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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR338 Gene
Subcategory (RNA class) for MIR338 Gene
miRNA
Quality Score for this RNA gene is
17
Aliases for MIR338 Gene
External Ids for MIR338 Gene
- HGNC: 31775
- Entrez Gene: 442906
- Ensembl: ENSG00000283604
- OMIM: 614059
- miRBase: hsa-mir-338
Previous HGNC Symbols for MIR338 Gene
- MIRN338
Previous GeneCards Identifiers for MIR338 Gene
- GC17M076717
- GC17M079100
- GC17M079105
Summaries for MIR338 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR338 Gene
MIR338 (MicroRNA 338) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR338 include Follicular Lymphoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.
Rfam classification for MIR338 Gene
-
microRNA mir-338
Additional gene information for MIR338 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR338 Gene
Genomics for MIR338 Gene
GeneHancer (GH) Regulatory Elements for MIR338 Gene
Promoters and enhancers for MIR338 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J081126 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 750.6 | +0.7 | 656 | 0.6 | HIC1 KLF1 | MIR3065 MIR338 MIR657 lnc-CEP131-1 AATK BAIAP2 SLC38A10 lnc-CEP131-2 lnc-TMEM105-1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR338 on UCSC Golden Path with GeneCards custom track
Genomic Locations for MIR338 Gene
Genomic Locations for MIR338 Gene
- chr17:81,125,878-81,125,957
- (GRCh38/hg38)
- Size:
- 80 bases
- Orientation:
- Minus strand
- chr17:79,099,683-79,099,749
- (GRCh37/hg19)
- Size:
- 67 bases
- Orientation:
- Minus strand
Genomic View for MIR338 Gene
Genes around MIR338 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
MIR338 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR338 Gene
Proteins for MIR338 Gene
Post-translational modifications for MIR338 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR338
- Origene Custom Protein Services for MIR338
No data available for DME Specific Peptides for MIR338 Gene
Domains & Families for MIR338 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR338 Gene
Function for MIR338 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21671467 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for MIR338
- Applied Biological Materials (abm): CRISPR Clones for MIR338 - Select products 50% OFF >
- * MIR338 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR338 CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR338 - Select products 50% OFF >
- * MIR338 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR338 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR338 Gene
Localization for MIR338 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0016442 | RISC complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR338 Gene
Pathways & Interactions for MIR338 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Parkinsons Disease Pathway | ||
Pathways by source for MIR338 Gene
1 BioSystems pathway for MIR338 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010629 | negative regulation of gene expression | IDA | 21671467 |
| GO:0030336 | negative regulation of cell migration | IDA | 21671467 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
No data available for SIGNOR curated interactions for MIR338 Gene
Transcripts for MIR338 Gene
mRNA/cDNA for MIR338 Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000636369 67 bps (ENST00000636369.1)
- (5) RNACentral transcripts :
- (3) miRBase transcripts :
- (6) ENA transcripts :
- (2) TarBase transcripts :
- (1) Rfam transcripts :
- (2) LncBase transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR338
- Applied Biological Materials (abm): CRISPR Clones for MIR338 - Select products 50% OFF >
- * MIR338 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR338 CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR338 - Select products 50% OFF >
- * MIR338 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR338 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MIR338 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR338 Gene:
MIR338Primer Products
-
OriGene qPCR primer pairs for MIR338
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR338 Gene
Orthologs for MIR338 Gene
No data available for Orthologs for MIR338 Gene
Paralogs for MIR338 Gene
No data available for Paralogs for MIR338 Gene
Variants for MIR338 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000140085 | -- | 81,126,020(-) | G/A | upstream_transcript_variant | |
| rs1000449700 | -- | 81,125,854(-) | C/G/T | downstream_transcript_variant | |
| rs1001322564 | -- | 81,126,426(-) | C/T | upstream_transcript_variant | |
| rs1002940336 | -- | 81,127,274(-) | C/A/G/T | upstream_transcript_variant | |
| rs1004637317 | -- | 81,125,638(-) | T/C | downstream_transcript_variant |
Additional Variant Information for MIR338 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR338
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR338 Gene
Disorders for MIR338 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| follicular lymphoma |
|
|
| oral squamous cell carcinoma |
|
|
| hepatocellular carcinoma |
|
|
| melanoma |
|
|
| lung cancer |
|
Search MIR338 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR338
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR338 Gene
Publications for MIR338 Gene
- MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. (PMID: 20300657) Tie J … Fan D (PLoS genetics 2010) 2 3 56
- microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene. (PMID: 30741252) Zhang X … Zhang J (Medical science monitor : international medical journal of experimental and clinical research 2019) 3 56
- Long noncoding RNA CRNDE promotes non-small cell lung cancer progression via sponging microRNA-338-3p. (PMID: 30554121) Jing H … Lv X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 56
- LncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis. (PMID: 30981837) Zhang Y … Zhang Q (Gene 2019) 3 56
- Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3 56
ExternalLinks
Products for MIR338 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR338
- Origene Custom Protein Services for MIR338
- Browse OriGene Inhibitory RNA Products For MIR338
- OriGene qPCR primer pairs for MIR338
- Browse CRISPR knockouts for MIR338
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR338
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR338
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR338
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR338
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR338
Sources for MIR338 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource