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Aliases for MIR324 Gene

Subcategory (RNA class) for MIR324 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR324 Gene

  • MicroRNA 324 2 3 5
  • Hsa-Mir-324 3
  • Mir-324 3
  • MIRN324 3

External Ids for MIR324 Gene

Previous HGNC Symbols for MIR324 Gene

  • MIRN324

Previous GeneCards Identifiers for MIR324 Gene

  • GC17M007070
  • GC17M007126

Summaries for MIR324 Gene

Entrez Gene Summary for MIR324 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR324 Gene

MIR324 (MicroRNA 324) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR324 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR324

Additional gene information for MIR324 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR324 Gene

Genomics for MIR324 Gene

GeneHancer (GH) Regulatory Elements for MIR324 Gene

Promoters and enhancers for MIR324 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007224 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.8 -1765 0.9 ZNF335 RXRA GC17M007224 MIR324 EIF5A GC17P007229 ACADVL DVL2
GH17I008172 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 42 -951.6 -951588 5.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 LOC105371520 GC17M008511 SNORD118 TMEM107 DVL2 CTC1 CNTROB POLR2A WRAP53 SNORD10
GH17I007684 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 42 -463.4 -463406 5.5 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 WRAP53 ENSG00000262251 GC17P007741 GC17P007745 TP53 CTC1 DVL2 PFAS SNORD10 SNORA48
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.1 -257.2 -257210 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.4 -616.4 -616350 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48 PER1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR324 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR324 Gene

Genomic Locations for MIR324 Gene
chr17:7,223,297-7,223,379
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chr17:7,126,616-7,126,698
(GRCh37/hg19)

Genomic View for MIR324 Gene

Genes around MIR324 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR324 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR324 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR324 Gene

ORGUL Member Location for MIR324 Gene

ORGUL Member Location for MIR324 gene

Proteins for MIR324 Gene

Post-translational modifications for MIR324 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR324 Gene

Domains & Families for MIR324 Gene

Gene Families for MIR324 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR324: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR324 Gene

Function for MIR324 Gene

Phenotypes From GWAS Catalog for MIR324 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR324 Gene

Localization for MIR324 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR324 Gene

Pathways & Interactions for MIR324 Gene

SuperPathways for MIR324 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR324: view

Pathways by source for MIR324 Gene

1 KEGG pathway for MIR324 Gene

Interacting Proteins for MIR324 Gene

Gene Ontology (GO) - Biological Process for MIR324 Gene

None

No data available for SIGNOR curated interactions for MIR324 Gene

Drugs & Compounds for MIR324 Gene

No Compound Related Data Available

Transcripts for MIR324 Gene

fRNAdb Secondary structures for MIR324 Gene

  • FR223933
  • hsa-mir-324_MI0000813_Homo_sapiens_miR-324_stem-loop_hairpin

mRNA/cDNA for MIR324 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR324 Gene

No ASD Table

Relevant External Links for MIR324 Gene

GeneLoc Exon Structure for
MIR324
ECgene alternative splicing isoforms for
MIR324

Expression for MIR324 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR324 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR324 Gene:

MIR324
genes like me logo Genes that share expression patterns with MIR324: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR324 Gene

Orthologs for MIR324 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR324 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-324 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-324 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-324 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir324 34
  • 92 (a)
OneToOne
Species where no ortholog for MIR324 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR324 Gene

ENSEMBL:
Gene Tree for MIR324 (if available)
TreeFam:
Gene Tree for MIR324 (if available)

Paralogs for MIR324 Gene

No data available for Paralogs for MIR324 Gene

Variants for MIR324 Gene

Sequence variations from dbSNP and Humsavar for MIR324 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1057516226 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,224,820(-) CCC/CC upstream_transcript_variant
rs1057516370 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,222,867(-) T/C downstream_transcript_variant
rs1057516519 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,223,823(-) G/A upstream_transcript_variant
rs1057516686 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,222,865(-) GG/CAC downstream_transcript_variant
rs1057516818 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,223,643(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR324 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1962 CNV insertion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Additional Variant Information for MIR324 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR324

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR324 Gene

Disorders for MIR324 Gene

Additional Disease Information for MIR324

No disorders were found for MIR324 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR324 Gene

Publications for MIR324 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. (PMID: 15800047) Cai X … Cullen BR (Proceedings of the National Academy of Sciences of the United States of America 2005) 1 3 58
  3. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J … Ruvkun G (Proceedings of the National Academy of Sciences of the United States of America 2004) 1 3 58
  4. MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling. (PMID: 28905994) Tang B … Hu Y (International journal of cancer 2018) 3 58
  5. Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. (PMID: 27057006) Szkolnicka D … Hay DC (Stem cells translational medicine 2016) 3 58

Products for MIR324 Gene

Sources for MIR324 Gene

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