microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR337 Gene

Subcategory (RNA class) for MIR337 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR337 Gene

  • MicroRNA 337 2 3 5
  • Hsa-MiR-337-5p 163 173
  • Hsa-MiR-337-3p 163 173
  • Hsa-Mir-337 2 3
  • MIR337 2 5
  • Hsa-Mir-337-V2 178
  • Hsa-Mir-337-V1 178
  • MIMAT0004695 50
  • MIMAT0000754 50
  • MI0000806 50
  • MIRN337 3
  • Mir-337 3
  • RF00765 168

External Ids for MIR337 Gene

Previous HGNC Symbols for MIR337 Gene

  • MIRN337

Previous GeneCards Identifiers for MIR337 Gene

  • GC14P100414
  • GC14P101342
  • GC14P101217
  • GC14P101798
  • GC14P103611
  • GC14P103828
  • GC14P104102
  • GC14P104446
  • GC14P102091
  • GC14P102326
  • GC14P102496
  • GC14P102672
  • GC14P102844
  • GC14P103020
  • GC14P103215
  • GC14P103431

Summaries for MIR337 Gene

Entrez Gene Summary for MIR337 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR337 Gene

MIR337 (MicroRNA 337) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR337 include Ovarian Cancer and Oral Squamous Cell Carcinoma.

Rfam classification for MIR337 Gene

Additional gene information for MIR337 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR337 Gene

Genomics for MIR337 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR337 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR337 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR337 Gene

Genomic Locations for MIR337 Gene
chr14:100,874,490-100,874,585
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr14:101,340,830-101,340,922
(GRCh37/hg19)
Size:
93 bases
Orientation:
Plus strand

Genomic View for MIR337 Gene

Genes around MIR337 on UCSC Golden Path with GeneCards custom track
MIR337 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR337 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR337 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR337 Gene

Proteins for MIR337 Gene

Post-translational modifications for MIR337 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR337 Gene

Domains & Families for MIR337 Gene

Gene Families for MIR337 Gene

HGNC:
genes like me logo Genes that share domains with MIR337: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR337 Gene

Function for MIR337 Gene

Phenotypes From GWAS Catalog for MIR337 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR337 Gene

Localization for MIR337 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR337 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR337 Gene

Pathways & Interactions for MIR337 Gene

PathCards logo

SuperPathways for MIR337 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR337: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR337 Gene

Drugs & Compounds for MIR337 Gene

No Compound Related Data Available

Transcripts for MIR337 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR337 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000564D66_9606 miRNA 22 6

RefSeq: NR_029889,

LncBase: hsa-miR-337-3p,

miRBase: MIMAT0000754,

MirGeneDB: Hsa-Mir-337-v2_3p,

TarBase: hsa-miR-337-3p,

ENA: LM379259.1:1..22:ncRNA, LM608724.1:61..82:ncRNA,

URS0000306C70_9606 miRNA 21 6

RefSeq: NR_029889,

LncBase: hsa-miR-337-5p,

miRBase: MIMAT0004695,

MirGeneDB: Hsa-Mir-337-v2_5p,

TarBase: hsa-miR-337-5p,

ENA: LM380356.1:1..21:ncRNA, LM608724.1:23..43:ncRNA,

URS000075CFEA_9606 precursor_RNA 93 5

HGNC: 31774,

RefSeq: NR_029889,

Ensembl: ENST00000362281 (view in UCSC) ,

miRBase: MI0000806,

ENA: LM608724.1:1..93:precursor_RNA,

URS000069AA59_9606 precursor_RNA 96 1

Rfam: RF00765,

URS0000EFEDB5_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-337-v1, Hsa-Mir-337-v2,

MIR337 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR337 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR337 Gene

No ASD Table

Relevant External Links for MIR337 Gene

GeneLoc Exon Structure for
MIR337

Expression for MIR337 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR337 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR337

genes like me logo Genes that share expression patterns with MIR337: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR337 Gene

Orthologs for MIR337 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR337 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-337 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir337 31
  • 88 (a)
OneToOne
Species where no ortholog for MIR337 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR337 Gene

ENSEMBL:
Gene Tree for MIR337 (if available)
TreeFam:
Gene Tree for MIR337 (if available)

Paralogs for MIR337 Gene

No data available for Paralogs for MIR337 Gene

Variants for MIR337 Gene

Additional dbSNP identifiers (rs#s) for MIR337 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR337 Gene

Variant ID Type Subtype PubMed ID
esv1002231 CNV insertion 20482838
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR337 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR337

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR337 Gene

Disorders for MIR337 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR337 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
smooth muscle tumor
lung cancer
  • adenocarcinoma of lung
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR337

genes like me logo Genes that share disorders with MIR337: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR337 Gene

Publications for MIR337 Gene

  1. Role of miR-337-3p and its target Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells. (PMID: 30883336) Cao XM (Cancer biomarkers : section A of Disease markers 2019) 3
  2. MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4. (PMID: 30452399) Zhuang Q … Hou J (Cancer biomarkers : section A of Disease markers 2018) 3
  3. MicroRNA-337-5p participates in the development and progression of osteosarcoma via ERBB, MAPK and VEGF pathways. (PMID: 30229817) Tian ZG … Shen PC (European review for medical and pharmacological sciences 2018) 3
  4. MicroRNA‑337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. (PMID: 29048669) Liu X … Zhao J (Oncology reports 2017) 3
  5. MiR-337-3p promotes chondrocytes proliferation and inhibits apoptosis by regulating PTEN/AKT axis in osteoarthritis. (PMID: 28931211) Huang Z … Liu J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3

Products for MIR337 Gene

Sources for MIR337 Gene