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MIR34A Gene(RNA Gene)

MicroRNA 34a

GCID:
GC01M009151
GIFtS:
24
Genes Participants
UDN Logo

Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

19.2

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • Mir-34 3

External Ids for MIR34A Gene

ORGUL Members for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Melanoma and Retinoblastoma. Among its related pathways are MicroRNAs in cancer and mir34a and TGIF2 in osteoclastogenesis.

fRNAdb sequence ontologies for MIR34A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR34A

Additional gene information for MIR34A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR34A Gene

Promoters and enhancers for MIR34A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J009149 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 +0.9 899 2.8 ATF1 BACH1 CEBPG ZFHX2 CTBP1 SCRT2 TRIM24 ATF7 CREM EGR2 MIR34A SLC2A5 GPR157 MIR34AHG
GH01J009237 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -90.1 -90050 8.2 PKNOX1 FOXA2 ZFP64 ARID4B ZNF48 YY1 RUNX3 PAF1 RXRA SP5 H6PD GPR157 MIR34A PIR53045
GH01J009434 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -287.9 -287906 10.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 RNA5SP40 LOC100506022 GPR157 MIR34A SPSB1
GH01J009369 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 10.3 -221.8 -221846 8.1 ZFP64 ZMYM3 EBF1 ZNF507 ZFHX2 SCRT2 ZBTB20 RFX1 NRF1 CBFA2T3 MIR34A RBP7 ENSG00000284652 SPSB1
GH01J009231 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -80.1 -80059 1.3 RELA ZNF335 ZNF316 SCRT2 ZSCAN5C IKZF1 IKZF2 RUNX3 EMSY PRDM1 H6PD MIR34A GPR157 GC01M009234 GC01P009203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR34A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR34A Gene

Genomic Locations for MIR34A Gene
chr1:9,151,668-9,151,777
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:9,211,727-9,211,836
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR34A Gene

ORGUL Member Location for MIR34A Gene

ORGUL Member Location for MIR34A gene

Proteins for MIR34A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR34A Gene

Gene Ontology (GO) - Molecular Function for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23426265
genes like me logo Genes that share ontologies with MIR34A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways & Interactions for MIR34A Gene

genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 BioSystems pathway for MIR34A Gene
1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA 23426265
GO:0010942 positive regulation of cell death IMP 22651868
GO:0016525 negative regulation of angiogenesis IDA 20424141
GO:0030336 negative regulation of cell migration IMP 22651868
GO:0035195 gene silencing by miRNA IGI 23047694
genes like me logo Genes that share ontologies with MIR34A: view

No data available for SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR34A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR34A Gene

  • FR109864
  • FR136403

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34A Gene

mRNA expression in normal human tissues for MIR34A Gene
mRNA expression by GTEx for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1002048210 -- 9,151,863(-) G/A upstream_transcript_variant
rs1004891985 -- 9,153,022(-) A/G upstream_transcript_variant
rs1005463528 -- 9,153,336(-) G/A upstream_transcript_variant
rs1005585465 -- 9,152,710(-) C/T upstream_transcript_variant
rs1006188293 -- 9,151,992(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Additional Variant Information for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

MalaCards: The human disease database

(29) MalaCards diseases for MIR34A Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
retinoblastoma
  • rb1
glioma
leukemia, chronic lymphocytic
  • cll
neuroblastoma
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR34A

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR34A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M … Lowenstein CJ (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22 58
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
  3. High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells. (PMID: 29371016) Xue M … Xue YM (Biochemical and biophysical research communications 2018) 3 58
  4. Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer. (PMID: 29295989) Gibori H … Satchi-Fainaro R (Nature communications 2018) 3 58
  5. MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1. (PMID: 29054762) Zhou Y … Wang HB (Gene 2018) 3 58

Products for MIR34A Gene

Sources for MIR34A Gene

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