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MIR335 Gene(RNA Gene)

MicroRNA 335

GCID:
GC07P130496
GIFtS:
16
Genes Participants
UDN Logo

Aliases for MIR335 Gene

Subcategory (RNA class) for MIR335 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR335 Gene

  • MicroRNA 335 2 3 5
  • Hsa-Mir-335 3
  • MiRNA335 3
  • Mir-335 3
  • MIRN335 3

External Ids for MIR335 Gene

ORGUL Members for MIR335 Gene

Previous HGNC Symbols for MIR335 Gene

  • MIRN335

Previous GeneCards Identifiers for MIR335 Gene

  • GC07P129924
  • GC07P130135

Summaries for MIR335 Gene

Entrez Gene Summary for MIR335 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is dysregulated in a variety of cancers, including breast, colorectal, and prostate cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR335 Gene

MIR335 (MicroRNA 335) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR335 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR335 Gene

Genomics for MIR335 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR335 Gene

Promoters and enhancers for MIR335 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07I130271 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 -219.1 -219144 10.8 ATF1 PKNOX1 RAD21 HSF1 SCRT2 RCOR1 ATF7 SMARCC1 CEBPB REST MEST CPA5 CPA1 MIR335 KLHDC10 GC07M130268 CPA2 CPA4
GH07I130443 Enhancer 0.4 ENCODE 10.7 -51.2 -51189 1.9 MCM7 CTCF MEST CPA1 MIR335 CPA4 CPA2 COPG2 CEP41 ENSG00000259920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR335 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR335 Gene

Genomic Locations for MIR335 Gene
chr7:130,496,111-130,496,204
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr7:130,135,952-130,136,045
(GRCh37/hg19)

Genomic View for MIR335 Gene

Genes around MIR335 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR335 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR335 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR335 Gene

Proteins for MIR335 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR335 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR335 Gene

Domains & Families for MIR335 Gene

Gene Families for MIR335 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR335: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR335 Gene

Function for MIR335 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR335 Gene

Localization for MIR335 Gene

Gene Ontology (GO) - Cellular Components for MIR335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR335: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR335 Gene

Pathways & Interactions for MIR335 Gene

SuperPathways for MIR335 Gene

PathCards logo More details on SuperPathways for MIR335
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR335: view

Pathways by source for MIR335 Gene

1 KEGG pathway for MIR335 Gene

Interacting Proteins for MIR335 Gene

Gene Ontology (GO) - Biological Process for MIR335 Gene

None

No data available for SIGNOR curated interactions for MIR335 Gene

Drugs & Compounds for MIR335 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR335 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR335 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR335 Gene

No ASD Table

Relevant External Links for MIR335 Gene

GeneLoc Exon Structure for
MIR335
ECgene alternative splicing isoforms for
MIR335

Expression for MIR335 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR335 Gene:

MIR335
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR335 Gene

Orthologs for MIR335 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR335 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-335 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-335 34
  • 98 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-335 34
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir335 34
  • 87 (a)
 OneToOne
Species where no ortholog for MIR335 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR335 Gene

ENSEMBL:
Gene Tree for MIR335 (if available)
TreeFam:
Gene Tree for MIR335 (if available)

Paralogs for MIR335 Gene

No data available for Paralogs for MIR335 Gene

Variants for MIR335 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR335 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1006962803 -- 130,495,668(+) G/A upstream_transcript_variant
rs1007350697 -- 130,494,429(+) T/G upstream_transcript_variant
rs1010414826 -- 130,495,229(+) A/G upstream_transcript_variant
rs1010880956 -- 130,495,634(+) A/C upstream_transcript_variant
rs1013921849 -- 130,494,867(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR335 Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897

Additional Variant Information for MIR335 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR335 Gene

Disorders for MIR335 Gene

Additional Disease Information for MIR335

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR335 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR335 Gene

Publications for MIR335 Gene

  1. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. (PMID: 28751304) Oldenburg A … Collas P (The Journal of cell biology 2017) 3 58
  2. Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression. (PMID: 28618927) Li H … Lv L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  3. Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells. (PMID: 28205334) Wang Y … Zhang W (Cancer science 2017) 3 58
  4. MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. (PMID: 28008602) Martin EC … Burow ME (FEBS letters 2017) 3 58
  5. MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1. (PMID: 27871924) Luo Y … Zhang J (Gene 2017) 3 58

Products for MIR335 Gene

Sources for MIR335 Gene

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