microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34A Gene

RNA type for MIR34A Gene

miRNA

Aliases for MIR34A Gene

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Retinoblastoma and Glioma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR34A Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR34A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR34A Gene

Latest Assembly
chr1:9,148,287-9,182,105
(GRCh38/hg38)
Size:
33,819 bases
Orientation:
Minus strand

Previous Assembly
chr1:9,211,727-9,211,836
(GRCh37/hg19 by Entrez Gene)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track
MIR34A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Phenotypes From GWAS Catalog for MIR34A Gene

Gene Ontology (GO) - Molecular Function for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 24637697
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23426265
genes like me logo Genes that share ontologies with MIR34A: view

Animal Models for research

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR34A gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR34A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR34A Gene

Pathways & Interactions for MIR34A Gene

PathCards logo

SuperPathways for MIR34A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 30111844
GO:0010628 positive regulation of gene expression IDA 27302634
GO:0010629 negative regulation of gene expression IMP 26330104
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA 23426265
GO:0010884 positive regulation of lipid storage IMP 26330104
genes like me logo Genes that share ontologies with MIR34A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

No Compound Related Data Available

Transcripts for MIR34A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34A Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000030BD69_9606 miRNA 22 6

RefSeq: NR_029610,

LncBase: hsa-miR-34a-5p,

miRBase: MIMAT0000255,

MirGeneDB: Hsa-Mir-34-P1_5p,

TarBase: hsa-miR-34a-5p,

ENA: LM378896.1:1..22:ncRNA, LM608342.1:22..43:ncRNA,

URS00000EED18_9606 miRNA 22 5

RefSeq: NR_029610,

LncBase: hsa-miR-34a-3p,

miRBase: MIMAT0004557,

TarBase: hsa-miR-34a-3p,

ENA: LM380236.1:1..22:ncRNA, LM608342.1:64..85:ncRNA,

URS000033F823_9606 pre_miRNA 110 4

RefSeq: NR_029610,

Ensembl: ENST00000385130 (view in UCSC) ,

miRBase: MI0000268,

ENA: EF609116.1:391..500:misc_RNA, LM608342.1:1..110:precursor_RNA,

URS00001478AF_9606 precursor_RNA 3648 1

ENA: EF570048.1:1..3648:precursor_RNA, EF570049.1:35..33853:precursor_RNA,

URS000064F123_9606 pre_miRNA 90 1

Rfam: RF00456,

MIR34A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR34A Gene

3 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325

Evidence on tissue expression from TISSUES for MIR34A Gene

  • Blood(2.4)
  • Liver(2.4)
  • Nervous system(2.3)
  • Intestine(2.3)
  • Heart(2.2)
  • Muscle(2.1)
  • Skin(2.1)
  • Kidney(2.1)
  • Lymph node(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with MIR34A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR34A

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR34A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Additional Variant Information for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A
Leiden Open Variation Database (LOVD)
MIR34A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

MalaCards: The human disease database

(102) MalaCards diseases for MIR34A Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34A

genes like me logo Genes that share disorders with MIR34A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia. (PMID: 20089965) Asslaber D … Greil R (Blood 2010) 3 72
  2. Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells. (PMID: 19443717) Dalgard CL … O'Brien JM (Investigative ophthalmology & visual science 2009) 3 72
  3. 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. (PMID: 18818704) Dijkstra MK … Jongen-Lavrencic M (Leukemia 2009) 3 72
  4. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M … Lowenstein CJ (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22
  5. Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. (PMID: 18834855) Fujita Y … Ito M (Biochemical and biophysical research communications 2008) 3 72

Products for MIR34A Gene

Sources for MIR34A Gene