microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR324 Gene

Subcategory (RNA class) for MIR324 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR324 Gene

  • MIMAT0000761 50
  • MIMAT0000762 50
  • MI0000813 50
  • MIRN324 3
  • Mir-324 3

External Ids for MIR324 Gene

Previous HGNC Symbols for MIR324 Gene

  • MIRN324

Previous GeneCards Identifiers for MIR324 Gene

  • GC17M007070
  • GC17M007126

Summaries for MIR324 Gene

Entrez Gene Summary for MIR324 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR324 Gene

MIR324 (MicroRNA 324) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR324 include Medulloblastoma and Primary Biliary Cirrhosis. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR324 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR324 Gene

Genomics for MIR324 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR324 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007224 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 -1.8 -1765 0.9 RBFOX2 ZNF335 POLR2A RXRA HSALNG0114266 MIR324 EIF5A lnc-PHF23-1 ACADVL DLG4 DVL2
GH17J007225 Enhancer 0.4 Ensembl dbSUPER 600.7 -0.8 -822 0.4 RBFOX2 HSALNG0114266 MIR324 ELP5 DLG4 ACADVL DVL2
GH17J007833 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 44.4 -616.1 -616063 13.1 ZNF221 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 KDM6B CHD3 lnc-NAA38-5 lnc-KDM6B-1 DVL2 PFAS CTC1 CNTROB WRAP53 POLR2A
GH17J007233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 34.2 -14.9 -14880 12.1 ZNF221 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ZBTB33 TEAD4 PRDM10 REST DVL2 GABARAP PHF23 lnc-GABARAP-2 CNTROB WRAP53 POLR2A SNORD10 NEURL4 CYB5D1
GH17J007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 24.6 -257.5 -257488 13.1 SP1 HNRNPL CREB1 GATAD2A ZBTB33 ATF7 PRDM10 ZNF629 REST TFE3 POLR2A ZBTB4 KIAA0753 SLC35G6 DVL2 PFAS CNTROB WRAP53 ENSG00000265749 SNORD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR324 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR324 Gene

Genomic Locations for MIR324 Gene
chr17:7,223,297-7,223,379
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chr17:7,126,616-7,126,698
(GRCh37/hg19)
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR324 Gene

Genes around MIR324 on UCSC Golden Path with GeneCards custom track
MIR324 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR324 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR324 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR324 Gene

Proteins for MIR324 Gene

Post-translational modifications for MIR324 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR324 Gene

Domains & Families for MIR324 Gene

Gene Families for MIR324 Gene

HGNC:
genes like me logo Genes that share domains with MIR324: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR324 Gene

Function for MIR324 Gene

Phenotypes From GWAS Catalog for MIR324 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR324 Gene

Localization for MIR324 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR324 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR324 Gene

Pathways & Interactions for MIR324 Gene

PathCards logo

SuperPathways for MIR324 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR324: view

Pathways by source for MIR324 Gene

1 KEGG pathway for MIR324 Gene

Gene Ontology (GO) - Biological Process for MIR324 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR324 Gene

Drugs & Compounds for MIR324 Gene

No Compound Related Data Available

Transcripts for MIR324 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR324 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CFD7_9606 precursor_RNA 83 5

HGNC: 31767,

RefSeq: NR_029896,

Ensembl: ENST00000362183 (view in UCSC) ,

miRBase: MI0000813,

ENA: LM608731.1:1..83:precursor_RNA,

URS0000D50706_9606 miRNA 23 2

RefSeq: NR_029896,

miRBase: MIMAT0000762,

URS000075BEBE_9606 miRNA 22 2

RefSeq: NR_029896,

miRBase: MIMAT0000761,

URS000005481D_9606 miRNA 23 4

LncBase: hsa-miR-324-5p,

MirGeneDB: Hsa-Mir-324_5p,

TarBase: hsa-miR-324-5p,

ENA: LM379266.1:1..23:ncRNA, LM608731.1:16..38:ncRNA,

URS00004390F6_9606 miRNA 20 3

LncBase: hsa-miR-324-3p,

TarBase: hsa-miR-324-3p,

ENA: LM379267.1:1..20:ncRNA, LM608731.1:53..72:ncRNA,

MIR324 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR324 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR324 Gene

No ASD Table

Relevant External Links for MIR324 Gene

GeneLoc Exon Structure for
MIR324

Expression for MIR324 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR324 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR324

genes like me logo Genes that share expression patterns with MIR324: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR324 Gene

Orthologs for MIR324 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR324 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-324 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-324 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-324 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir324 31
  • 92 (a)
OneToOne
Species where no ortholog for MIR324 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR324 Gene

ENSEMBL:
Gene Tree for MIR324 (if available)
TreeFam:
Gene Tree for MIR324 (if available)

Paralogs for MIR324 Gene

No data available for Paralogs for MIR324 Gene

Variants for MIR324 Gene

Additional dbSNP identifiers (rs#s) for MIR324 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR324 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1962 CNV insertion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Additional Variant Information for MIR324 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR324

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR324 Gene

Disorders for MIR324 Gene

MalaCards: The human disease database

(44) MalaCards diseases for MIR324 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR324: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR324 Gene

Publications for MIR324 Gene

  1. Upregulation of miR-324-5p Inhibits Proliferation and Invasion of Colorectal Cancer Cells by Targeting ELAVL1. (PMID: 29386086) Gu C … Dong C (Oncology research 2019) 3
  2. Diagnostic Value of Circulating miR-324 for Prostate Cancer. (PMID: 30969074) Jin YY … Tong M (Clinical laboratory 2019) 3
  3. miR-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting Mtfr1. (PMID: 31066044) Chen P … Chen C (Journal of cellular physiology 2019) 3
  4. miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. (PMID: 30193893) Woods S … Young DA (Matrix biology : journal of the International Society for Matrix Biology 2019) 3
  5. MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. (PMID: 30045983) Kumar A … Kumar H (Journal of virology 2018) 3

Products for MIR324 Gene

Sources for MIR324 Gene