microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR330 Gene

  • MicroRNA 330 2 3 5
  • Hsa-MiR-330-3p 168 179
  • Hsa-MiR-330-5p 168 179
  • MIMAT0000751 53
  • MIMAT0004693 53
  • Hsa-Mir-330 3
  • MI0000803 53
  • Mir-330 3
  • MIRN330 3
  • RF00770 174
  • MIR330 2

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142
  • GC19M045642
  • GC19M045644
  • GC19M045646
  • GC19M045607

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR330 include Follicular Lymphoma and Huntington Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR330 Gene

Additional gene information for MIR330 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

GeneHancer (GH) Regulatory Elements for MIR330 Gene

Promoters and enhancers for MIR330 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR330 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR330 Gene

Genomic Locations for MIR330 Gene
chr19:45,638,994-45,639,090
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr19:46,142,252-46,142,345
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

Proteins for MIR330 Gene

Post-translational modifications for MIR330 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

HGNC:
genes like me logo Genes that share domains with MIR330: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR330 Gene

Function for MIR330 Gene

Phenotypes From GWAS Catalog for MIR330 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR330 gene
Compartment Confidence
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR330: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR330 Gene

Pathways & Interactions for MIR330 Gene

PathCards logo

SuperPathways for MIR330 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 KEGG pathway for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR330: view

No data available for SIGNOR curated interactions for MIR330 Gene

Drugs & Compounds for MIR330 Gene

No Compound Related Data Available

Transcripts for MIR330 Gene

mRNA/cDNA for MIR330 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(6) ENA transcripts :
(2) TarBase transcripts :
(2) LncBase transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330
ECgene alternative splicing isoforms for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR330 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR330 Gene:

MIR330
genes like me logo Genes that share expression patterns with MIR330: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR330 Gene

Orthologs for MIR330 Gene

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

No data available for Orthologs for MIR330 Gene

Paralogs for MIR330 Gene

No data available for Paralogs for MIR330 Gene

Variants for MIR330 Gene

Sequence variations from dbSNP and Humsavar for MIR330 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001139067 -- 45,640,129(-) T/A/C upstream_transcript_variant
rs1001211057 -- 45,639,879(-) A/G upstream_transcript_variant
rs1002217059 -- 45,641,068(-) T/G upstream_transcript_variant
rs1002809443 -- 45,638,902(-) GGG/GG downstream_transcript_variant
rs1002927640 -- 45,639,845(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Additional Variant Information for MIR330 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR330 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
follicular lymphoma
  • lymphoma, follicular
huntington disease
  • hd
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR330

genes like me logo Genes that share disorders with MIR330: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. miR-330-3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b. (PMID: 30192404) Shen L … Wang F (Biotechnology and applied biochemistry 2019) 3 56
  2. Circ_0078767 suppresses non-small-cell lung cancer by protecting RASSF1A expression via sponging miR-330-3p. (PMID: 30507050) Chen T … Li W (Cell proliferation 2019) 3 56
  3. Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer. (PMID: 30281914) Wang Z … Liu A (IUBMB life 2018) 3 56
  4. Targeting of TRX2 by miR-330-3p in melanoma inhibits proliferation. (PMID: 30257313) Yao Y … Wei Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  5. S100A7 Regulates Ovarian Cancer Cell Metastasis and Chemoresistance Through MAPK Signaling and Is Targeted by miR-330-5p. (PMID: 29485916) Lin M … Lou G (DNA and cell biology 2018) 3 56

Products for MIR330 Gene

Sources for MIR330 Gene