microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR33A Gene

RNA type for MIR33A Gene

miRNA

Aliases for MIR33A Gene

External Ids for MIR33A Gene

Previous HGNC Symbols for MIR33A Gene

  • MIRN33
  • MIRN33A

Previous GeneCards Identifiers for MIR33A Gene

  • GC22P040628
  • GC22P042296

Summaries for MIR33A Gene

Entrez Gene Summary for MIR33A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33A Gene

MIR33A (MicroRNA 33a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR33A include Abdominal Obesity-Metabolic Syndrome 1 and Non-Alcoholic Fatty Liver Disease. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Nuclear Receptors in Lipid Metabolism and Toxicity.

Rfam classification for MIR33A Gene

Additional gene information for MIR33A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33A Gene

Genomics for MIR33A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR33A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041897 Enhancer 0.8 Ensembl ENCODE dbSUPER 250.7 -1.6 -1647 3 RBM22 NR2F6 POLR2A EGR2 MNT ZFHX2 KLF17 AB372797 MIR33A NDUFA6 TNFRSF13C CYP2D6 CENPM SNU13 C22orf46 SMDT1 RNU6ATAC22P
GH22J041840 Enhancer 0.7 ENCODE dbSUPER 12.6 -59.8 -59772 1.8 TEAD3 SCRT1 ZNF18 KLF1 ZNF579 PRDM10 NR2F2 SCRT2 POLR2A MIR33A SHISA8 CENPM RNU6ATAC22P CYP2D6 MEI1 NDUFA6 SREBF2 piR-57460-461 FJ601684-304
GH22J041770 Enhancer 0.5 Ensembl 10.6 -129.9 -129943 1.2 MAFF ZNF316 EBF1 MAFK MAFG ATF2 JUNB EMSY MEI1 SNU13 C22orf46 RNU6ATAC22P SREBF2 MIR33A SHISA8 CENPM XRCC6 DESI1
GH22J041776 Enhancer 0.5 Ensembl 10.6 -124.6 -124644 0.6 CTCF ZNF664 ATF2 EGR2 CREB1 ZFHX2 piR-40995 MEI1 SNU13 C22orf46 RNU6ATAC22P SREBF2 MIR33A SHISA8 CENPM XRCC6
GH22J041772 Enhancer 0.4 Ensembl 10.6 -128.1 -128144 0.8 NR2F1 KDM1A ZNF629 CBFA2T3 MEI1 CENPM SNU13 C22orf46 RNU6ATAC22P SREBF2 MIR33A SHISA8 DESI1 XRCC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR33A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR33A Gene

Latest Assembly
chr22:41,900,944-41,901,012
(GRCh38/hg38)
Size:
69 bases
Orientation:
Plus strand

Previous Assembly
chr22:42,296,948-42,297,016
(GRCh37/hg19 by Entrez Gene)
Size:
69 bases
Orientation:
Plus strand

chr22:42,296,948-42,297,016
(GRCh37/hg19 by Ensembl)
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR33A Gene

Genes around MIR33A on UCSC Golden Path with GeneCards custom track
MIR33A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33A Gene

Proteins for MIR33A Gene

Post-translational modifications for MIR33A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33A Gene

Domains & Families for MIR33A Gene

Gene Families for MIR33A Gene

genes like me logo Genes that share domains with MIR33A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR33A Gene

Function for MIR33A Gene

Phenotypes From GWAS Catalog for MIR33A Gene

Gene Ontology (GO) - Molecular Function for MIR33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20466885
genes like me logo Genes that share ontologies with MIR33A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33A Gene

Localization for MIR33A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR33A gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR33A Gene

Pathways & Interactions for MIR33A Gene

genes like me logo Genes that share pathways with MIR33A: view

Gene Ontology (GO) - Biological Process for MIR33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 23536474
GO:0010983 positive regulation of high-density lipoprotein particle clearance ISS 20466885
GO:0035195 gene silencing by miRNA IMP 20855588
GO:0038027 apolipoprotein A-I-mediated signaling pathway IMP 20855588
GO:0042593 glucose homeostasis ISS --
genes like me logo Genes that share ontologies with MIR33A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR33A Gene

Drugs & Compounds for MIR33A Gene

No Compound Related Data Available

Transcripts for MIR33A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR33A Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000483184_9606 miRNA 21 6

RefSeq: NR_029507,

LncBase: hsa-miR-33a-5p,

miRBase: MIMAT0000091,

MirGeneDB: Hsa-Mir-33-P1_5p,

TarBase: hsa-miR-33a-5p,

ENA: LM378778.1:1..21:ncRNA, LM608180.1:6..26:ncRNA,

URS00000CBE63_9606 pre_miRNA 69 5

RefSeq: NR_029507,

Ensembl: ENST00000385197 (view in UCSC) ,

miRBase: MI0000091,

Rfam: RF00667,

ENA: LM608180.1:1..69:precursor_RNA,

URS00003E3B82_9606 miRNA 22 5

RefSeq: NR_029507,

LncBase: hsa-miR-33a-3p,

miRBase: MIMAT0004506,

TarBase: hsa-miR-33a-3p,

ENA: LM380185.1:1..22:ncRNA, LM608180.1:46..67:ncRNA,

URS0001BC5DCC_9606 pre_miRNA 69 1

Rfam: RF00667,

URS0000EFECA2_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-33-P1,

MIR33A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR33A Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33A Gene

No ASD Table

Relevant External Links for MIR33A Gene

GeneLoc Exon Structure for
MIR33A

Expression for MIR33A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR33A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR33A

Evidence on tissue expression from TISSUES for MIR33A Gene

  • Liver(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR33A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR33A Gene

Orthologs for MIR33A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33a 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-33a 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-33a 30
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir33 30
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-33 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33b 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-33 30
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-33-1 30
  • 64 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 51 (a)
OneToMany
Species where no ortholog for MIR33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR33A Gene

ENSEMBL:
Gene Tree for MIR33A (if available)
TreeFam:
Gene Tree for MIR33A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR33A

Paralogs for MIR33A Gene

No data available for Paralogs for MIR33A Gene

Variants for MIR33A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR33A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR33A Gene

Variant ID Type Subtype PubMed ID
esv3893484 CNV loss 25118596
nsv1057208 CNV gain 25217958
nsv508736 CNV insertion 20534489

Additional Variant Information for MIR33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR33A
Leiden Open Variation Database (LOVD)
MIR33A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR33A Gene

Disorders for MIR33A Gene

MalaCards: The human disease database

(17) MalaCards diseases for MIR33A Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR33A

genes like me logo Genes that share disorders with MIR33A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR33A Gene

Publications for MIR33A Gene

  1. MiR-33 contributes to the regulation of cholesterol homeostasis. (PMID: 20466885) Rayner KJ … Fernández-Hernando C (Science (New York, N.Y.) 2010) 3 72
  2. MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients. (PMID: 31294459) D'Onofrio N … Marfella R (Journal of cellular physiology 2020) 3
  3. miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway. (PMID: 31170866) Zhao L … Feng Y (Perfusion 2020) 3
  4. Association between the transporters ABCA1/G1 and the expression of miR-33a/144 and the carotid intima media thickness in patients with arterial hypertension. (PMID: 31853766) Huesca-Gómez C … Gamboa R (Molecular biology reports 2020) 3
  5. lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling. (PMID: 31941509) Pan J … Gong Z (Molecular cancer 2020) 3

Products for MIR33A Gene

Sources for MIR33A Gene