microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR335 Gene

Subcategory (RNA class) for MIR335 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR335 Gene

  • MIMAT0000765 50
  • MI0000816 50
  • MiRNA335 3
  • MIRN335 3
  • Mir-335 3
  • RF00766 168

External Ids for MIR335 Gene

Previous HGNC Symbols for MIR335 Gene

  • MIRN335

Previous GeneCards Identifiers for MIR335 Gene

  • GC07P129924
  • GC07P130135

Summaries for MIR335 Gene

Entrez Gene Summary for MIR335 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is dysregulated in a variety of cancers, including breast, colorectal, and prostate cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR335 Gene

MIR335 (MicroRNA 335) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR335 include Breast Cancer and Leiomyoma, Uterine. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR335 Gene

Additional gene information for MIR335 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR335 Gene

Genomics for MIR335 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR335 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130271 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -219.1 -219144 10.8 CTCF ZBTB33 ATF7 IKZF1 JUND POLR2A REST ZNF24 PKNOX1 CEBPA lnc-TMEM209-1 MEST CPA5 CPA1 MIR335 KLHDC10 CPA2 CPA4
GH07J130443 Enhancer 0.6 Ensembl ENCODE 10.8 -51.2 -51189 1.9 CTCF MCM7 RAD21 MEST CPA1 MIR335 CPA4 CPA2 COPG2 CEP41 RF00017-6630
GH07J130488 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.7 -4.2 -4223 7.8 CTCF TEAD4 PRDM10 LEF1 IKZF1 JUND POLR2A MTA1 REST NR2C1 MESTIT1 MEST COPG2 CPA5 ENSG00000278055 ENSG00000274500 MIR335 ENSG00000270823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR335 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR335 Gene

Genomic Locations for MIR335 Gene
chr7:130,496,111-130,496,204
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr7:130,135,952-130,136,045
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR335 Gene

Genes around MIR335 on UCSC Golden Path with GeneCards custom track
MIR335 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR335 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR335 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR335 Gene

Proteins for MIR335 Gene

Post-translational modifications for MIR335 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR335 Gene

Domains & Families for MIR335 Gene

Gene Families for MIR335 Gene

HGNC:
genes like me logo Genes that share domains with MIR335: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR335 Gene

Function for MIR335 Gene

Phenotypes From GWAS Catalog for MIR335 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR335 Gene

Localization for MIR335 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR335 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR335: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR335 Gene

Pathways & Interactions for MIR335 Gene

PathCards logo

SuperPathways for MIR335 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR335: view

Pathways by source for MIR335 Gene

1 KEGG pathway for MIR335 Gene

Gene Ontology (GO) - Biological Process for MIR335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR335: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR335 Gene

Drugs & Compounds for MIR335 Gene

No Compound Related Data Available

Transcripts for MIR335 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR335 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000063D0D0_9606 precursor_RNA 94 6

HGNC: 31773,

RefSeq: NR_029899,

Ensembl: ENST00000362173 (view in UCSC) ,

miRBase: MI0000816,

Rfam: RF00766,

ENA: LM608734.1:1..94:precursor_RNA,

URS00005092C2_9606 miRNA 22 6

RefSeq: NR_029899,

LncBase: hsa-miR-335-3p,

miRBase: MIMAT0004703,

MirGeneDB: Hsa-Mir-335_3p,

TarBase: hsa-miR-335-3p,

ENA: LM380363.1:1..22:ncRNA, LM608734.1:52..73:ncRNA,

URS0000237AF9_9606 miRNA 23 5

RefSeq: NR_029899,

LncBase: hsa-miR-335-5p,

miRBase: MIMAT0000765,

TarBase: hsa-miR-335-5p,

ENA: LM379270.1:1..23:ncRNA, LM608734.1:16..38:ncRNA,

URS0000EFBBCA_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-335,

URS000075A30F_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-335_5p,

MIR335 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR335 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR335 Gene

No ASD Table

Relevant External Links for MIR335 Gene

GeneLoc Exon Structure for
MIR335

Expression for MIR335 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR335

Evidence on tissue expression from TISSUES for MIR335 Gene

  • Blood(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR335 Gene

Orthologs for MIR335 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR335 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-335 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-335 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-335 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir335 31
  • 87 (a)
OneToOne
Species where no ortholog for MIR335 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR335 Gene

ENSEMBL:
Gene Tree for MIR335 (if available)
TreeFam:
Gene Tree for MIR335 (if available)

Paralogs for MIR335 Gene

No data available for Paralogs for MIR335 Gene

Variants for MIR335 Gene

Additional dbSNP identifiers (rs#s) for MIR335 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR335 Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897

Additional Variant Information for MIR335 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR335 Gene

Disorders for MIR335 Gene

MalaCards: The human disease database

(54) MalaCards diseases for MIR335 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR335

genes like me logo Genes that share disorders with MIR335: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR335 Gene

Publications for MIR335 Gene

  1. Epigenetic silencing of microRNA-335 contributes to nasopharyngeal carcinoma metastasis. (PMID: 31732311) Yang JH … Zhang S (American journal of otolaryngology 2020) 3
  2. MicroRNA‑330‑5p inhibits osteosarcoma cell growth and invasion by targeting the proto‑oncogene survivin. (PMID: 31322187) Wang H … Fang S (Molecular medicine reports 2019) 3
  3. Overexpressing miR‑335 inhibits DU145 cell proliferation by targeting early growth response 3 in prostate cancer. (PMID: 31081063) Zhang P … Wang B (International journal of oncology 2019) 3
  4. Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. (PMID: 31257089) Wang Q … Cao H (Pathology, research and practice 2019) 3
  5. Silencing the long noncoding RNA, TINCR, a molecular sponge of miR‑335, inhibits the malignant phenotype of epithelial ovarian cancer via FGF2 suppression. (PMID: 31545411) Li R … Li Y (International journal of oncology 2019) 3

Products for MIR335 Gene

Sources for MIR335 Gene