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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR338 (MicroRNA 338) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR338 include Follicular Lymphoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J081126 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 600.7 | +0.7 | 656 | 0.6 | HIC1 KLF1 USF2 | MIR3065 MIR338 MIR657 lnc-CEP131-1 AATK BAIAP2 SLC38A10 lnc-CEP131-2 PVALEF lnc-TMEM105-1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21671467 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:0070062 | extracellular exosome | HDA | 30871575 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010629 | negative regulation of gene expression | IDA | 21671467 |
GO:0030336 | negative regulation of cell migration | IDA | 21671467 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0045409 | negative regulation of interleukin-6 biosynthetic process | IDA | 30871575 |
GO:1900016 | negative regulation of cytokine production involved in inflammatory response | IDA | 30871575 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075E706_9606 | precursor_RNA | 67 | 5 |
HGNC: 31775, RefSeq: NR_029897, Ensembl: ENST00000636369 (view in UCSC) , miRBase: MI0000814, |
URS00000254A6_9606 | miRNA | 22 | 5 |
RefSeq: NR_029897, LncBase: hsa-miR-338-3p, miRBase: MIMAT0000763, TarBase: hsa-miR-338-3p, |
URS00003776C9_9606 | miRNA | 22 | 5 |
RefSeq: NR_029897, LncBase: hsa-miR-338-5p, miRBase: MIMAT0004701, TarBase: hsa-miR-338-5p, |
URS000022FB85_9606 | miRNA | 21 | 2 |
MirGeneDB: Hsa-Mir-338-P1_5p, ENA: AY940863.1:1..21:ncRNA, |
URS0000652257_9606 | precursor_RNA | 80 | 1 |
Rfam: RF00686, |
Disorder | Aliases | PubMed IDs |
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follicular lymphoma |
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oral squamous cell carcinoma |
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melanoma |
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leukodystrophy, demyelinating, adult-onset, autosomal dominant |
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cardiovascular syphilis |
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