microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-MiR-34a-5p 163 173
  • Hsa-MiR-34a-3p 163 173
  • Hsa-Mir-34a 2 3
  • MIR34A 2 5
  • Hsa-Mir-34-P1 178
  • MIMAT0004557 50
  • MIMAT0000255 50
  • MI0000268 50
  • MiRNA34A 3
  • MIRN34A 3
  • Mir-34a 3
  • RF00456 168
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Melanoma and Retinoblastoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR34A Gene

  • mir-34 microRNA precursor family

Additional gene information for MIR34A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR34A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009179 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.2 204 4.6 HNRNPL GATAD2A CTCF PRDM10 ZNF629 POLR2A BACH1 LARP7 PRDM1 ZNF143 LNCTAM34A MIR34A MIR34AHG GPR157 SLC2A5 CTNNBIP1 H6PD
GH01J009434 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -257.7 -257740 11.2 HNRNPL GATAD2A ATF7 PRDM10 TFE3 SOX13 NFKBIZ RCOR2 JUND FOXA1 LINC02606 GPR157 MIR34A SPSB1 RNA5SP40 SLC25A33
GH01J009237 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -59.7 -59722 8.2 GATAD2A PRDM10 REST SOX13 RCOR2 PKNOX1 RXRB IRF2 IKZF2 SP1 H6PD HSALNG0000688 GPR157 MIR34A RF00017-039 MN308900 SPSB1
GH01J009210 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -29.2 -29174 1.8 GATAD2A JUND RXRB CEBPA CEBPB ZBTB26 NR2C2 FOS ZBTB25 TFDP1 H6PD MIR34A GPR157 LNCTAM34A MIR34AHG piR-61945-002
GH01J009369 Enhancer 1.3 VISTA ENCODE CraniofacialAtlas dbSUPER 10.3 -191.5 -191518 8.1 ZNF341 SCRT2 ZBTB44 ZBTB20 ZNF184 RFX1 ZBTB26 NR3C1 NR2F2 WT1 MIR34A RBP7 lnc-GPR157-6 piR-43105-005 SPSB1 SLC25A33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR34A Gene

Genomic Locations for MIR34A Gene
chr1:9,148,287-9,182,105
(GRCh38/hg38)
Size:
33,819 bases
Orientation:
Minus strand
chr1:9,211,727-9,211,836
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track
MIR34A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Phenotypes From GWAS Catalog for MIR34A Gene

Gene Ontology (GO) - Molecular Function for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23426265
genes like me logo Genes that share ontologies with MIR34A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR34A gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR34A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR34A Gene

Pathways & Interactions for MIR34A Gene

PathCards logo

SuperPathways for MIR34A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 30111844
GO:0010628 positive regulation of gene expression IDA 27302634
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA 23426265
GO:0010942 positive regulation of cell death IMP 22651868
GO:0016525 negative regulation of angiogenesis IDA 20424141
genes like me logo Genes that share ontologies with MIR34A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

No Compound Related Data Available

Transcripts for MIR34A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR34A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000030BD69_9606 miRNA 22 6

RefSeq: NR_029610,

LncBase: hsa-miR-34a-5p,

miRBase: MIMAT0000255,

MirGeneDB: Hsa-Mir-34-P1_5p,

TarBase: hsa-miR-34a-5p,

ENA: LM378896.1:1..22:ncRNA, LM608342.1:22..43:ncRNA,

URS000033F823_9606 precursor_RNA 110 5

HGNC: 31635,

RefSeq: NR_029610,

Ensembl: ENST00000385130 (view in UCSC) ,

miRBase: MI0000268,

ENA: EF609116.1:391..500:misc_RNA, LM608342.1:1..110:precursor_RNA,

URS00000EED18_9606 miRNA 22 5

RefSeq: NR_029610,

LncBase: hsa-miR-34a-3p,

miRBase: MIMAT0004557,

TarBase: hsa-miR-34a-3p,

ENA: LM380236.1:1..22:ncRNA, LM608342.1:64..85:ncRNA,

URS00001478AF_9606 precursor_RNA 3648 1

ENA: EF570048.1:1..3648:precursor_RNA, EF570049.1:35..33853:precursor_RNA,

URS000064F123_9606 precursor_RNA 90 1

Rfam: RF00456,

MIR34A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR34A Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325

Evidence on tissue expression from TISSUES for MIR34A Gene

  • Blood(2.7)
  • Liver(2.7)
  • Nervous system(2.5)
  • Intestine(2.5)
  • Heart(2.5)
  • Muscle(2.4)
  • Skin(2.4)
  • Kidney(2.4)
  • Lymph node(2.3)
  • Pancreas(2.3)
  • Bone marrow(2.2)
  • Lung(2.2)
  • Urine(2)
  • Bone(2)
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Additional dbSNP identifiers (rs#s) for MIR34A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Additional Variant Information for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

MalaCards: The human disease database

(92) MalaCards diseases for MIR34A Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34A

genes like me logo Genes that share disorders with MIR34A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M … Lowenstein CJ (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23
  2. MiR-34a-5p/PD-L1 axis regulates cisplatin chemoresistance of ovarian cancer cells. (PMID: 31777260) Zuo Y … Yang XS (Neoplasma 2020) 3
  3. LncRNA ANRIL promotes cell proliferation, migration and invasion during acute myeloid leukemia pathogenesis via negatively regulating miR-34a. (PMID: 31830533) Wang CH … Chen FP (The international journal of biochemistry & cell biology 2020) 3
  4. Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia. (PMID: 31923418) Cao HX … Jiang ZX (Life sciences 2020) 3
  5. RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression. (PMID: 31760527) Lin QY … Yin HL (Biotechnology letters 2020) 3

Products for MIR34A Gene

Sources for MIR34A Gene