcategory (RNA class) for MIR34B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR34B Gene

  • MicroRNA 34b 2 3 5
  • Hsa-MiR-34b-3p 163 173
  • Hsa-MiR-34b-5p 163 173
  • Hsa-Mir-34b 2 3
  • MIR34B 2 5
  • Hsa-Mir-34-P2a 178
  • MIMAT0000685 50
  • MIMAT0004676 50
  • MI0000742 50
  • MiRNA34B 3
  • MIRN34B 3
  • Mir-34b 3
  • RF00456 168

External Ids for MIR34B Gene

Previous HGNC Symbols for MIR34B Gene

  • MIRN34B

Previous GeneCards Identifiers for MIR34B Gene

  • GC11P110905
  • GC11P110908
  • GC11P111383
  • GC11P111513
  • GC11P111516
  • GC11P111550
  • GC11P111561
  • GC11P111570
  • GC11P111578
  • GC11P111519
  • GC11P111522
  • GC11P111525
  • GC11P111528
  • GC11P111531
  • GC11P111534
  • GC11P111537

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34B include Burkitt Lymphoma and Pancreatic Cancer. Among its related pathways are Parkinsons Disease Pathway and DNA Damage Response.

Rfam classification for MIR34B Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR34B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111514 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 +1.9 1863 0.8 PRDM10 RFX1 RFX5 PKNOX1 CTCF BMI1 POLR2A SIN3A ELF3 ZNF148 HOATZ BTG4 MIR34B MIR34C piR-39656 ENSG00000254980 LAYN
GH11J111512 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 +0.0 24 1.9 CTCF EZH2 ZBTB26 POLR2A ZNF335 ZNF148 GLIS2 BTG4 HOATZ MIR34B MIR34C piR-39656 PPP2R1B LAYN LOC728196 POU2AF1
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 +253.1 253078 3.3 HNRNPL PRDM10 ZNF629 REST IKZF1 POLR2A ZNF692 BACH1 LARP7 PRDM1 PPP2R1B lnc-SIK2-3 ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 HOATZ MIR34B
GH11J111375 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 9.2 -134.5 -134451 5.1 POLR2A BACH1 LARP7 ZNF143 RELA SMAD5 TCF12 IKZF2 RCOR1 YY1 POU2AF1 lnc-BTG4-3 COLCA1 COLCA2 ENSG00000255093 MIR34B MIR34C BTG4 HOATZ MIR4491
GH11J111776 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 9.8 +264.7 264687 3.2 GATAD2A CTCF REST ZNF143 RBFOX2 PKNOX1 RXRB RAD21 SP1 TRIM22 PPP2R1B ENSG00000254990 SIK2 ENSG00000255093 POU2AF1 BTG4 HOATZ MIR34B MIR34C ENSG00000254980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR34B Gene

Genomic Locations for MIR34B Gene
chr11:111,512,938-111,513,021
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr11:111,383,663-111,383,746
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR34B Gene

Genes around MIR34B on UCSC Golden Path with GeneCards custom track
MIR34B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains & Families for MIR34B Gene

Gene Families for MIR34B Gene

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

Phenotypes From GWAS Catalog for MIR34B Gene

Gene Ontology (GO) - Molecular Function for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing HDA 18320040
genes like me logo Genes that share ontologies with MIR34B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR34B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways & Interactions for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA HDA,IEA --
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR34B Gene

Drugs & Compounds for MIR34B Gene

No Compound Related Data Available

Transcripts for MIR34B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000699DB3_9606 precursor_RNA 84 6

HGNC: 31636,

RefSeq: NR_029839,

Ensembl: ENST00000385076 (view in UCSC) ,

miRBase: MI0000742,

Rfam: RF00456,

ENA: LM608669.1:1..84:precursor_RNA,

URS0000432971_9606 miRNA 23 5

RefSeq: NR_029839,

LncBase: hsa-miR-34b-5p,

miRBase: MIMAT0000685,

TarBase: hsa-miR-34b-5p,

ENA: LM379205.1:1..23:ncRNA, LM608669.1:13..35:ncRNA,

URS000027352D_9606 miRNA 22 5

RefSeq: NR_029839,

LncBase: hsa-miR-34b-3p,

miRBase: MIMAT0004676,

TarBase: hsa-miR-34b-3p,

ENA: HB859630.1:1..22:misc_RNA, LM380340.1:1..22:ncRNA, LM608669.1:50..71:ncRNA,

URS0000EFDD2F_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-34-P2a,

URS000050F7FA_9606 miRNA 23 1

ENA: AY940857.1:1..23:ncRNA,

MIR34B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR34B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for
MIR34B

Expression for MIR34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34B

genes like me logo Genes that share expression patterns with MIR34B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34b 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir34b 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-34b 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-34b 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34b 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-34b 31
  • 82 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-34c 31
  • 78 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-34b 31
  • 69 (a)
OneToMany
dre-mir-34c 31
  • 51 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 31
  • 36 (a)
OneToMany
Species where no ortholog for MIR34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

ENSEMBL:
Gene Tree for MIR34B (if available)
TreeFam:
Gene Tree for MIR34B (if available)

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

Additional dbSNP identifiers (rs#s) for MIR34B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Additional Variant Information for MIR34B Gene

Human Gene Mutation Database (HGMD)
MIR34B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34B Gene

Disorders for MIR34B Gene

MalaCards: The human disease database

(15) MalaCards diseases for MIR34B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • bl
pancreatic cancer
  • pancreatic carcinoma
leukemia, acute myeloid
  • aml
lung cancer
  • adenocarcinoma of lung
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34B

genes like me logo Genes that share disorders with MIR34B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34B Gene

Publications for MIR34B Gene

  1. [Correlation of MiR-34a/b/c Expression with Treatment Response and Prognosis of Elderly Patients with Acute Myeloid Leukemia]. (PMID: 32319382) Li H … Qin J (Zhongguo shi yan xue ye xue za zhi 2020) 3
  2. Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma. (PMID: 31996191) Ren ZH … Cao W (BMC oral health 2020) 3
  3. [Clinical Application of Plasma miR-34b-3p and miR-302a-5p in the Diagnosis of Non-small Cell Lung Cancer]. (PMID: 31014439) Song Z … Liu Y (Zhongguo fei ai za zhi = Chinese journal of lung cancer 2019) 3
  4. Role of miR‑34 in gastric cancer: From bench to bedside (Review). (PMID: 31432176) Xiong S … Chen H (Oncology reports 2019) 3
  5. Aberration methylation of miR-34b was involved in regulating vascular calcification by targeting Notch1. (PMID: 31129659) Lin X … Yuan LQ (Aging 2019) 3

Products for MIR34B Gene

Sources for MIR34B Gene