microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR346 Gene

Subcategory (RNA class) for MIR346 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR346 Gene

  • MI0000826 50
  • MiRNA346 3
  • MIRN346 3
  • MiR-346 3
  • RF00758 168

External Ids for MIR346 Gene

Previous HGNC Symbols for MIR346 Gene

  • MIRN346

Previous GeneCards Identifiers for MIR346 Gene

  • GC10M088016

Summaries for MIR346 Gene

Entrez Gene Summary for MIR346 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR346 Gene

MIR346 (MicroRNA 346) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR346 include Thyroid Cancer, Nonmedullary, 2 and Primary Biliary Cirrhosis.

Rfam classification for MIR346 Gene

Additional gene information for MIR346 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR346 Gene

Genomics for MIR346 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR346 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J086265 Enhancer 0.7 Ensembl dbSUPER 600.7 -0.8 -813 0.4 POLR2A RAD21 ZFHX2 RCOR1 RFX5 CHD2 MAX GATA2 KLF14 MIR346 RF01045-022 GRID1
GH10J086224 Enhancer 1 FANTOM5 Ensembl ENCODE 12 +36.6 36588 7.6 CREB1 ZNF776 SCRT2 EED EGR1 ZNF157 NFE2 ZNF316 YBX1 TCF12 MIR346 WAPL piR-55627-017 piR-46501-009 GRID1
GH10J086376 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 -112.6 -112613 0.8 CTCF KDM1A BACH1 LARP7 ZNF143 REST RAD21 RCOR1 TRIM22 IRF3 MIR346 lnc-GRID1-4 HSALNG0079392 GRID1 WAPL
GH10J086292 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.7 -28.4 -28413 2.4 CTCF TEAD4 KDM1A ZNF24 ZFHX2 ZNF223 RAD21 EGR2 SP1 ELF1 MIR346 GRID1 RF01045-022
GH10J086162 Enhancer 0.9 Ensembl ENCODE 10.4 +101.1 101062 2.8 CEBPG GATAD2A ZIC2 SP1 CEBPA CEBPB YY1 CREB1 ZBTB17 JUND MIR346 piR-46501-009 piR-55627-017 GRID1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR346 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR346 Gene

Genomic Locations for MIR346 Gene
chr10:86,264,687-86,264,788
(GRCh38/hg38)
Size:
102 bases
Orientation:
Minus strand
chr10:88,024,451-88,024,545
(GRCh37/hg19)
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR346 Gene

Genes around MIR346 on UCSC Golden Path with GeneCards custom track
MIR346 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR346 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR346 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR346 Gene

Proteins for MIR346 Gene

Post-translational modifications for MIR346 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR346 Gene

Domains & Families for MIR346 Gene

Gene Families for MIR346 Gene

HGNC:
genes like me logo Genes that share domains with MIR346: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR346 Gene

Function for MIR346 Gene

Phenotypes From GWAS Catalog for MIR346 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR346 Gene

Localization for MIR346 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR346 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR346 Gene

Pathways & Interactions for MIR346 Gene

PathCards logo

SuperPathways for MIR346 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR346 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR346: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR346 Gene

Drugs & Compounds for MIR346 Gene

No Compound Related Data Available

Transcripts for MIR346 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR346 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000134ADC_9606 miRNA 23 6

RefSeq: NR_029907,

LncBase: hsa-miR-346,

miRBase: MIMAT0000773,

MirGeneDB: Hsa-Mir-346_5p,

TarBase: hsa-miR-346,

ENA: LM379276.1:1..23:ncRNA, LM608742.1:20..42:ncRNA,

URS000075B886_9606 precursor_RNA 95 5

HGNC: 31780,

RefSeq: NR_029907,

Ensembl: ENST00000362234 (view in UCSC) ,

miRBase: MI0000826,

ENA: LM608742.1:1..95:precursor_RNA,

URS0000625EE2_9606 precursor_RNA 98 1

Rfam: RF00758,

URS0000EFC0CA_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-346,

URS00002FAF0F_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-346_3p,

MIR346 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR346 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR346 Gene

No ASD Table

Relevant External Links for MIR346 Gene

GeneLoc Exon Structure for
MIR346

Expression for MIR346 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR346 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR346

genes like me logo Genes that share expression patterns with MIR346: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR346 Gene

Orthologs for MIR346 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR346 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-346 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-346 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-346 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir346 31
  • 90 (a)
OneToOne
Species where no ortholog for MIR346 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR346 Gene

ENSEMBL:
Gene Tree for MIR346 (if available)
TreeFam:
Gene Tree for MIR346 (if available)

Paralogs for MIR346 Gene

No data available for Paralogs for MIR346 Gene

Variants for MIR346 Gene

Additional dbSNP identifiers (rs#s) for MIR346 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR346 Gene

Variant ID Type Subtype PubMed ID
esv3579031 CNV loss 25503493
nsv1051761 CNV loss 25217958
nsv1052427 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv520914 CNV loss 19592680
nsv551773 CNV loss 21841781
nsv831936 CNV loss 17160897
nsv831938 CNV gain 17160897

Additional Variant Information for MIR346 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR346

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR346 Gene

Disorders for MIR346 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR346 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR346

genes like me logo Genes that share disorders with MIR346: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR346 Gene

Publications for MIR346 Gene

  1. MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway. (PMID: 31953162) Pan S … Dong Y (Life sciences 2020) 3
  2. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease. (PMID: 30470799) Long JM … Lahiri DK (Molecular psychiatry 2019) 3
  3. LncRNA NBAT1 suppresses cell proliferation and migration via miR-346/GSK-3β axis in renal carcinoma. (PMID: 31298469) Xue S … Li Q (IUBMB life 2019) 3
  4. Hsa-miR-346 plays a role in the development of sepsis by downregulating SMAD3 expression and is negatively regulated by lncRNA MALAT1. (PMID: 31494280) Yang Q … Zhang J (Molecular and cellular probes 2019) 3
  5. miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression. (PMID: 29295726) Guo Z … Yu Z (Oncology research 2018) 3

Products for MIR346 Gene

Sources for MIR346 Gene