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Aliases for MIR346 Gene

Subcategory (RNA class) for MIR346 Gene


Quality Score for this RNA gene is


Aliases for MIR346 Gene

  • MicroRNA 346 2 3 5
  • Hsa-Mir-346 3
  • MiRNA346 3
  • MiR-346 3
  • MIRN346 3

External Ids for MIR346 Gene

Previous HGNC Symbols for MIR346 Gene

  • MIRN346

Previous GeneCards Identifiers for MIR346 Gene

  • GC10M088016

Summaries for MIR346 Gene

Entrez Gene Summary for MIR346 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR346 Gene

MIR346 (MicroRNA 346) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR346 include Thyroid Cancer, Nonmedullary, 2 and Primary Biliary Cirrhosis.

fRNAdb sequence ontologies for MIR346 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR346

Additional gene information for MIR346 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR346 Gene

Genomics for MIR346 Gene

GeneHancer (GH) Regulatory Elements for MIR346 Gene

Promoters and enhancers for MIR346 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J086376 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.6 -112.4 -112435 0.9 RB1 SIN3A KLF14 KLF5 BRCA1 ZNF48 RAD21 ZNF335 SCRT2 ZNF207 MIR346 GC10M086380 GRID1
GH10J086585 Enhancer 1.1 Ensembl ENCODE 9.3 -320.7 -320709 0.7 ELF3 SREBF2 ARID4B IRF4 RAD21 GLIS2 ZNF143 KLF7 THAP11 MIXL1 ENSG00000227896 WAPL RNU6-780P MIR346 OPN4 GC10P086567 RPL7AP8
GH10J086355 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.8 -90.9 -90917 0.6 POLR2A MAX EBF1 MYC SPI1 MIR346 GRID1
GH10J086225 Enhancer 0.8 Ensembl ENCODE 11.7 +39.5 39488 0.6 KLF17 MAFG BACH1 ZNF316 ZFP91 NFE2 MAFK EMSY MIR346 GC10P086201 GRID1
GH10J086309 Enhancer 0.7 dbSUPER 11.5 -50.4 -50416 11.3 PKNOX1 KLF17 ZIC2 ZFHX2 GATA3 ZNF316 ZNF366 PRDM10 RCOR1 NFE2 ENSG00000227896 ADIRF-AS1 GRID1 MIR346 WAPL MMRN2 LDB3 OPN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR346 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR346 Gene

Genomic Locations for MIR346 Gene
95 bases
Minus strand
95 bases
Minus strand

Genomic View for MIR346 Gene

Genes around MIR346 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR346 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR346 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR346 Gene

ORGUL Member Location for MIR346 Gene

ORGUL Member Location for MIR346 gene

Proteins for MIR346 Gene

Post-translational modifications for MIR346 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR346 Gene

Domains & Families for MIR346 Gene

Gene Families for MIR346 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR346: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR346 Gene

Function for MIR346 Gene

Phenotypes From GWAS Catalog for MIR346 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR346 Gene

Localization for MIR346 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR346 Gene

Pathways & Interactions for MIR346 Gene

SuperPathways for MIR346 Gene

No Data Available

Interacting Proteins for MIR346 Gene

Gene Ontology (GO) - Biological Process for MIR346 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR346 Gene

Drugs & Compounds for MIR346 Gene

No Compound Related Data Available

Transcripts for MIR346 Gene

fRNAdb Secondary structures for MIR346 Gene

  • hsa-mir-346_MI0000826_Homo_sapiens_miR-346_stem-loop_hairpin

mRNA/cDNA for MIR346 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR346 Gene

No ASD Table

Relevant External Links for MIR346 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR346 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR346 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR346 Gene:

genes like me logo Genes that share expression patterns with MIR346: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR346 Gene

Orthologs for MIR346 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR346 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-346 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-346 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-346 34
  • 97 (a)
(Mus musculus)
Mammalia Mir346 34
  • 90 (a)
Species where no ortholog for MIR346 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR346 Gene

Gene Tree for MIR346 (if available)
Gene Tree for MIR346 (if available)

Paralogs for MIR346 Gene

No data available for Paralogs for MIR346 Gene

Variants for MIR346 Gene

Sequence variations from dbSNP and Humsavar for MIR346 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000472609 -- 86,264,361(-) C/T downstream_transcript_variant
rs1002141852 -- 86,265,947(-) G/A upstream_transcript_variant
rs1004975447 -- 86,266,740(-) C/T upstream_transcript_variant
rs1005030240 -- 86,266,543(-) A/G upstream_transcript_variant
rs1008955004 -- 86,266,668(-) ATA/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR346 Gene

Variant ID Type Subtype PubMed ID
esv3579031 CNV loss 25503493
nsv1051761 CNV loss 25217958
nsv1052427 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv520914 CNV loss 19592680
nsv551773 CNV loss 21841781
nsv831936 CNV loss 17160897
nsv831938 CNV gain 17160897

Additional Variant Information for MIR346 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR346 Gene

Disorders for MIR346 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR346 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
thyroid cancer, nonmedullary, 2
  • nmtc2
primary biliary cirrhosis
  • biliary liver cirrhosis
  • sczd
systemic lupus erythematosus
  • sle
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR346

genes like me logo Genes that share disorders with MIR346: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR346 Gene

Publications for MIR346 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J … Ruvkun G (Proceedings of the National Academy of Sciences of the United States of America 2004) 1 3 58
  3. miR-346 functions as a pro-survival factor under ER stress by activating mitophagy. (PMID: 29107113) Guo J … Tang H (Cancer letters 2018) 3 58
  4. MiR-346 promotes the biological function of breast cancer cells by targeting SRCIN1 and reduces chemosensitivity to docetaxel. (PMID: 27913185) Yang F … Tang JH (Gene 2017) 3 58
  5. miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. (PMID: 27619846) Su MT … Kuo PL (BioFactors (Oxford, England) 2017) 3 58

Products for MIR346 Gene

Sources for MIR346 Gene

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