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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is dysregulated in a variety of cancers, including breast, colorectal, and prostate cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]
MIR335 (MicroRNA 335) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR335 include Breast Cancer and Leiomyoma, Uterine. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH07J130271 | Enhancer | 1.3 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 10.4 | -219.1 | -219144 | 10.8 | CTCF ZBTB33 ATF7 IKZF1 JUND POLR2A REST ZNF24 PKNOX1 CEBPA | lnc-TMEM209-1 MEST CPA5 CPA1 MIR335 KLHDC10 CPA2 CPA4 | |
GH07J130443 | Enhancer | 0.6 | Ensembl ENCODE | 10.8 | -51.2 | -51189 | 1.9 | CTCF MCM7 RAD21 | MEST CPA1 MIR335 CPA4 CPA2 COPG2 CEP41 RF00017-6630 | |
GH07J130488 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.7 | -4.2 | -4223 | 7.8 | CTCF TEAD4 PRDM10 LEF1 IKZF1 JUND POLR2A MTA1 REST NR2C1 | MESTIT1 MEST COPG2 CPA5 ENSG00000278055 ENSG00000274500 MIR335 ENSG00000270823 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25203061 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000063D0D0_9606 | precursor_RNA | 94 | 6 |
HGNC: 31773, RefSeq: NR_029899, Ensembl: ENST00000362173 (view in UCSC) , miRBase: MI0000816, Rfam: RF00766, |
URS00005092C2_9606 | miRNA | 22 | 6 |
RefSeq: NR_029899, LncBase: hsa-miR-335-3p, miRBase: MIMAT0004703, MirGeneDB: Hsa-Mir-335_3p, TarBase: hsa-miR-335-3p, |
URS0000237AF9_9606 | miRNA | 23 | 5 |
RefSeq: NR_029899, LncBase: hsa-miR-335-5p, miRBase: MIMAT0000765, TarBase: hsa-miR-335-5p, |
URS0000EFBBCA_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-335, |
URS000075A30F_9606 | miRNA | 22 | 1 |
MirGeneDB: Hsa-Mir-335_5p, |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-335 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-335 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-335 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir335 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
leiomyoma, uterine |
|
|
facioscapulohumeral muscular dystrophy 1 |
|
|
leukemia, acute lymphoblastic |
|
|
muscular dystrophy, duchenne type |
|