microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR331 Gene

Subcategory (RNA class) for MIR331 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR331 Gene

  • MicroRNA 331 2 3 5
  • Hsa-MiR-331-5p 168 179
  • Hsa-MiR-331-3p 168 179
  • MIMAT0000760 53
  • MIMAT0004700 53
  • Hsa-Mir-331 3
  • MI0000812 53
  • Mir-331 3
  • MIRN331 3
  • RF00769 174
  • MIR331 2

External Ids for MIR331 Gene

Previous HGNC Symbols for MIR331 Gene

  • MIRN331

Previous GeneCards Identifiers for MIR331 Gene

  • GC12P094227
  • GC12P095702

Summaries for MIR331 Gene

Entrez Gene Summary for MIR331 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR331 Gene

MIR331 (MicroRNA 331) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR331 include Leukemia and Prostate Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR331 Gene

Additional gene information for MIR331 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR331 Gene

Genomics for MIR331 Gene

GeneHancer (GH) Regulatory Elements for MIR331 Gene

Promoters and enhancers for MIR331 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J095306 Enhancer 0.2 Ensembl 750.6 -1.9 -1919 0.2 MIR331 lnc-FGD6-5
GH12J095335 Enhancer 1 ENCODE CraniofacialAtlas 11.1 +27.8 27809 2 CTCF MIXL1 ZNF121 RAD21 SP1 ELF3 PPARG ZNF384 RXRA REST lnc-VEZT-9 MIR331 FGD6 piR-34009-008 ENSG00000257943
GH12J095340 Enhancer 1 Ensembl ENCODE 11.1 +31.9 31881 2.2 LCORL NR2F6 SOX6 RERE ELF3 MAFK TFE3 CEBPG HMG20B CEBPA MIR331 HSALNG0093228 lnc-VEZT-9 ENSG00000257943
GH12J095334 Enhancer 0.8 Ensembl ENCODE 11.1 +26.0 25981 0.8 SIN3A CTCF ZBTB33 ZNF384 REST ATF3 SP1 TCF7 RAD21 FOS piR-34009-008 MIR331 lnc-VEZT-9 ENSG00000257943
GH12J095248 Enhancer 0.7 Ensembl 10.3 -58.7 -58719 3.8 ZBTB40 ZNF121 ZNF384 MAFK PKNOX1 POLR2A ZNF316 ZNF561 ZSCAN5C OSR2 VEZT FGD6 RNU6-808P MIR331 piR-36393-112 ENSG00000202470
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR331 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR331 Gene

Genomic Locations for MIR331 Gene
chr12:95,308,420-95,308,513
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr12:95,702,196-95,702,289
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR331 Gene

Genes around MIR331 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR331 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR331 Gene

Proteins for MIR331 Gene

Post-translational modifications for MIR331 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR331 Gene

Domains & Families for MIR331 Gene

Gene Families for MIR331 Gene

HGNC:
genes like me logo Genes that share domains with MIR331: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR331 Gene

Function for MIR331 Gene

Phenotypes From GWAS Catalog for MIR331 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR331 Gene

Localization for MIR331 Gene

Gene Ontology (GO) - Cellular Components for MIR331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR331: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR331 Gene

Pathways & Interactions for MIR331 Gene

PathCards logo

SuperPathways for MIR331 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR331: view

Pathways by source for MIR331 Gene

1 KEGG pathway for MIR331 Gene

Gene Ontology (GO) - Biological Process for MIR331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR331: view

No data available for SIGNOR curated interactions for MIR331 Gene

Drugs & Compounds for MIR331 Gene

No Compound Related Data Available

Transcripts for MIR331 Gene

mRNA/cDNA for MIR331 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(6) ENA transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR331 Gene

No ASD Table

Relevant External Links for MIR331 Gene

GeneLoc Exon Structure for
MIR331
ECgene alternative splicing isoforms for
MIR331

Expression for MIR331 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR331 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR331 Gene:

MIR331
genes like me logo Genes that share expression patterns with MIR331: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR331 Gene

Orthologs for MIR331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR331 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-331 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-331 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-331 33
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir331 33
  • 95 (a)
OneToOne
Species where no ortholog for MIR331 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR331 Gene

ENSEMBL:
Gene Tree for MIR331 (if available)
TreeFam:
Gene Tree for MIR331 (if available)

Paralogs for MIR331 Gene

No data available for Paralogs for MIR331 Gene

Variants for MIR331 Gene

Sequence variations from dbSNP and Humsavar for MIR331 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001853226 -- 95,308,209(+) G/A upstream_transcript_variant
rs1002284554 -- 95,307,836(+) A/G upstream_transcript_variant
rs1003594841 -- 95,308,089(+) T/C upstream_transcript_variant
rs1004053734 -- 95,307,623(+) C/G upstream_transcript_variant
rs1004203652 -- 95,307,140(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR331 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Additional Variant Information for MIR331 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR331

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR331 Gene

Disorders for MIR331 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR331 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
leukemia
  • leukemias
prostate cancer
  • prostate cancer, somatic
muscular dystrophy, duchenne type
  • dmd
squamous cell carcinoma, head and neck
  • hnscc
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR331

genes like me logo Genes that share disorders with MIR331: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR331 Gene

Publications for MIR331 Gene

  1. Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites. (PMID: 29367276) Wijayakumara DD … Meech R (The Journal of pharmacology and experimental therapeutics 2018) 3 56
  2. Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p. (PMID: 30029881) Liu T … Gai Y (Biochemical and biophysical research communications 2018) 3 56
  3. A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance. (PMID: 30063890) Papadopoulos EI … Scorilas A (Clinical biochemistry 2018) 3 56
  4. Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. (PMID: 28641313) Sierzega M … Richter P (British journal of cancer 2017) 3 56
  5. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. (PMID: 26002934) Zarrinpar A … Loomba R (Gut 2016) 3 56

Products for MIR331 Gene

Sources for MIR331 Gene