Subcategory (RNA class) for MIR34A Gene
Quality Score for this RNA gene is
External Ids for MIR34A Gene
ORGUL Members for MIR34A Gene
Previous HGNC Symbols for MIR34A Gene
Previous GeneCards Identifiers for MIR34A Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
GeneCards Summary for MIR34A Gene
MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include Age-Related Hearing Loss. Among its related pathways are mir34a and TGIF2 in osteoclastogenesis and MicroRNAs in cancer.
fRNAdb sequence ontologies for MIR34A Gene - the ORGUL cluster for this gene includes several descriptions:
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.