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Aliases for MIR342 Gene

Subcategory (RNA class) for MIR342 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR342 Gene

  • MicroRNA 342 2 3 5
  • Hsa-Mir-342 3
  • MIRN342 3

External Ids for MIR342 Gene

ORGUL Members for MIR342 Gene

Previous HGNC Symbols for MIR342 Gene

  • MIRN342

Previous GeneCards Identifiers for MIR342 Gene

  • GC14P099647
  • GC14P100986
  • GC14P100991
  • GC14P101000
  • GC14P101013
  • GC14P101019
  • GC14P101030
  • GC14P101048
  • GC14P101074
  • GC14P101111
  • GC14P101160
  • GC14P101220

Summaries for MIR342 Gene

Entrez Gene Summary for MIR342 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR342 Gene

MIR342 (MicroRNA 342) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR342 include Sezary's Disease and Colorectal Cancer. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR342 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR342 Gene

Genomics for MIR342 Gene

GeneHancer (GH) Regulatory Elements for MIR342 Gene

Promoters and enhancers for MIR342 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100062 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 -39.5 -39543 15.4 SP1 ZFX CBFA2T2 NKRF CEBPG ZNF687 ZSCAN21 BACH1 MYC RELA EVL MIR342 DEGS2 VDAC3P1 WARS YY1 ENSG00000258560 GC14M100046
GH14J100078 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -27.8 -27832 7.4 MLLT1 IKZF1 ZBTB8A ZBTB33 ZNF600 PRDM10 ZIC2 REST PKNOX1 HDAC1 MIR342 EVL ENSG00000258581 YY1 ENSG00000258560 GC14P100099
GH14J100014 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11 -91.4 -91368 7.2 ELF3 NCOA3 TFE3 SP1 PPARG FOSL2 IKZF1 CREB1 RXRA ZBTB33 MIR342 DEGS2 EVL VDAC3P1 GC14P100004 GC14M100036
GH14J100058 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.1 -50.2 -50187 4.5 MTA3 ZNF687 NFIB NCOA3 MLLT1 CREB1 ZBTB33 IKZF2 TARDBP TRIM22 MIR342 CCNK EVL ENSG00000247970 GC14M100046 ENSG00000258560
GH14J100192 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 10.9 +83.4 83393 1.8 SP1 CTCF CC2D1A ZFX ELF3 MNT CBFA2T2 MLLT1 ZNF121 CEBPG GC14M100193 GC14M100192 GC14M100190 DEGS2 YY1 MIR342 SLC25A29 ENSG00000258581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR342 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR342 Gene

Genomic Locations for MIR342 Gene
chr14:100,109,655-100,109,753
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr14:100,575,992-100,576,090
(GRCh37/hg19)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR342 Gene

Genes around MIR342 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR342 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR342 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR342 Gene

Proteins for MIR342 Gene

Post-translational modifications for MIR342 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR342 Gene

Domains & Families for MIR342 Gene

Gene Families for MIR342 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR342: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR342 Gene

Function for MIR342 Gene

Phenotypes From GWAS Catalog for MIR342 Gene

Gene Ontology (GO) - Molecular Function for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26857067
genes like me logo Genes that share ontologies with MIR342: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR342 Gene

Localization for MIR342 Gene

Gene Ontology (GO) - Cellular Components for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR342: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR342 Gene

Pathways & Interactions for MIR342 Gene

PathCards logo

SuperPathways for MIR342 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR342: view

Pathways by source for MIR342 Gene

1 KEGG pathway for MIR342 Gene

Interacting Proteins for MIR342 Gene

Gene Ontology (GO) - Biological Process for MIR342 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 26857067
GO:0035195 gene silencing by miRNA IEA,IDA --
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26857067
GO:0051898 negative regulation of protein kinase B signaling IDA 26857067
GO:0062000 positive regulation of cardiac endothelial to mesenchymal transition IDA 26857067
genes like me logo Genes that share ontologies with MIR342: view

No data available for SIGNOR curated interactions for MIR342 Gene

Drugs & Compounds for MIR342 Gene

No Compound Related Data Available

Transcripts for MIR342 Gene

mRNA/cDNA for MIR342 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR342 Gene

No ASD Table

Relevant External Links for MIR342 Gene

GeneLoc Exon Structure for
MIR342
ECgene alternative splicing isoforms for
MIR342

Expression for MIR342 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR342 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR342 Gene:

MIR342
genes like me logo Genes that share expression patterns with MIR342: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR342 Gene

Orthologs for MIR342 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR342 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-342 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir342 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-342 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-342 35
  • 81 (a)
OneToOne
Species where no ortholog for MIR342 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR342 Gene

ENSEMBL:
Gene Tree for MIR342 (if available)
TreeFam:
Gene Tree for MIR342 (if available)

Paralogs for MIR342 Gene

No data available for Paralogs for MIR342 Gene

Variants for MIR342 Gene

Sequence variations from dbSNP and Humsavar for MIR342 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000327153 -- 100,109,081(+) G/A upstream_transcript_variant
rs1002916669 -- 100,108,234(+) C/G upstream_transcript_variant
rs1005124179 -- 100,109,819(+) G/A downstream_transcript_variant
rs1007189818 -- 100,109,768(+) A/G downstream_transcript_variant
rs1010385482 -- 100,109,407(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR342 Gene

Variant ID Type Subtype PubMed ID
nsv527130 CNV loss 19592680
nsv832874 CNV loss 17160897

Additional Variant Information for MIR342 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR342

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR342 Gene

Disorders for MIR342 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR342 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
colorectal cancer
  • crc
acute promyelocytic leukemia
  • apl
myeloma, multiple
  • multiple myeloma, susceptibility to
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR342

genes like me logo Genes that share disorders with MIR342: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR342 Gene

Publications for MIR342 Gene

  1. microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells. (PMID: 30678643) Cui Z … Zhao Y (BMC cancer 2019) 3 58
  2. miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth. (PMID: 30520388) Lindholm EM … Kleivi K (MicroRNA (Shariqah, United Arab Emirates) 2019) 3 58
  3. MicroRNA‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42. (PMID: 30106159) Shi L … Mai S (Oncology reports 2018) 3 58
  4. MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance. (PMID: 29464002) Lai X … Vera J (Theranostics 2018) 3 58
  5. Epigenetic silencing of EVL/miR-342 in multiple myeloma. (PMID: 29242101) Li Z … Chim CS (Translational research : the journal of laboratory and clinical medicine 2018) 3 58

Products for MIR342 Gene

Sources for MIR342 Gene

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