microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR338 Gene

RNA type for MIR338 Gene

miRNA

Aliases for MIR338 Gene

External Ids for MIR338 Gene

Previous HGNC Symbols for MIR338 Gene

  • MIRN338

Previous GeneCards Identifiers for MIR338 Gene

  • GC17M076717
  • GC17M079100
  • GC17M079105

Summaries for MIR338 Gene

Entrez Gene Summary for MIR338 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR338 Gene

MIR338 (MicroRNA 338) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR338 include Follicular Lymphoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR338 Gene

Additional gene information for MIR338 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR338 Gene

Genomics for MIR338 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR338 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081126 Promoter/Enhancer 0.7 Ensembl dbSUPER 250.7 +0.7 656 0.6 KLF1 HIC1 MIR3065 MIR338 lnc-CEP131-1 MIR657 AATK BAIAP2 SLC38A10 lnc-CEP131-2 PVALEF lnc-TMEM105-1
GH17J081127 Enhancer 0.4 Ensembl dbSUPER 250.7 -1.2 -1244 0.4 ZNF600 MIR3065 MIR338 lnc-CEP131-2 MIR657 SLC38A10 AATK PVALEF BAIAP2 lnc-TMEM105-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR338 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR338 Gene

Latest Assembly
chr17:81,125,878-81,125,957
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand

Previous Assembly
chr17:79,099,683-79,099,749
(GRCh37/hg19 by Entrez Gene)
Size:
67 bases
Orientation:
Minus strand

Genomic View for MIR338 Gene

Genes around MIR338 on UCSC Golden Path with GeneCards custom track
MIR338 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR338 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR338 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR338 Gene

Proteins for MIR338 Gene

Post-translational modifications for MIR338 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR338 Gene

Domains & Families for MIR338 Gene

Gene Families for MIR338 Gene

HGNC:
genes like me logo Genes that share domains with MIR338: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR338 Gene

Function for MIR338 Gene

Gene Ontology (GO) - Molecular Function for MIR338 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 26617808
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21671467
genes like me logo Genes that share ontologies with MIR338: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR338 Gene

Localization for MIR338 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR338 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR338 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome HDA 30871575
genes like me logo Genes that share ontologies with MIR338: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR338 Gene

Pathways & Interactions for MIR338 Gene

PathCards logo

SuperPathways for MIR338 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR338: view

Pathways by source for MIR338 Gene

1 BioSystems pathway for MIR338 Gene

Gene Ontology (GO) - Biological Process for MIR338 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 21671467
GO:0030336 negative regulation of cell migration IDA 21671467
GO:0032715 negative regulation of interleukin-6 production IDA 30871575
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1900016 negative regulation of cytokine production involved in inflammatory response IDA 30871575
genes like me logo Genes that share ontologies with MIR338: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR338 Gene

Drugs & Compounds for MIR338 Gene

No Compound Related Data Available

Transcripts for MIR338 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR338 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000254A6_9606 miRNA 22 5

RefSeq: NR_029897,

LncBase: hsa-miR-338-3p,

miRBase: MIMAT0000763,

TarBase: hsa-miR-338-3p,

ENA: LM379268.1:1..22:ncRNA, LM608732.1:42..63:ncRNA,

URS00003776C9_9606 miRNA 22 5

RefSeq: NR_029897,

LncBase: hsa-miR-338-5p,

miRBase: MIMAT0004701,

TarBase: hsa-miR-338-5p,

ENA: LM380361.1:1..22:ncRNA, LM608732.1:6..27:ncRNA,

URS000075E706_9606 pre_miRNA 67 4

RefSeq: NR_029897,

Ensembl: ENST00000636369 (view in UCSC) ,

miRBase: MI0000814,

ENA: LM608732.1:1..67:precursor_RNA,

URS000022FB85_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-338-P1_5p,

ENA: AY940863.1:1..21:ncRNA,

URS0000652257_9606 pre_miRNA 80 1

Rfam: RF00686,

MIR338 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR338 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR338 Gene

No ASD Table

Relevant External Links for MIR338 Gene

GeneLoc Exon Structure for
MIR338

Expression for MIR338 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR338 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR338

genes like me logo Genes that share expression patterns with MIR338: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR338 Gene

Orthologs for MIR338 Gene

Evolution for MIR338 Gene

ENSEMBL:
Gene Tree for MIR338 (if available)
TreeFam:
Gene Tree for MIR338 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR338

No data available for Orthologs for MIR338 Gene

Paralogs for MIR338 Gene

No data available for Paralogs for MIR338 Gene

Variants for MIR338 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR338 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR338 Gene

Variant ID Type Subtype PubMed ID
dgv3292n100 CNV gain 25217958
esv26223 CNV gain+loss 19812545
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366

Additional Variant Information for MIR338 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR338
Leiden Open Variation Database (LOVD)
MIR338

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR338 Gene

Disorders for MIR338 Gene

MalaCards: The human disease database

(66) MalaCards diseases for MIR338 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
follicular lymphoma
  • lymphoma, follicular
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
melanoma
  • malignant melanoma
leukodystrophy, demyelinating, adult-onset, autosomal dominant
  • adld
cardiovascular syphilis
  • syphilis, cardiovascular
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR338

genes like me logo Genes that share disorders with MIR338: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR338 Gene

Publications for MIR338 Gene

  1. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. (PMID: 20300657) Tie J … Fan D (PLoS genetics 2010) 2 3
  2. The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators. (PMID: 33421526) Mirzaei S … Hamblin MR (Life sciences 2021) 3
  3. CircAKT1 acts as a sponge of miR-338-3p to facilitate clear cell renal cell carcinoma progression by up-regulating CAV1. (PMID: 32900491) Zhu Q … Yang Y (Biochemical and biophysical research communications 2020) 3
  4. miR-338-5p Targets Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 to Inhibit the Growth and Invasion of Trophoblast Cells in Selective Intrauterine Growth Restriction. (PMID: 32056133) Wen H … Yang X (Reproductive sciences (Thousand Oaks, Calif.) 2020) 3
  5. IL (Interleukin)-6 Contributes to Deep Vein Thrombosis and Is Negatively Regulated by miR-338-5p. (PMID: 31852218) Zhang Y … Li X (Arteriosclerosis, thrombosis, and vascular biology 2020) 3

Products for MIR338 Gene

Sources for MIR338 Gene