microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR345 Gene

Subcategory (RNA class) for MIR345 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR345 Gene

  • MicroRNA 345 2 3 5
  • Hsa-Mir-345 2 3 178
  • Hsa-MiR-345-5p 163 173
  • MIR345 2 5
  • MIMAT0000772 50
  • MIMAT0022698 50
  • MI0000825 50
  • MIRN345 3
  • Mir-345 3
  • RF01044 168

External Ids for MIR345 Gene

Previous HGNC Symbols for MIR345 Gene

  • MIRN345

Previous GeneCards Identifiers for MIR345 Gene

  • GC14P099845
  • GC14P100944
  • GC14P100993
  • GC14P101004
  • GC14P101012
  • GC14P101021
  • GC14P101032
  • GC14P101046
  • GC14P101076
  • GC14P101113
  • GC14P101162
  • GC14P101224

Summaries for MIR345 Gene

Entrez Gene Summary for MIR345 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR345 Gene

MIR345 (MicroRNA 345) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR345 include Oral Cancer and Mesothelioma, Malignant. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR345 Gene

Additional gene information for MIR345 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR345 Gene

Genomics for MIR345 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR345 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100304 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.3 -1275 4.6 CEBPG SP1 HNRNPL TEAD4 PRDM10 KDM1A ZNF692 RCOR2 BACH1 TARDBP SLC25A29 MIR345 lnc-WARS-1 lnc-WARS-2 CCNK YY1 MEG3 SLC25A47
GH14J100309 Enhancer 0.6 CraniofacialAtlas dbSUPER 600.7 +1.4 1405 0.4 SP1 NR2F2 RAD21 CTCF MIR345 SLC25A29 piR-52261-085 SLC25A47
GH14J100279 Enhancer 0.8 ENCODE dbSUPER 12.2 -28.8 -28770 0.9 HNRNPL FOXA1 SOX13 CTCF RUNX3 NFE2 PKNOX1 TEAD1 RBM22 POLR2A MIR6764 lnc-SLC25A47-5 lnc-SLC25A47-6 MIR345 SLC25A29 WARS1 WDR25 SLC25A47 MIR342 ENSG00000259052
GH14J100336 Enhancer 0.6 dbSUPER 12 +29.1 29134 1.4 DPF2 RELB CEBPB POLR2A ZNF592 ARNT JUNB BATF MTA2 BHLHE40 WARS1 MIR345 SLC25A29 WDR25 ENSG00000258666 piR-58720 SLC25A47
GH14J100278 Enhancer 0.5 UCNEbase dbSUPER 12.2 -29.7 -29683 0.3 MIR6764 lnc-SLC25A47-5 lnc-SLC25A47-6 MIR345 SLC25A29 WARS1 WDR25 SLC25A47 MIR342 YY1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR345 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR345 Gene

Genomic Locations for MIR345 Gene
chr14:100,307,859-100,307,956
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr14:100,774,196-100,774,293
(GRCh37/hg19)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR345 Gene

Genes around MIR345 on UCSC Golden Path with GeneCards custom track
MIR345 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR345 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR345 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR345 Gene

Proteins for MIR345 Gene

Post-translational modifications for MIR345 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR345 Gene

Domains & Families for MIR345 Gene

Gene Families for MIR345 Gene

HGNC:
genes like me logo Genes that share domains with MIR345: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR345 Gene

Function for MIR345 Gene

Gene Ontology (GO) - Molecular Function for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR345: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR345 Gene

Localization for MIR345 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR345 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR345: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR345 Gene

Pathways & Interactions for MIR345 Gene

PathCards logo

SuperPathways for MIR345 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR345: view

Pathways by source for MIR345 Gene

1 KEGG pathway for MIR345 Gene

Gene Ontology (GO) - Biological Process for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
genes like me logo Genes that share ontologies with MIR345: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR345 Gene

Drugs & Compounds for MIR345 Gene

No Compound Related Data Available

Transcripts for MIR345 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR345 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000005D4F5_9606 miRNA 22 6

RefSeq: NR_029906,

LncBase: hsa-miR-345-5p,

miRBase: MIMAT0000772,

MirGeneDB: Hsa-Mir-345_5p,

TarBase: hsa-miR-345-5p,

ENA: LM379275.1:1..22:ncRNA, LM608741.1:18..39:ncRNA,

URS000075E1CD_9606 precursor_RNA 98 5

HGNC: 31779,

RefSeq: NR_029906,

Ensembl: ENST00000362114 (view in UCSC) ,

miRBase: MI0000825,

ENA: LM608741.1:1..98:precursor_RNA,

URS0000384659_9606 miRNA 22 4

RefSeq: NR_029906,

miRBase: MIMAT0022698,

MirGeneDB: Hsa-Mir-345_3p,

ENA: LM383006.1:1..22:ncRNA, LM608741.1:54..75:ncRNA,

URS00006C0B51_9606 precursor_RNA 97 1

Rfam: RF01044,

URS0000EFD039_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-345,

MIR345 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR345 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR345 Gene

No ASD Table

Relevant External Links for MIR345 Gene

GeneLoc Exon Structure for
MIR345

Expression for MIR345 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR345 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR345

genes like me logo Genes that share expression patterns with MIR345: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR345 Gene

Orthologs for MIR345 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR345 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-345 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-345 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-345 31
  • 93 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mir345 31
  • 79 (a)
OneToOne
Species where no ortholog for MIR345 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR345 Gene

ENSEMBL:
Gene Tree for MIR345 (if available)
TreeFam:
Gene Tree for MIR345 (if available)

Paralogs for MIR345 Gene

No data available for Paralogs for MIR345 Gene

Variants for MIR345 Gene

Additional dbSNP identifiers (rs#s) for MIR345 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR345 Gene

Variant ID Type Subtype PubMed ID
esv3635502 CNV gain 21293372
nsv832875 CNV loss 17160897

Additional Variant Information for MIR345 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR345

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR345 Gene

Disorders for MIR345 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR345 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • lip and oral cavity carcinoma
mesothelioma, malignant
  • mesom
systemic lupus erythematosus
  • sle
pancreatic cancer
  • pancreatic carcinoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR345

genes like me logo Genes that share disorders with MIR345: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR345 Gene

Publications for MIR345 Gene

  1. MiR-345-3p attenuates apoptosis and inflammation caused by oxidized low-density lipoprotein by targeting TRAF6 via TAK1/p38/NF-kB signaling in endothelial cells. (PMID: 31825793) Wei Q … Qiu J (Life sciences 2020) 3
  2. MiR-345-5p functions as a tumor suppressor in pancreatic cancer by directly targeting CCL8. (PMID: 30841468) Mou T … Wang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. Functional roles and potential clinical application of miRNA-345-5p in prostate cancer. (PMID: 29748958) Tinay I … Jia L (The Prostate 2018) 3
  4. MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. (PMID: 29048674) Feng A … Li X (Oncology reports 2017) 3
  5. MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1. (PMID: 28677785) Zhang H … Bi H (Oncology reports 2017) 3

Products for MIR345 Gene

Sources for MIR345 Gene