microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR33A Gene

Subcategory (RNA class) for MIR33A Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR33A Gene

  • MicroRNA 33a 2 3 5
  • Hsa-MiR-33a-3p 166 177
  • Hsa-MiR-33a-5p 166 177
  • MicroRNA 33 2 3
  • MIMAT0004506 51
  • MIMAT0000091 51
  • Hsa-Mir-33a 3
  • Hsa-Mir-33 3
  • MI0000091 51
  • MiRNA33A 3
  • Mir-33a 3
  • MIRN33A 3
  • RF00667 172
  • MiR-33 3
  • MIRN33 3
  • MIR33A 2
  • MIR33 3

External Ids for MIR33A Gene

Previous HGNC Symbols for MIR33A Gene

  • MIRN33
  • MIRN33A

Previous GeneCards Identifiers for MIR33A Gene

  • GC22P040628
  • GC22P042296

Summaries for MIR33A Gene

Entrez Gene Summary for MIR33A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33A Gene

MIR33A (MicroRNA 33a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR33A include Abdominal Obesity-Metabolic Syndrome 1 and Non-Alcoholic Fatty Liver Disease. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Statin Pathway.

Rfam classification for MIR33A Gene

Additional gene information for MIR33A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33A Gene

Genomics for MIR33A Gene

GeneHancer (GH) Regulatory Elements for MIR33A Gene

Promoters and enhancers for MIR33A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041897 Enhancer 0.6 ENCODE dbSUPER 500.7 -1.9 -1946 2.4 POLR2A POLR2G RBM22 MNT ZNF214 AJ421755 AB372797 MIR33A NDUFA6 TNFRSF13C CYP2D6 CENPM SNU13 C22orf46 SMDT1
GH22J041837 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 -57.0 -57043 12.6 ZBTB40 ZNF217 CTCF PHB2 ZIC2 ZBTB11 AFF1 TARDBP REST KLF4 CYP2D6 MEI1 DESI1 MIR33A SHISA8 TNFRSF13C CENPM RNU6ATAC22P NDUFA6 XPNPEP3
GH22J041770 Enhancer 0.6 Ensembl 10.6 -129.9 -129943 1.2 ZNF316 MAFF MAFK EBF1 MAFG JUNB ATF2 GATA3 FOS EMSY MEI1 C22orf46 SNU13 RNU6ATAC22P SREBF2 MIR33A SHISA8 CENPM DESI1 XRCC6
GH22J041776 Enhancer 0.5 Ensembl 10.6 -124.6 -124644 0.6 CTCF CREB1 ZFHX2 ZNF664 ATF2 EGR2 piR-40995 MEI1 C22orf46 SNU13 RNU6ATAC22P SREBF2 MIR33A SHISA8 CENPM DESI1
GH22J041772 Enhancer 0.4 Ensembl 10.6 -128.2 -128180 1.3 NR2F1 KDM1A FOS ZNF629 CBFA2T3 MEI1 CENPM C22orf46 SNU13 RNU6ATAC22P SREBF2 MIR33A SHISA8 DESI1 XRCC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR33A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR33A Gene

Genomic Locations for MIR33A Gene
chr22:41,900,944-41,901,012
(GRCh38/hg38)
Size:
69 bases
Orientation:
Plus strand
chr22:42,296,948-42,297,016
(GRCh37/hg19)
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR33A Gene

Genes around MIR33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33A Gene

Proteins for MIR33A Gene

Post-translational modifications for MIR33A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33A Gene

Domains & Families for MIR33A Gene

Gene Families for MIR33A Gene

genes like me logo Genes that share domains with MIR33A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR33A Gene

Function for MIR33A Gene

Phenotypes From GWAS Catalog for MIR33A Gene

Gene Ontology (GO) - Molecular Function for MIR33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20466885
genes like me logo Genes that share ontologies with MIR33A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33A Gene

Localization for MIR33A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR33A gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR33A Gene

Pathways & Interactions for MIR33A Gene

genes like me logo Genes that share pathways with MIR33A: view
;

Gene Ontology (GO) - Biological Process for MIR33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 23536474
GO:0010983 positive regulation of high-density lipoprotein particle clearance ISS 20466885
GO:0035195 gene silencing by miRNA IMP 20855588
GO:0038027 apolipoprotein A-I-mediated signaling pathway IMP 20855588
GO:0042593 glucose homeostasis ISS --
genes like me logo Genes that share ontologies with MIR33A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR33A Gene

Drugs & Compounds for MIR33A Gene

No Compound Related Data Available

Transcripts for MIR33A Gene

mRNA/cDNA for MIR33A Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33A Gene

No ASD Table

Relevant External Links for MIR33A Gene

GeneLoc Exon Structure for
MIR33A

Expression for MIR33A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR33A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR33A

genes like me logo Genes that share expression patterns with MIR33A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR33A Gene

Orthologs for MIR33A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33a 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-33a 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-33a 31
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir33 31
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-33 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33b 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-33 31
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-33-1 31
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
Species where no ortholog for MIR33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR33A Gene

ENSEMBL:
Gene Tree for MIR33A (if available)
TreeFam:
Gene Tree for MIR33A (if available)

Paralogs for MIR33A Gene

No data available for Paralogs for MIR33A Gene

Variants for MIR33A Gene

Additional dbSNP identifiers (rs#s) for MIR33A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR33A Gene

Variant ID Type Subtype PubMed ID
esv3893484 CNV loss 25118596
nsv1057208 CNV gain 25217958
nsv508736 CNV insertion 20534489

Additional Variant Information for MIR33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR33A Gene

Disorders for MIR33A Gene

MalaCards: The human disease database

(21) MalaCards diseases for MIR33A Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR33A

genes like me logo Genes that share disorders with MIR33A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR33A Gene

Publications for MIR33A Gene

  1. Circulating miRNA-33: a potential biomarker in patients with coronary artery disease. (PMID: 30022694) Reddy LL … Ashavaid TF (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2019) 3 54
  2. Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity. (PMID: 30537863) Corona-Meraz FI … Navarro-Hernández RE (Diabetes & vascular disease research 2019) 3 54
  3. Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 macropahge-derived foam cells. (PMID: 29653102) Gao JH … Tang CK (Biochemical and biophysical research communications 2018) 3 54
  4. miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. (PMID: 28871425) Kang M … Shi J (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018) 3 54
  5. Long non-coding RNA CASC15 promotes tongue squamous carcinoma progression through targeting miR-33a-5p. (PMID: 29804249) Zuo Z … Wang Q (Environmental science and pollution research international 2018) 3 54

Products for MIR33A Gene

Sources for MIR33A Gene