microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR339 Gene

Subcategory (RNA class) for MIR339 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR339 Gene

  • MicroRNA 339 2 3 5
  • Hsa-MiR-339-5p 166 177
  • Hsa-MiR-339-3p 166 177
  • MIMAT0000764 51
  • MIMAT0004702 51
  • Hsa-Mir-339 3
  • MI0000815 51
  • Mir-339 3
  • MIRN339 3
  • RF00763 172
  • MIR339 2

External Ids for MIR339 Gene

Previous HGNC Symbols for MIR339 Gene

  • MIRN339

Previous GeneCards Identifiers for MIR339 Gene

  • GC07M001030
  • GC07M001062

Summaries for MIR339 Gene

Entrez Gene Summary for MIR339 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR339 Gene

MIR339 (MicroRNA 339) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR339 include Pancreatitis, Hereditary and Lung Cancer.

Rfam classification for MIR339 Gene

Additional gene information for MIR339 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR339 Gene

Genomics for MIR339 Gene

GeneHancer (GH) Regulatory Elements for MIR339 Gene

Promoters and enhancers for MIR339 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR339 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR339 Gene

Genomic Locations for MIR339 Gene
chr7:1,022,932-1,023,027
(GRCh38/hg38)
Size:
96 bases
Orientation:
Minus strand
chr7:1,062,569-1,062,662
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR339 Gene

Genes around MIR339 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR339 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR339 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR339 Gene

Proteins for MIR339 Gene

Post-translational modifications for MIR339 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR339 Gene

Domains & Families for MIR339 Gene

Gene Families for MIR339 Gene

HGNC:
genes like me logo Genes that share domains with MIR339: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR339 Gene

Function for MIR339 Gene

Phenotypes From GWAS Catalog for MIR339 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR339 Gene

Localization for MIR339 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR339 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR339 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR339: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR339 Gene

Pathways & Interactions for MIR339 Gene

PathCards logo

SuperPathways for MIR339 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR339 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044344 cellular response to fibroblast growth factor stimulus ISS --
GO:1904706 negative regulation of vascular smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with MIR339: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR339 Gene

Drugs & Compounds for MIR339 Gene

No Compound Related Data Available

Transcripts for MIR339 Gene

mRNA/cDNA for MIR339 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR339 Gene

No ASD Table

Relevant External Links for MIR339 Gene

GeneLoc Exon Structure for
MIR339

Expression for MIR339 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR339 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR339

genes like me logo Genes that share expression patterns with MIR339: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR339 Gene

Orthologs for MIR339 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR339 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-339 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-339a 31
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir339 31
  • 80 (a)
OneToOne
Species where no ortholog for MIR339 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR339 Gene

ENSEMBL:
Gene Tree for MIR339 (if available)
TreeFam:
Gene Tree for MIR339 (if available)

Paralogs for MIR339 Gene

No data available for Paralogs for MIR339 Gene

Variants for MIR339 Gene

Additional dbSNP identifiers (rs#s) for MIR339 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR339 Gene

Variant ID Type Subtype PubMed ID
nsv1161477 CNV deletion 26073780
nsv464245 CNV gain 19166990
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv605720 CNV loss 21841781
nsv950784 CNV deletion 24416366

Additional Variant Information for MIR339 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR339

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR339 Gene

Disorders for MIR339 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MIR339 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • cp
lung cancer
  • adenocarcinoma of lung
colorectal cancer
  • crc
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
leukocyte disease
  • abnormality of leukocytes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR339

genes like me logo Genes that share disorders with MIR339: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR339 Gene

Publications for MIR339 Gene

  1. LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15. (PMID: 30599080) Jia YC … Zang AM (Cell biology international 2019) 3 54
  2. miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes. (PMID: 29735550) Hu T … Cowell JK (Cancer research 2018) 3 54
  3. miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1). (PMID: 30462625) Wang J … Xia S (Medical science monitor : international medical journal of experimental and clinical research 2018) 3 54
  4. Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma. (PMID: 29103767) Sun Y … Wei W (Pathology, research and practice 2018) 3 54
  5. MiR-339 depresses cell proliferation via directly targeting S-phase kinase-associated protein 2 mRNA in lung cancer. (PMID: 29377618) Ren H … Zhu H (Thoracic cancer 2018) 3 54

Products for MIR339 Gene

Sources for MIR339 Gene