microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR326 Gene

Subcategory (RNA class) for MIR326 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR326 Gene

  • MicroRNA 326 2 3 5
  • Hsa-Mir-326 2 3 178
  • Hsa-MiR-326 163 173
  • MIR326 2 5
  • MIMAT0000756 50
  • MI0000808 50
  • MIRN326 3
  • Mir-326 3
  • RF00719 168

External Ids for MIR326 Gene

Previous HGNC Symbols for MIR326 Gene

  • MIRN326

Previous GeneCards Identifiers for MIR326 Gene

  • GC11M074725
  • GC11M075046

Summaries for MIR326 Gene

Entrez Gene Summary for MIR326 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR326 Gene

MIR326 (MicroRNA 326) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR326 include Multiple Sclerosis and Medulloblastoma. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR326 Gene

Additional gene information for MIR326 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR326 Gene

Genomics for MIR326 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR326 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J075273 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +57.6 57583 7.7 CTCF TFE3 ZNF692 JUND ZNF143 RXRB REST RAD21 TRIM22 ZNF341 ARRB1 MIR326 DGAT2 lnc-KLHL35-5 lnc-KLHL35-6 TPBGL
GH11J075311 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 12.1 +22.1 22134 3.6 PRDM10 IKZF1 PHF21A ZIC2 MTA1 REST NR2C1 DPF2 HDAC1 ZNF341 ARRB1 MIR326 ENSG00000254429 SNORD15B GDPD5 lnc-KLHL35-7 piR-45787 TPBGL
GH11J075461 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 10.3 -130.7 -130725 8.6 ATF7 TEAD4 ZNF629 IKZF1 KDM1A JUND ZIC2 NR2C1 ZNF740 SP1 KLHL35 GDPD5 SNORD15B LOC105369391 SERPINH1 MIR326 MOGAT2 lnc-KLHL35-3 ENSG00000254460
GH11J075366 Enhancer 0.9 ENCODE dbSUPER 12 -31.7 -31659 1.9 CREB1 PRDM10 TARDBP SOX6 CEBPB HMBOX1 SMARCA5 CTBP1 ESRRA ZNF217 MIR326 RPS3 SNORD15B ARRB1 piR-50437-088
GH11J075379 Enhancer 0.9 ENCODE dbSUPER 11.8 -45.5 -45527 1.6 CREB1 TEAD4 TFE3 FOXA1 PKNOX1 PBX2 TOE1 CTBP1 ZKSCAN8 TGIF2 ARRB1 MIR326 SNORD15B KLHL35 GDPD5 LOC105369391 piR-57337-009 RF00017-987 RPS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR326 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR326 Gene

Genomic Locations for MIR326 Gene
chr11:75,335,092-75,335,186
(GRCh38/hg38)
Size:
95 bases
Orientation:
Minus strand
chr11:75,046,136-75,046,230
(GRCh37/hg19)
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR326 Gene

Genes around MIR326 on UCSC Golden Path with GeneCards custom track
MIR326 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR326 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR326 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR326 Gene

Proteins for MIR326 Gene

Post-translational modifications for MIR326 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR326 Gene

Domains & Families for MIR326 Gene

Gene Families for MIR326 Gene

HGNC:
genes like me logo Genes that share domains with MIR326: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR326 Gene

Function for MIR326 Gene

Phenotypes From GWAS Catalog for MIR326 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR326 Gene

Localization for MIR326 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR326 gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR326 Gene

Pathways & Interactions for MIR326 Gene

PathCards logo

SuperPathways for MIR326 Gene

genes like me logo Genes that share pathways with MIR326: view

Pathways by source for MIR326 Gene

1 BioSystems pathway for MIR326 Gene
1 KEGG pathway for MIR326 Gene

Gene Ontology (GO) - Biological Process for MIR326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR326: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR326 Gene

Drugs & Compounds for MIR326 Gene

No Compound Related Data Available

Transcripts for MIR326 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR326 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006A8564_9606 precursor_RNA 95 6

HGNC: 31769,

RefSeq: NR_029891,

Ensembl: ENST00000362220 (view in UCSC) ,

miRBase: MI0000808,

Rfam: RF00719,

ENA: LM608726.1:1..95:precursor_RNA,

URS00000A939F_9606 miRNA 20 6

RefSeq: NR_029891,

LncBase: hsa-miR-326,

miRBase: MIMAT0000756,

MirGeneDB: Hsa-Mir-326_3p,

TarBase: hsa-miR-326,

ENA: LM379261.1:1..20:ncRNA, LM608726.1:60..79:ncRNA,

URS0000EFC584_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-326,

URS0000D53664_9606 miRNA 24 1

MirGeneDB: Hsa-Mir-326_5p,

MIR326 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR326 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR326 Gene

No ASD Table

Relevant External Links for MIR326 Gene

GeneLoc Exon Structure for
MIR326

Expression for MIR326 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR326 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR326

Evidence on tissue expression from TISSUES for MIR326 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR326: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR326 Gene

Orthologs for MIR326 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR326 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-326 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-326 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-326 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir326 31
  • 94 (a)
OneToOne
Species where no ortholog for MIR326 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR326 Gene

ENSEMBL:
Gene Tree for MIR326 (if available)
TreeFam:
Gene Tree for MIR326 (if available)

Paralogs for MIR326 Gene

No data available for Paralogs for MIR326 Gene

Variants for MIR326 Gene

Additional dbSNP identifiers (rs#s) for MIR326 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR326 Gene

Variant ID Type Subtype PubMed ID
dgv1225n100 CNV gain 25217958
nsv522447 CNV loss 19592680
nsv832211 CNV loss 17160897

Additional Variant Information for MIR326 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR326

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR326 Gene

Disorders for MIR326 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR326 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
multiple sclerosis
  • multiple sclerosis, susceptibility to
medulloblastoma
  • mdb
glioma susceptibility 1
  • glm1
primary biliary cirrhosis
  • pbc
psoriasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR326

genes like me logo Genes that share disorders with MIR326: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR326 Gene

Publications for MIR326 Gene

  1. MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure. (PMID: 31626960) Yuan W … Zou F (Gene 2020) 3
  2. HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway. (PMID: 30742932) Pan S … Jia L (Biochimica et biophysica acta. Molecular cell research 2019) 3
  3. The potential role of Ets-1 and miR-326 in CD19+B cells in the pathogenesis of patients with systemic lupus erythematosus. (PMID: 30456527) Jin L … Li X (Clinical rheumatology 2019) 3
  4. Involvement of H19/miR-326 axis in hepatocellular carcinoma development through modulating TWIST1. (PMID: 30362512) Wei LQ … Wu H (Journal of cellular physiology 2019) 3
  5. MiR-326/Sp1/KLF3: A novel regulatory axis in lung cancer progression. (PMID: 30485570) Wang R … Shu Y (Cell proliferation 2019) 3

Products for MIR326 Gene

Sources for MIR326 Gene