microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR320B1 Gene

Subcategory (RNA class) for MIR320B1 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR320B1 Gene

  • MicroRNA 320b-1 2 3 5
  • Hsa-Mir-320b-1 2 3
  • Hsa-MiR-320b 163 173
  • MIR320B1 2 5
  • MIMAT0005792 50
  • Mir-320b-1 3
  • MIR320B-1 3
  • MIRN320B1 3
  • MI0003776 50
  • RF00736 168

External Ids for MIR320B1 Gene

Previous HGNC Symbols for MIR320B1 Gene

  • MIRN320B1

Previous GeneCards Identifiers for MIR320B1 Gene

  • GC00U922991
  • GC01P117016
  • GC01P117214

Summaries for MIR320B1 Gene

Entrez Gene Summary for MIR320B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR320B1 Gene

MIR320B1 (MicroRNA 320b-1) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR320B1 Gene

Additional gene information for MIR320B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR320B1 Gene

Genomics for MIR320B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR320B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J116671 Enhancer 1 Ensembl ENCODE 600.7 +1.9 1899 3.6 CTCF JUND FOXA1 DDX20 MTA2 ZNF143 MTA1 PATZ1 REST RAD21 MIR320B1 ATP1A1-AS1 IGSF3 LINC02868 CD2
GH01J116645 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 12.3 -24.2 -24170 4 ATF7 ZNF629 PRDM1 ZIC2 POLR2A SP1 ZNF600 CEBPA ZBTB20 RAD21 IGSF3 MIR320B1 LINC02868 CD101 RF01045-010 CD58
GH01J116823 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +154.5 154458 4.9 SP1 PRDM10 LEF1 IKZF1 JUND LARP7 DDX20 PRDM1 ZNF143 MTA2 ATP1A1-AS1 MAN1A2 IGSF3 CD2 PTGFRN MIR320B1 lnc-IGSF3-1 piR-35031-003
GH01J116693 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +23.9 23861 6 IKZF1 ZSCAN4 PKNOX1 POLR2A ZNF24 RAD21 SMARCC1 SMARCA5 ZBTB2 HDAC2 LINC02868 IGSF3 MIR320B1 CD2 LOC105378926
GH01J116586 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.1 -79.0 -79043 13 CTCF RFX1 TARDBP ZNF143 RELA ZIC2 REST RAD21 TCF12 IKZF2 RF01045-010 CD58 IGSF3 MIR320B1 LINC02868 CD101 ATP1A1 TTF2 LOC105378924
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR320B1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR320B1 Gene

Genomic Locations for MIR320B1 Gene
chr1:116,671,740-116,671,827
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand
chr1:117,214,371-117,214,449
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR320B1 Gene

Genes around MIR320B1 on UCSC Golden Path with GeneCards custom track
MIR320B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR320B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR320B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR320B1 Gene

Proteins for MIR320B1 Gene

Post-translational modifications for MIR320B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR320B1 Gene

Domains & Families for MIR320B1 Gene

Gene Families for MIR320B1 Gene

genes like me logo Genes that share domains with MIR320B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR320B1 Gene

Function for MIR320B1 Gene

Phenotypes From GWAS Catalog for MIR320B1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR320B1 Gene

Localization for MIR320B1 Gene

Gene Ontology (GO) - Cellular Components for MIR320B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR320B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR320B1 Gene

Pathways & Interactions for MIR320B1 Gene

PathCards logo

SuperPathways for MIR320B1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR320B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR320B1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR320B1 Gene

Drugs & Compounds for MIR320B1 Gene

No Compound Related Data Available

Transcripts for MIR320B1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR320B1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000058BF17_9606 miRNA 22 5

RefSeq: NR_031564, NR_031574,

LncBase: hsa-miR-320b,

miRBase: MIMAT0005792,

TarBase: hsa-miR-320b,

ENA: LM380639.1:1..22:ncRNA, LM609624.1:39..60:ncRNA, LM609637.1:72..93:ncRNA,

URS0000D560F4_9606 precursor_RNA 72 3

HGNC: 35247,

RefSeq: NR_031564,

miRBase: MI0003776,

URS000075D8C5_9606 precursor_RNA 79 2

Ensembl: ENST00000390209 (view in UCSC) ,

ENA: LM609624.1:1..79:precursor_RNA,

URS00006D2F82_9606 precursor_RNA 82 1

Rfam: RF00736,

MIR320B1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR320B1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR320B1 Gene

No ASD Table

Relevant External Links for MIR320B1 Gene

GeneLoc Exon Structure for
MIR320B1

Expression for MIR320B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR320B1

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR320B1 Gene

Orthologs for MIR320B1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR320B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-320b-1 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR320B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR320B1 Gene

ENSEMBL:
Gene Tree for MIR320B1 (if available)
TreeFam:
Gene Tree for MIR320B1 (if available)

Paralogs for MIR320B1 Gene

No data available for Paralogs for MIR320B1 Gene

Variants for MIR320B1 Gene

Additional dbSNP identifiers (rs#s) for MIR320B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR320B1 Gene

Variant ID Type Subtype PubMed ID
esv2758963 CNV gain+loss 17122850
nsv428190 CNV gain 18775914
nsv831148 CNV gain 17160897

Additional Variant Information for MIR320B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR320B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR320B1 Gene

Disorders for MIR320B1 Gene

Additional Disease Information for MIR320B1

No disorders were found for MIR320B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR320B1 Gene

Publications for MIR320B1 Gene

  1. miR-320b Is Down-Regulated in Psoriasis and Modulates Keratinocyte Proliferation by Targeting AKT3. (PMID: 30136020) Wang Y … Sun Q (Inflammation 2018) 3
  2. Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b. (PMID: 28409547) Lv GY … Zhang XL (Oncology research 2018) 3
  3. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  4. Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. (PMID: 28656255) Lv QL … Zhou HH (Oncology reports 2017) 3
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3

Products for MIR320B1 Gene

Sources for MIR320B1 Gene