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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR33B Gene
Subcategory (RNA class) for MIR33B Gene
miRNA
Aliases for MIR33B Gene
- MIMAT0003301 (miRBase)
- MI0003646 (miRBase)
- MIRN33B (NCBI Entrez Gene)
- Mir-33b (NCBI Entrez Gene)
- RF00667 (Rfam)
- MIR33B (Ensembl)
External Ids for MIR33B Gene
- HGNC: 32791
- NCBI Entrez Gene: 693120
- Ensembl: ENSG00000207839
- OMIM®: 613486
- miRBase: hsa-mir-33b
Previous HGNC Symbols for MIR33B Gene
- MIRN33B
Previous GeneCards Identifiers for MIR33B Gene
- GC17M017659
- GC17M017717
Summaries for MIR33B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR33B Gene
MIR33B (MicroRNA 33b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR33B include Smith-Magenis Syndrome and Juxtacortical Chondrosarcoma. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Nuclear Receptors in Lipid Metabolism and Toxicity.
Rfam classification for MIR33B Gene
-
microRNA mir-33
Additional gene information for MIR33B Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33B Gene
Genomics for MIR33B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR33B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR33B on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR33B Gene
Latest Assembly
- chr17:17,813,836-17,813,931
- (GRCh38/hg38)
- Size:
- 96 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:17,717,150-17,717,245
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 96 bases
- Orientation:
- Minus strand
- chr17:17,717,150-17,717,245
- (GRCh37/hg19 by Ensembl)
- Size:
- 96 bases
- Orientation:
- Minus strand
Genomic View for MIR33B Gene
Genes around MIR33B on UCSC Golden Path with GeneCards custom track
MIR33B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
MIR33B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR33B Gene
Proteins for MIR33B Gene
Post-translational modifications for MIR33B Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR33B Gene
Domains & Families for MIR33B Gene
Gene Families for MIR33B Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR33B Gene
Function for MIR33B Gene
Phenotypes From GWAS Catalog for MIR33B Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR33B - Starting at $85 >
- * MIR33B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR33B - Starting at $45 >
- * MIR33B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33B Gene
Localization for MIR33B Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR33B Gene
Pathways & Interactions for MIR33B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Alzheimers Disease | ||
| 2 | Nuclear Receptors in Lipid Metabolism and Toxicity | ||
| 3 | SREBF and miR33 in cholesterol and lipid homeostasis | ||
| 4 | Statin Pathway |
.71
|
|
| 5 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling | ||
Pathways by source for MIR33B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010628 | positive regulation of gene expression | IMP | 24931346 |
| GO:0010983 | positive regulation of high-density lipoprotein particle clearance | IMP | 24931346 |
| GO:0035195 | gene silencing by miRNA | IMP | 24931346 |
| GO:0042632 | cholesterol homeostasis | IMP | 24931346 |
| GO:0090370 | negative regulation of cholesterol efflux | IMP | 24931346 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR33B Gene
Transcripts for MIR33B Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR33B Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00001270D3_9606 | miRNA | 22 | 5 |
RefSeq: NR_030361, LncBase: hsa-miR-33b-3p, miRBase: MIMAT0004811, TarBase: hsa-miR-33b-3p, |
| URS00004C8DD5_9606 | miRNA | 20 | 5 |
RefSeq: NR_030361, LncBase: hsa-miR-33b-5p, miRBase: MIMAT0003301, TarBase: hsa-miR-33b-5p, |
| URS000075D54F_9606 | precursor_RNA | 96 | 4 |
RefSeq: NR_030361, Ensembl: ENST00000385104 (view in UCSC) , miRBase: MI0003646, |
| URS00006B9362_9606 | precursor_RNA | 67 | 1 |
Rfam: RF00667, |
| URS0001BC5B8D_9606 | pre_miRNA | 67 | 1 |
Rfam: RF00667, |
MIR33B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR33B Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR33B - Starting at $85 >
- * MIR33B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR33B - Starting at $45 >
- * MIR33B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR33B Gene
- GeneLoc Exon Structure for
- MIR33B
Expression for MIR33B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR33B
Primer products for research
-
OriGene qPCR primer pairs for MIR33B
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR33B Gene
Orthologs for MIR33B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-33b 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-33b 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-33b 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-33a 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-33-2 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MIR33B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for MIR33B Gene
No data available for Paralogs for MIR33B Gene
Variants for MIR33B Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR33B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR33B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR33B Gene
Disorders for MIR33B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smith-magenis syndrome |
|
|
| juxtacortical chondrosarcoma |
|
|
| inherited metabolic disorder |
|
|
| spleen angiosarcoma |
|
|
| lipid storage disease |
|
|
Search MIR33B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR33B
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR33B Gene
Publications for MIR33B Gene
- Linc02349 promotes osteogenesis of human umbilical cord-derived stem cells by acting as a competing endogenous RNA for miR-25-3p and miR-33b-5p. (PMID: 32346990) Cao L … Shuai C (Cell proliferation 2020) 3
- Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma. (PMID: 31822509) Karkhanis V … Baiocchi RA (The Journal of biological chemistry 2020) 3
- miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway. (PMID: 31170866) Zhao L … Feng Y (Perfusion 2020) 3
- Upregulation of miR‑33b promotes endometriosis via inhibition of Wnt/β‑catenin signaling and ZEB1 expression. (PMID: 30664209) Zhang H … Zhang S (Molecular medicine reports 2019) 3
- CUL4B/miR-33b/C-MYC axis promotes prostate cancer progression. (PMID: 30609075) Zhao M … Han B (The Prostate 2019) 3
ExternalLinks
Products for MIR33B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR33B
- Origene Custom Protein Services for MIR33B
- Browse OriGene Inhibitory RNA Products For MIR33B
- OriGene qPCR primer pairs for MIR33B
- Browse CRISPR knockouts for MIR33B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR33B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR33B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR33B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR33B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR33B
Sources for MIR33B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB