microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR342 Gene

Subcategory (RNA class) for MIR342 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR342 Gene

  • MIMAT0004694 50
  • MIMAT0000753 50
  • MI0000805 50
  • MIRN342 3
  • RF00760 168

External Ids for MIR342 Gene

Previous HGNC Symbols for MIR342 Gene

  • MIRN342

Previous GeneCards Identifiers for MIR342 Gene

  • GC14P099647
  • GC14P100986
  • GC14P100991
  • GC14P101000
  • GC14P101013
  • GC14P101019
  • GC14P101030
  • GC14P101048
  • GC14P101074
  • GC14P101111
  • GC14P101160
  • GC14P101220

Summaries for MIR342 Gene

Entrez Gene Summary for MIR342 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR342 Gene

MIR342 (MicroRNA 342) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR342 include Sezary's Disease and Colorectal Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR342 Gene

Additional gene information for MIR342 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR342 Gene

Genomics for MIR342 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR342 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR342 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR342 Gene

Genomic Locations for MIR342 Gene
chr14:100,109,655-100,109,753
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr14:100,575,992-100,576,090
(GRCh37/hg19)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR342 Gene

Genes around MIR342 on UCSC Golden Path with GeneCards custom track
MIR342 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR342 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR342 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR342 Gene

Proteins for MIR342 Gene

Post-translational modifications for MIR342 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR342 Gene

Domains & Families for MIR342 Gene

Gene Families for MIR342 Gene

HGNC:
genes like me logo Genes that share domains with MIR342: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR342 Gene

Function for MIR342 Gene

Phenotypes From GWAS Catalog for MIR342 Gene

Gene Ontology (GO) - Molecular Function for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26857067
genes like me logo Genes that share ontologies with MIR342: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR342 Gene

Localization for MIR342 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR342 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR342: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR342 Gene

Pathways & Interactions for MIR342 Gene

PathCards logo

SuperPathways for MIR342 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR342: view

Pathways by source for MIR342 Gene

1 KEGG pathway for MIR342 Gene

Gene Ontology (GO) - Biological Process for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 26857067
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26857067
GO:0051898 negative regulation of protein kinase B signaling IDA 26857067
GO:0062000 positive regulation of cardiac endothelial to mesenchymal transition IDA 26857067
genes like me logo Genes that share ontologies with MIR342: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR342 Gene

Drugs & Compounds for MIR342 Gene

No Compound Related Data Available

Transcripts for MIR342 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR342 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000071B780_9606 precursor_RNA 99 6

HGNC: 31778,

RefSeq: NR_029888,

Ensembl: ENST00000362212 (view in UCSC) ,

miRBase: MI0000805,

Rfam: RF00760,

ENA: LM608723.1:1..99:precursor_RNA,

URS0000148B91_9606 miRNA 23 5

RefSeq: NR_029888,

LncBase: hsa-miR-342-3p,

miRBase: MIMAT0000753,

TarBase: hsa-miR-342-3p,

ENA: LM379258.1:1..23:ncRNA, LM608723.1:61..83:ncRNA,

URS00005A8080_9606 miRNA 21 5

RefSeq: NR_029888,

LncBase: hsa-miR-342-5p,

miRBase: MIMAT0004694,

TarBase: hsa-miR-342-5p,

ENA: LM380355.1:1..21:ncRNA, LM608723.1:19..39:ncRNA,

URS0000EFD26A_9606 precursor_RNA 68 1

MirGeneDB: Hsa-Mir-342,

URS0000D516DD_9606 miRNA 27 1

MirGeneDB: Hsa-Mir-342_5p,

MIR342 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR342 Gene

No ASD Table

Relevant External Links for MIR342 Gene

GeneLoc Exon Structure for
MIR342

No data available for mRNA/cDNA for MIR342 Gene

Expression for MIR342 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR342 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR342

Evidence on tissue expression from TISSUES for MIR342 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with MIR342: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR342 Gene

Orthologs for MIR342 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR342 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-342 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir342 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-342 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-342 31
  • 81 (a)
OneToOne
Species where no ortholog for MIR342 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR342 Gene

ENSEMBL:
Gene Tree for MIR342 (if available)
TreeFam:
Gene Tree for MIR342 (if available)

Paralogs for MIR342 Gene

No data available for Paralogs for MIR342 Gene

Variants for MIR342 Gene

Additional dbSNP identifiers (rs#s) for MIR342 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR342 Gene

Variant ID Type Subtype PubMed ID
nsv527130 CNV loss 19592680
nsv832874 CNV loss 17160897

Additional Variant Information for MIR342 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR342

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR342 Gene

Disorders for MIR342 Gene

MalaCards: The human disease database

(57) MalaCards diseases for MIR342 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
colorectal cancer
  • crc
prion disease
  • prion disease pathway
acute promyelocytic leukemia
  • apl
kidney cancer
  • renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR342

genes like me logo Genes that share disorders with MIR342: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR342 Gene

Publications for MIR342 Gene

  1. Inhibiting the expression of anti-apoptotic genes BCL2L1 and MCL1, and apoptosis induction in glioblastoma cells by microRNA-342. (PMID: 31751869) Ghaemi S … Jamshidi Adegani F (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  2. miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6. (PMID: 31746345) Jiang ZH … Ni CL (International journal of molecular medicine 2020) 3
  3. miR-342-5p inhibits expression of Bmp7 to regulate proliferation, differentiation and migration of osteoblasts. (PMID: 31398664) Li X … Liu C (Molecular immunology 2019) 3
  4. microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells. (PMID: 30678643) Cui Z … Zhao Y (BMC cancer 2019) 3
  5. miR‑342 inhibits glioma cell proliferation by targeting GPRC5A. (PMID: 31115523) Wang J … Tang X (Molecular medicine reports 2019) 3

Products for MIR342 Gene

Sources for MIR342 Gene