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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Melanoma and Retinoblastoma. Among its related pathways are MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23426265 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
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1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006974 | cellular response to DNA damage stimulus | IDA | 30111844 |
GO:0010628 | positive regulation of gene expression | IDA | 27302634 |
GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | IDA | 23426265 |
GO:0010942 | positive regulation of cell death | IMP | 22651868 |
GO:0016525 | negative regulation of angiogenesis | IDA | 20424141 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000030BD69_9606 | miRNA | 22 | 6 |
RefSeq: NR_029610, LncBase: hsa-miR-34a-5p, miRBase: MIMAT0000255, MirGeneDB: Hsa-Mir-34-P1_5p, TarBase: hsa-miR-34a-5p, |
URS000033F823_9606 | precursor_RNA | 110 | 5 |
HGNC: 31635, RefSeq: NR_029610, Ensembl: ENST00000385130 (view in UCSC) , miRBase: MI0000268, ENA: EF609116.1:391..500:misc_RNA, LM608342.1:1..110:precursor_RNA, |
URS00000EED18_9606 | miRNA | 22 | 5 |
RefSeq: NR_029610, LncBase: hsa-miR-34a-3p, miRBase: MIMAT0004557, TarBase: hsa-miR-34a-3p, |
URS00001478AF_9606 | precursor_RNA | 3648 | 1 |
ENA: EF570048.1:1..3648:precursor_RNA, EF570049.1:35..33853:precursor_RNA, |
URS000064F123_9606 | precursor_RNA | 90 | 1 |
Rfam: RF00456, |
Disorder | Aliases | PubMed IDs |
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melanoma |
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retinoblastoma |
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glioma |
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leukemia, chronic lymphocytic |
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neuroblastoma |
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