microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-MiR-34a-5p 168 179
  • Hsa-MiR-34a-3p 168 179
  • MIMAT0004557 53
  • MIMAT0000255 53
  • Hsa-Mir-34a 3
  • MI0000268 53
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • RF00456 174
  • Mir-34 3
  • MIR34A 2

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Melanoma and Retinoblastoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR34A Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

GeneHancer (GH) Regulatory Elements for MIR34A Gene

Promoters and enhancers for MIR34A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009179 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 750.6 +0.2 204 4.6 ZNF24 CTCF RBPJ POLR2A NR2F6 ATF1 CREB1 MIXL1 ZNF362 RAD21 MIR34A LNCTAM34A GPR157 SLC2A5 CTNNBIP1 MIR34AHG
GH01J009237 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -59.7 -59722 8.2 FOXA1 RBPJ NR2F1 NR2F6 MYC HLF RAD21 MAX ZNF652 ZNF148 H6PD HSALNG0000688 GPR157 MIR34A RF00017-039
GH01J009434 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -257.7 -257740 11.2 SIN3A ZBTB6 FOXA1 RBPJ USF2 NR2F1 NR2F6 ATF1 CREB1 MIXL1 LINC02606 GPR157 MIR34A SPSB1 RNA5SP40
GH01J009210 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -29.2 -29174 1.8 NR2F1 NR2F6 CREB1 ZNF652 CEBPG CEBPA GATAD2A RXRB ZBTB26 FOS H6PD MIR34A GPR157 LNCTAM34A MIR34AHG piR-61945-002
GH01J009369 Enhancer 1.3 VISTA ENCODE CraniofacialAtlas dbSUPER 10.3 -191.5 -191518 8.1 ZBTB20 SCRT2 ZNF184 RFX1 ZBTB26 NR2F2 ZFHX2 WT1 NRF1 ZNF507 MIR34A RBP7 lnc-GPR157-6 piR-43105-005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR34A Gene

Genomic Locations for MIR34A Gene
chr1:9,148,287-9,182,105
(GRCh38/hg38)
Size:
33,819 bases
Orientation:
Minus strand
chr1:9,211,727-9,211,836
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Phenotypes From GWAS Catalog for MIR34A Gene

Gene Ontology (GO) - Molecular Function for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23426265
genes like me logo Genes that share ontologies with MIR34A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

Gene Ontology (GO) - Cellular Components for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR34A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR34A Gene

Pathways & Interactions for MIR34A Gene

PathCards logo

SuperPathways for MIR34A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 30111844
GO:0010628 positive regulation of gene expression IDA 27302634
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA 23426265
GO:0010942 positive regulation of cell death IMP 22651868
GO:0016525 negative regulation of angiogenesis IDA 20424141
genes like me logo Genes that share ontologies with MIR34A: view

No data available for SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

No Compound Related Data Available

Transcripts for MIR34A Gene

mRNA/cDNA for MIR34A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(7) RNACentral transcripts :
(2) LncBase transcripts :
(13) ENA transcripts :
(2) TarBase transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1002048210 -- 9,151,863(-) G/A upstream_transcript_variant
rs1004891985 -- 9,153,022(-) A/G upstream_transcript_variant
rs1005463528 -- 9,153,336(-) G/A upstream_transcript_variant
rs1005585465 -- 9,152,710(-) C/T upstream_transcript_variant
rs1006188293 -- 9,151,992(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Additional Variant Information for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

MalaCards: The human disease database

(29) MalaCards diseases for MIR34A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
retinoblastoma
  • rb1
glioma
leukemia, chronic lymphocytic
  • cll
neuroblastoma 1
  • neuroblastoma, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34A

genes like me logo Genes that share disorders with MIR34A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M … Lowenstein CJ (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23 56
  2. miR-34a inhibits progression of neuroblastoma by targeting autophagy-related gene 5. (PMID: 30716314) Cheng X … Zhang Q (European journal of pharmacology 2019) 3 56
  3. Knockdown of MALAT1 inhibits osteosarcoma progression via regulating the miR‑34a/cyclin D1 axis. (PMID: 30365098) Duan G … Zhang Y (International journal of oncology 2019) 3 56
  4. Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis. (PMID: 30387807) Liu Y … Zhao Q (International journal of molecular medicine 2019) 3 56
  5. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. (PMID: 29946193) Anastasiadou E … Slack FJ (Leukemia 2019) 3 56

Products for MIR34A Gene

Sources for MIR34A Gene