microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR33B Gene

Subcategory (RNA class) for MIR33B Gene

miRNA

Aliases for MIR33B Gene

External Ids for MIR33B Gene

Previous HGNC Symbols for MIR33B Gene

  • MIRN33B

Previous GeneCards Identifiers for MIR33B Gene

  • GC17M017659
  • GC17M017717

Summaries for MIR33B Gene

Entrez Gene Summary for MIR33B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33B Gene

MIR33B (MicroRNA 33b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR33B include Smith-Magenis Syndrome and Juxtacortical Chondrosarcoma. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Nuclear Receptors in Lipid Metabolism and Toxicity.

Rfam classification for MIR33B Gene

Additional gene information for MIR33B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33B Gene

Genomics for MIR33B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR33B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J017815 Enhancer 0.6 ENCODE dbSUPER 250.7 -1.7 -1671 0.2 RBM22 ZFX POLR2A HSALNG0114983 HSALNG0114984 HSALNG0114985 MIR33B SREBF1 RAI1
GH17J017814 Enhancer 0.4 dbSUPER 250.7 -0.8 -755 0.9 POLR2A ZFX ZBTB17 HSALNG0114983 HSALNG0114984 HSALNG0114985 MIR33B MIR6777 SREBF1 RAI1
GH17J017846 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 -37.4 -37370 12.2 ZSCAN16 MXD4 CEBPA MNT IRF2 BHLHE40 CTCF ZIC2 SIN3A RAD51 lnc-SREBF1-1 TOM1L2 MIR33B RAI1 TOP3A PEMT RASD1 piR-56348 SREBF1
GH17J017689 Promoter/Enhancer 2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.2 +118.9 118909 11.4 TBP ZBTB10 SP1 BCL11A FEZF1 CEBPA NR2C1 SMAD5 ZFP64 ZNF217 SREBF1 MIR33B TOM1L2 DRC3 SHMT1 PEMT TOP3A ATPAF2 ALKBH5 FLCN
GH17J017874 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 -62.7 -62727 5.1 ZIC2 MAFF ZNF341 RXRA ZNF316 JUND ZNF2 MAFK ZNF24 HNF4A TOM1L2 SREBF1 MIR33B RAI1 DRC3 GID4 piR-42692 piR-35674-210
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR33B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR33B Gene

Latest Assembly
chr17:17,813,836-17,813,931
(GRCh38/hg38)
Size:
96 bases
Orientation:
Minus strand

Previous Assembly
chr17:17,717,150-17,717,245
(GRCh37/hg19 by Entrez Gene)
Size:
96 bases
Orientation:
Minus strand

chr17:17,717,150-17,717,245
(GRCh37/hg19 by Ensembl)
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR33B Gene

Genes around MIR33B on UCSC Golden Path with GeneCards custom track
MIR33B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33B Gene

Proteins for MIR33B Gene

Post-translational modifications for MIR33B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33B Gene

Domains & Families for MIR33B Gene

Gene Families for MIR33B Gene

genes like me logo Genes that share domains with MIR33B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR33B Gene

Function for MIR33B Gene

Phenotypes From GWAS Catalog for MIR33B Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33B Gene

Localization for MIR33B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR33B gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR33B Gene

Pathways & Interactions for MIR33B Gene

genes like me logo Genes that share pathways with MIR33B: view

Gene Ontology (GO) - Biological Process for MIR33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 24931346
GO:0010983 positive regulation of high-density lipoprotein particle clearance IMP 24931346
GO:0035195 gene silencing by miRNA IMP 24931346
GO:0042632 cholesterol homeostasis IMP 24931346
GO:0090370 negative regulation of cholesterol efflux IMP 24931346
genes like me logo Genes that share ontologies with MIR33B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR33B Gene

Drugs & Compounds for MIR33B Gene

No Compound Related Data Available

Transcripts for MIR33B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR33B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001270D3_9606 miRNA 22 5

RefSeq: NR_030361,

LncBase: hsa-miR-33b-3p,

miRBase: MIMAT0004811,

TarBase: hsa-miR-33b-3p,

ENA: LM380420.1:1..22:ncRNA, LM609583.1:54..75:ncRNA,

URS00004C8DD5_9606 miRNA 20 5

RefSeq: NR_030361,

LncBase: hsa-miR-33b-5p,

miRBase: MIMAT0003301,

TarBase: hsa-miR-33b-5p,

ENA: LM379881.1:1..20:ncRNA, LM609583.1:16..35:ncRNA,

URS000075D54F_9606 precursor_RNA 96 4

RefSeq: NR_030361,

Ensembl: ENST00000385104 (view in UCSC) ,

miRBase: MI0003646,

ENA: LM609583.1:1..96:precursor_RNA,

URS00006B9362_9606 precursor_RNA 67 1

Rfam: RF00667,

URS0001BC5B8D_9606 pre_miRNA 67 1

Rfam: RF00667,

MIR33B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR33B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33B Gene

No ASD Table

Relevant External Links for MIR33B Gene

GeneLoc Exon Structure for
MIR33B

Expression for MIR33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR33B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR33B

genes like me logo Genes that share expression patterns with MIR33B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR33B Gene

Orthologs for MIR33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-33b 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-33b 31
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33a 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 65 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-33-2 31
  • 65 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 56 (a)
OneToMany
Species where no ortholog for MIR33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR33B Gene

ENSEMBL:
Gene Tree for MIR33B (if available)
TreeFam:
Gene Tree for MIR33B (if available)

Paralogs for MIR33B Gene

No data available for Paralogs for MIR33B Gene

Variants for MIR33B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR33B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR33B Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv522668 CNV loss 19592680
nsv833385 CNV loss 17160897
nsv953838 CNV deletion 24416366

Additional Variant Information for MIR33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR33B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR33B Gene

Disorders for MIR33B Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR33B Gene - From: CVR and COP

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • sms
juxtacortical chondrosarcoma
inherited metabolic disorder
  • inborn errors of metabolism
spleen angiosarcoma
  • angiosarcoma of spleen
lipid storage disease
  • inborn lipid storage disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR33B

genes like me logo Genes that share disorders with MIR33B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR33B Gene

Publications for MIR33B Gene

  1. Linc02349 promotes osteogenesis of human umbilical cord-derived stem cells by acting as a competing endogenous RNA for miR-25-3p and miR-33b-5p. (PMID: 32346990) Cao L … Shuai C (Cell proliferation 2020) 3
  2. Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma. (PMID: 31822509) Karkhanis V … Baiocchi RA (The Journal of biological chemistry 2020) 3
  3. miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway. (PMID: 31170866) Zhao L … Feng Y (Perfusion 2020) 3
  4. Upregulation of miR‑33b promotes endometriosis via inhibition of Wnt/β‑catenin signaling and ZEB1 expression. (PMID: 30664209) Zhang H … Zhang S (Molecular medicine reports 2019) 3
  5. CUL4B/miR-33b/C-MYC axis promotes prostate cancer progression. (PMID: 30609075) Zhao M … Han B (The Prostate 2019) 3

Products for MIR33B Gene

Sources for MIR33B Gene