microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR330 Gene

  • MicroRNA 330 2 3 5
  • Hsa-MiR-330-5p 163 173
  • Hsa-MiR-330-3p 163 173
  • Hsa-Mir-330 2 3
  • MIR330 2 5
  • Hsa-Mir-330-V2 178
  • Hsa-Mir-330-V1 178
  • MIMAT0004693 50
  • MIMAT0000751 50
  • MI0000803 50
  • MIRN330 3
  • Mir-330 3
  • RF00770 168

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142
  • GC19M045642
  • GC19M045644
  • GC19M045646
  • GC19M045651
  • GC19M045658
  • GC19M045607

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR330 include Follicular Lymphoma and Huntington Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR330 Gene

Additional gene information for MIR330 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR330 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR330 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR330 Gene

Genomic Locations for MIR330 Gene
chr19:45,638,994-45,639,090
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr19:46,142,252-46,142,345
(GRCh37/hg19)
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track
MIR330 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

Proteins for MIR330 Gene

Post-translational modifications for MIR330 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

HGNC:
genes like me logo Genes that share domains with MIR330: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR330 Gene

Function for MIR330 Gene

Phenotypes From GWAS Catalog for MIR330 Gene

Gene Ontology (GO) - Molecular Function for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing HDA 18320040
genes like me logo Genes that share ontologies with MIR330: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR330 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR330 Gene

Pathways & Interactions for MIR330 Gene

PathCards logo

SuperPathways for MIR330 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 KEGG pathway for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA HDA,IEA --
genes like me logo Genes that share ontologies with MIR330: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR330 Gene

Drugs & Compounds for MIR330 Gene

No Compound Related Data Available

Transcripts for MIR330 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR330 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A0E5_9606 precursor_RNA 94 5

HGNC: 31771,

RefSeq: NR_029886,

Ensembl: ENST00000362196 (view in UCSC) ,

miRBase: MI0000803,

ENA: LM608721.1:1..94:precursor_RNA,

URS000007A060_9606 miRNA 23 5

RefSeq: NR_029886,

LncBase: hsa-miR-330-3p,

miRBase: MIMAT0000751,

TarBase: hsa-miR-330-3p,

ENA: LM379256.1:1..23:ncRNA, LM608721.1:57..79:ncRNA,

URS00003380C1_9606 miRNA 22 5

RefSeq: NR_029886,

LncBase: hsa-miR-330-5p,

miRBase: MIMAT0004693,

TarBase: hsa-miR-330-5p,

ENA: AY940865.1:1..22:ncRNA, LM380354.1:1..22:ncRNA, LM608721.1:18..39:ncRNA,

URS000066DE63_9606 precursor_RNA 97 1

Rfam: RF00770,

URS0000EFEEB6_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-330-v1, Hsa-Mir-330-v2,

MIR330 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR330 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR330 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR330

genes like me logo Genes that share expression patterns with MIR330: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR330 Gene

Orthologs for MIR330 Gene

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

No data available for Orthologs for MIR330 Gene

Paralogs for MIR330 Gene

No data available for Paralogs for MIR330 Gene

Variants for MIR330 Gene

Additional dbSNP identifiers (rs#s) for MIR330 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Additional Variant Information for MIR330 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

MalaCards: The human disease database

(38) MalaCards diseases for MIR330 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
follicular lymphoma
  • lymphoma, follicular
huntington disease
  • hd
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
corneal dystrophy, congenital stromal
  • cscd
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR330

genes like me logo Genes that share disorders with MIR330: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. LINC00052 functions as a tumor suppressor through negatively modulating miR-330-3p in pancreatic cancer. (PMID: 30712321) Xiong X … Tao J (Journal of cellular physiology 2019) 3
  2. Long noncoding RNA LINC00488 functions as a ceRNA to regulate hepatocellular carcinoma cell growth and angiogenesis through miR-330-5. (PMID: 31005556) Gao J … Zhou F (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2019) 3
  3. Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8. (PMID: 30639194) Chen S … Wang YD (Cancer letters 2019) 3
  4. circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma. (PMID: 31511040) Chen J … Ke Y (Journal of experimental & clinical cancer research : CR 2019) 3
  5. miR-330-3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b. (PMID: 30192404) Shen L … Wang F (Biotechnology and applied biochemistry 2019) 3

Products for MIR330 Gene

Sources for MIR330 Gene