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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR33B (MicroRNA 33b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR33B include Smith-Magenis Syndrome and Juxtacortical Chondrosarcoma. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Nuclear Receptors in Lipid Metabolism and Toxicity.
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Alzheimers Disease | ||
2 | Nuclear Receptors in Lipid Metabolism and Toxicity | ||
3 | SREBF and miR33 in cholesterol and lipid homeostasis | ||
4 | Statin Pathway |
.71
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5 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010628 | positive regulation of gene expression | IMP | 24931346 |
GO:0010983 | positive regulation of high-density lipoprotein particle clearance | IMP | 24931346 |
GO:0035195 | gene silencing by miRNA | IMP | 24931346 |
GO:0042632 | cholesterol homeostasis | IMP | 24931346 |
GO:0090370 | negative regulation of cholesterol efflux | IMP | 24931346 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00001270D3_9606 | miRNA | 22 | 5 |
RefSeq: NR_030361, LncBase: hsa-miR-33b-3p, miRBase: MIMAT0004811, TarBase: hsa-miR-33b-3p, |
URS00004C8DD5_9606 | miRNA | 20 | 5 |
RefSeq: NR_030361, LncBase: hsa-miR-33b-5p, miRBase: MIMAT0003301, TarBase: hsa-miR-33b-5p, |
URS000075D54F_9606 | precursor_RNA | 96 | 4 |
RefSeq: NR_030361, Ensembl: ENST00000385104 (view in UCSC) , miRBase: MI0003646, |
URS00006B9362_9606 | precursor_RNA | 67 | 1 |
Rfam: RF00667, |
URS0001BC5B8D_9606 | pre_miRNA | 67 | 1 |
Rfam: RF00667, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-33b 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-33b 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-33b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-33a 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-33-2 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
smith-magenis syndrome |
|
|
juxtacortical chondrosarcoma |
|
|
inherited metabolic disorder |
|
|
spleen angiosarcoma |
|
|
lipid storage disease |
|
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