Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR338 Gene
RNA type for MIR338 Gene
miRNA
Aliases for MIR338 Gene
- MicroRNA 338 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-MiR-338-3p (LncBase, TarBase)
- Hsa-MiR-338-5p (LncBase, TarBase)
- Hsa-Mir-338 (HGNC, NCBI Entrez Gene)
- MIMAT0000763 (miRBase)
- MIMAT0004701 (miRBase)
- MI0000814 (miRBase)
- MIRN338 (NCBI Entrez Gene)
- Mir-338 (NCBI Entrez Gene)
- RF00686 (Rfam)
- MIR338 (Ensembl)
External Ids for MIR338 Gene
- HGNC: 31775
- NCBI Entrez Gene: 442906
- Ensembl: ENSG00000283604
- OMIM®: 614059
- miRBase: hsa-mir-338
Previous HGNC Symbols for MIR338 Gene
- MIRN338
Previous GeneCards Identifiers for MIR338 Gene
- GC17M076717
- GC17M079100
- GC17M079105
Summaries for MIR338 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR338 Gene
MIR338 (MicroRNA 338) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR338 include Follicular Lymphoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.
Rfam classification for MIR338 Gene
-
microRNA mir-338
Additional gene information for MIR338 Gene
- Alliance of Genome Resources
- Search for MIR338 at DataMed
- Search for MIR338 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR338 Gene
Genomics for MIR338 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR338 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J081126 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 250.7 | +0.7 | 656 | 0.6 | KLF1 HIC1 | MIR3065 MIR338 lnc-CEP131-1 MIR657 AATK BAIAP2 SLC38A10 lnc-CEP131-2 PVALEF lnc-TMEM105-1 | |
| GH17J081127 | Enhancer | 0.4 | Ensembl dbSUPER | 250.7 | -1.2 | -1244 | 0.4 | ZNF600 | MIR3065 MIR338 lnc-CEP131-2 MIR657 SLC38A10 AATK PVALEF BAIAP2 lnc-TMEM105-1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR338 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR338 Gene
Latest Assembly
- chr17:81,125,878-81,125,957
- (GRCh38/hg38)
- Size:
- 80 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:79,099,683-79,099,749
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 67 bases
- Orientation:
- Minus strand
Genomic View for MIR338 Gene
Genes around MIR338 on UCSC Golden Path with GeneCards custom track
MIR338 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
MIR338 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR338 Gene
Proteins for MIR338 Gene
Post-translational modifications for MIR338 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR338 Gene
Domains & Families for MIR338 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR338 Gene
Function for MIR338 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 26617808 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21671467 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR338 - Starting at $85 >
- * MIR338 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR338 - Starting at $45 >
- * MIR338 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR338 Gene
Localization for MIR338 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0070062 | extracellular exosome | HDA | 30871575 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR338 Gene
Pathways & Interactions for MIR338 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Parkinsons Disease Pathway | ||
Pathways by source for MIR338 Gene
1 BioSystems pathway for MIR338 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010629 | negative regulation of gene expression | IDA | 21671467 |
| GO:0030336 | negative regulation of cell migration | IDA | 21671467 |
| GO:0032715 | negative regulation of interleukin-6 production | IDA | 30871575 |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:1900016 | negative regulation of cytokine production involved in inflammatory response | IDA | 30871575 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR338 Gene
Transcripts for MIR338 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR338 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00000254A6_9606 | miRNA | 22 | 5 |
RefSeq: NR_029897, LncBase: hsa-miR-338-3p, miRBase: MIMAT0000763, TarBase: hsa-miR-338-3p, |
| URS00003776C9_9606 | miRNA | 22 | 5 |
RefSeq: NR_029897, LncBase: hsa-miR-338-5p, miRBase: MIMAT0004701, TarBase: hsa-miR-338-5p, |
| URS000075E706_9606 | pre_miRNA | 67 | 4 |
RefSeq: NR_029897, Ensembl: ENST00000636369 (view in UCSC) , miRBase: MI0000814, |
| URS000022FB85_9606 | miRNA | 21 | 2 |
MirGeneDB: Hsa-Mir-338-P1_5p, ENA: AY940863.1:1..21:ncRNA, |
| URS0000652257_9606 | pre_miRNA | 80 | 1 |
Rfam: RF00686, |
MIR338 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR338 Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR338 - Starting at $85 >
- * MIR338 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR338 - Starting at $45 >
- * MIR338 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR338 Gene
- GeneLoc Exon Structure for
- MIR338
Expression for MIR338 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR338
Primer products for research
-
OriGene qPCR primer pairs for MIR338
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR338 Gene
Orthologs for MIR338 Gene
Evolution for MIR338 Gene
- ENSEMBL:
- Gene Tree for MIR338 (if available)
- TreeFam:
- Gene Tree for MIR338 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR338
No data available for Orthologs for MIR338 Gene
Paralogs for MIR338 Gene
No data available for Paralogs for MIR338 Gene
Variants for MIR338 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR338 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR338 Gene
Disorders for MIR338 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| follicular lymphoma |
|
|
| oral squamous cell carcinoma |
|
|
| melanoma |
|
|
| leukodystrophy, demyelinating, adult-onset, autosomal dominant |
|
|
| cardiovascular syphilis |
|
|
Search MIR338 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR338
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR338 Gene
Publications for MIR338 Gene
- MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. (PMID: 20300657) Tie J … Fan D (PLoS genetics 2010) 2 3
- The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators. (PMID: 33421526) Mirzaei S … Hamblin MR (Life sciences 2021) 3
- CircAKT1 acts as a sponge of miR-338-3p to facilitate clear cell renal cell carcinoma progression by up-regulating CAV1. (PMID: 32900491) Zhu Q … Yang Y (Biochemical and biophysical research communications 2020) 3
- miR-338-5p Targets Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 to Inhibit the Growth and Invasion of Trophoblast Cells in Selective Intrauterine Growth Restriction. (PMID: 32056133) Wen H … Yang X (Reproductive sciences (Thousand Oaks, Calif.) 2020) 3
- IL (Interleukin)-6 Contributes to Deep Vein Thrombosis and Is Negatively Regulated by miR-338-5p. (PMID: 31852218) Zhang Y … Li X (Arteriosclerosis, thrombosis, and vascular biology 2020) 3
ExternalLinks
Products for MIR338 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR338
- Origene Custom Protein Services for MIR338
- Browse OriGene Inhibitory RNA Products For MIR338
- OriGene qPCR primer pairs for MIR338
- Browse CRISPR knockouts for MIR338
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR338
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR338
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR338
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR338
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR338
Sources for MIR338 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources