microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR320A Gene

Subcategory (RNA class) for MIR320A Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR320A Gene

  • MicroRNA 320a 2 3 5
  • MicroRNA 320 2 3
  • Hsa-MiR-320a 163 173
  • Hsa-Mir-320 2 3
  • MIR320A 2 5
  • Hsa-Mir-320a 3
  • MIMAT0000510 50
  • MIMAT0037311 50
  • MI0000542 50
  • MIRN320A 3
  • Mir-320a 3
  • MIRN320 3
  • RF00736 168

External Ids for MIR320A Gene

Previous HGNC Symbols for MIR320A Gene

  • MIRN320
  • MIRN320A

Previous GeneCards Identifiers for MIR320A Gene

  • GC08M022161
  • GC08M022102
  • GC08M022245

Summaries for MIR320A Gene

Entrez Gene Summary for MIR320A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR320A Gene

MIR320A (MicroRNA 320a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR320A include Heart Disease and Cholangiocarcinoma.

Rfam classification for MIR320A Gene

Additional gene information for MIR320A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR320A Gene

Genomics for MIR320A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR320A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR320A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR320A Gene

Genomic Locations for MIR320A Gene
chr8:22,244,962-22,245,043
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr8:22,102,475-22,102,556
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR320A Gene

Genes around MIR320A on UCSC Golden Path with GeneCards custom track
MIR320A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR320A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR320A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR320A Gene

Proteins for MIR320A Gene

Post-translational modifications for MIR320A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR320A Gene

Domains & Families for MIR320A Gene

Gene Families for MIR320A Gene

genes like me logo Genes that share domains with MIR320A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR320A Gene

Function for MIR320A Gene

Gene Ontology (GO) - Molecular Function for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26395742
genes like me logo Genes that share ontologies with MIR320A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR320A Gene

Localization for MIR320A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR320A gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR320A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR320A Gene

Pathways & Interactions for MIR320A Gene

PathCards logo

SuperPathways for MIR320A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 31432141
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0030336 negative regulation of cell migration IDA 31432141
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:0045403 negative regulation of interleukin-4 biosynthetic process IDA 31432141
genes like me logo Genes that share ontologies with MIR320A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR320A Gene

Drugs & Compounds for MIR320A Gene

No Compound Related Data Available

Transcripts for MIR320A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR320A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003CF1AD_9606 miRNA 22 5

RefSeq: NR_029714,

LncBase: hsa-miR-320a,

miRBase: MIMAT0000510,

TarBase: hsa-miR-320a,

ENA: HB859654.1:1..22:misc_RNA, LM379081.1:1..22:ncRNA, LM608541.1:48..69:ncRNA,

URS00006FED78_9606 precursor_RNA 82 3

Ensembl: ENST00000385302 (view in UCSC) ,

Rfam: RF00736,

ENA: LM608541.1:1..82:precursor_RNA,

URS0000D53E88_9606 precursor_RNA 72 3

HGNC: 31632,

RefSeq: NR_029714,

miRBase: MI0000542,

URS000042A57E_9606 miRNA 22 2

RefSeq: NR_029714,

miRBase: MIMAT0037311,

URS00001B4903_9606 miRNA 23 1

ENA: AJ535829.1:1..23:ncRNA,

MIR320A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR320A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR320A Gene

No ASD Table

Relevant External Links for MIR320A Gene

GeneLoc Exon Structure for
MIR320A

Expression for MIR320A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR320A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR320A

Evidence on tissue expression from TISSUES for MIR320A Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR320A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR320A Gene

Orthologs for MIR320A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR320A Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-320 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-320a 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir320 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-320a-1 31
  • 83 (a)
OneToOne
Species where no ortholog for MIR320A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR320A Gene

ENSEMBL:
Gene Tree for MIR320A (if available)
TreeFam:
Gene Tree for MIR320A (if available)

Paralogs for MIR320A Gene

No data available for Paralogs for MIR320A Gene

Variants for MIR320A Gene

Additional dbSNP identifiers (rs#s) for MIR320A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR320A Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
esv2759604 CNV loss 17122850
nsv470205 CNV loss 18288195
nsv831264 CNV gain+loss 17160897
nsv831265 CNV loss 17160897

Additional Variant Information for MIR320A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR320A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR320A Gene

Disorders for MIR320A Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR320A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
heart disease
  • congenital heart disease
cholangiocarcinoma
  • cca
atrial standstill 1
  • atrst1
leukemia, acute myeloid
  • aml
follicular lymphoma
  • lymphoma, follicular
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR320A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR320A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR320A Gene

Publications for MIR320A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. MicroRNA-320a acts as a tumor suppressor in endometrial carcinoma by targeting IGF-1R. (PMID: 30628637) Shu S … Li R (International journal of molecular medicine 2019) 3
  3. miR‑320a upregulation contributes to the development of preeclampsia by inhibiting the growth and invasion of trophoblast cells by targeting interleukin 4. (PMID: 31432141) Xie N … Li L (Molecular medicine reports 2019) 3
  4. MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K/AKT signaling pathway. (PMID: 31301305) Kong Y … Ding SF (Experimental and molecular pathology 2019) 3
  5. Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder. (PMID: 31801218) Pisanu C … Squassina A (International journal of molecular sciences 2019) 3

Products for MIR320A Gene

Sources for MIR320A Gene