microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR331 Gene

Subcategory (RNA class) for MIR331 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR331 Gene

  • MIMAT0004700 50
  • MIMAT0000760 50
  • MI0000812 50
  • MIRN331 3
  • Mir-331 3
  • RF00769 168

External Ids for MIR331 Gene

Previous HGNC Symbols for MIR331 Gene

  • MIRN331

Previous GeneCards Identifiers for MIR331 Gene

  • GC12P094227
  • GC12P095702

Summaries for MIR331 Gene

Entrez Gene Summary for MIR331 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR331 Gene

MIR331 (MicroRNA 331) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR331 include Leukemia and Prostate Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR331 Gene

Additional gene information for MIR331 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR331 Gene

Genomics for MIR331 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR331 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J095306 Enhancer 0.2 Ensembl 600.7 -1.9 -1919 0.2 MIR331 lnc-FGD6-5 VEZT METAP2
GH12J095335 Enhancer 1 ENCODE CraniofacialAtlas 11.1 +27.8 27809 2 GATAD2A CTCF TEAD4 KDM1A FOXA1 POLR2A RXRB REST IRF2 SOX13 lnc-VEZT-9 MIR331 FGD6 piR-34009-008 ENSG00000257943 VEZT METAP2
GH12J095340 Enhancer 1 Ensembl ENCODE 11.1 +31.9 31881 2.2 GATAD2A TFE3 SOX13 RCOR2 RXRB CEBPA FOXK2 ETS1 TCF7 SP1 MIR331 HSALNG0093228 lnc-VEZT-9 LOC105369917 ENSG00000257943 VEZT METAP2
GH12J095334 Enhancer 0.8 Ensembl ENCODE 11.1 +26.0 25981 0.8 CTCF REST TCF7 SP1 ATF3 FOS FOSL2 SIN3A SAP130 RAD21 piR-34009-008 MIR331 lnc-VEZT-9 ENSG00000257943 VEZT METAP2
GH12J095248 Enhancer 0.7 Ensembl 10.3 -58.7 -58719 3.8 ZNF561 ZNF316 ZSCAN5C OSR2 ZBTB40 ZBTB17 ATF2 MAFG RCOR1 JUND VEZT FGD6 RNU6-808P MIR331 piR-36393-112 ENSG00000202470 METAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR331 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR331 Gene

Genomic Locations for MIR331 Gene
chr12:95,308,420-95,308,513
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr12:95,702,196-95,702,289
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR331 Gene

Genes around MIR331 on UCSC Golden Path with GeneCards custom track
MIR331 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR331 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR331 Gene

Proteins for MIR331 Gene

Post-translational modifications for MIR331 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR331 Gene

Domains & Families for MIR331 Gene

Gene Families for MIR331 Gene

HGNC:
genes like me logo Genes that share domains with MIR331: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR331 Gene

Function for MIR331 Gene

Phenotypes From GWAS Catalog for MIR331 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR331 Gene

Localization for MIR331 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR331 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR331: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR331 Gene

Pathways & Interactions for MIR331 Gene

PathCards logo

SuperPathways for MIR331 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR331: view

Pathways by source for MIR331 Gene

1 KEGG pathway for MIR331 Gene

Gene Ontology (GO) - Biological Process for MIR331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR331: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR331 Gene

Drugs & Compounds for MIR331 Gene

No Compound Related Data Available

Transcripts for MIR331 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR331 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000642F53_9606 precursor_RNA 94 6

HGNC: 31772,

RefSeq: NR_029895,

Ensembl: ENST00000362302 (view in UCSC) ,

miRBase: MI0000812,

Rfam: RF00769,

ENA: LM608730.1:1..94:precursor_RNA,

URS00001597DC_9606 miRNA 22 6

RefSeq: NR_029895,

LncBase: hsa-miR-331-5p,

miRBase: MIMAT0004700,

MirGeneDB: Hsa-Mir-331_5p,

TarBase: hsa-miR-331-5p,

ENA: AY940860.1:1..22:ncRNA, LM380360.1:1..22:ncRNA, LM608730.1:26..47:ncRNA,

URS00003DDE27_9606 miRNA 21 6

RefSeq: NR_029895,

LncBase: hsa-miR-331-3p,

miRBase: MIMAT0000760,

MirGeneDB: Hsa-Mir-331_3p,

TarBase: hsa-miR-331-3p,

ENA: LM379265.1:1..21:ncRNA, LM608730.1:61..81:ncRNA,

URS0000EFBAC2_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-331,

MIR331 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR331 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR331 Gene

No ASD Table

Relevant External Links for MIR331 Gene

GeneLoc Exon Structure for
MIR331

Expression for MIR331 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR331 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR331

genes like me logo Genes that share expression patterns with MIR331: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR331 Gene

Orthologs for MIR331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR331 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-331 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-331 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-331 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir331 31
  • 95 (a)
OneToOne
Species where no ortholog for MIR331 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR331 Gene

ENSEMBL:
Gene Tree for MIR331 (if available)
TreeFam:
Gene Tree for MIR331 (if available)

Paralogs for MIR331 Gene

No data available for Paralogs for MIR331 Gene

Variants for MIR331 Gene

Additional dbSNP identifiers (rs#s) for MIR331 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR331 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Additional Variant Information for MIR331 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR331

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR331 Gene

Disorders for MIR331 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MIR331 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR331

genes like me logo Genes that share disorders with MIR331: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR331 Gene

Publications for MIR331 Gene

  1. LncRNA GAPLINC promotes the growth and metastasis of glioblastoma by sponging miR-331-3p. (PMID: 30657584) Chen HH … Wang SJ (European review for medical and pharmacological sciences 2019) 3
  2. Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer. (PMID: 31077182) McAnena P … Kerin MJ (BMC cancer 2019) 3
  3. A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance. (PMID: 30063890) Papadopoulos EI … Scorilas A (Clinical biochemistry 2018) 3
  4. Serum miR-331-3p predicts tumor recurrence in esophageal adenocarcinoma. (PMID: 30228315) Gu J … Ye Y (Scientific reports 2018) 3
  5. miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer. (PMID: 29850766) Chen X … Huang X (Carcinogenesis 2018) 3

Products for MIR331 Gene

Sources for MIR331 Gene