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Aliases for MIR320A Gene

Subcategory (RNA class) for MIR320A Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR320A Gene

  • MicroRNA 320a 2 3 5
  • MicroRNA 320 2 3
  • Hsa-Mir-320a 3
  • Hsa-Mir-320 3
  • Mir-320a 3
  • MIRN320A 3
  • MIRN320 3

External Ids for MIR320A Gene

Previous HGNC Symbols for MIR320A Gene

  • MIRN320
  • MIRN320A

Previous GeneCards Identifiers for MIR320A Gene

  • GC08M022161
  • GC08M022102

Summaries for MIR320A Gene

Entrez Gene Summary for MIR320A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR320A Gene

MIR320A (MicroRNA 320a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR320A include Heart Disease and Cholangiocarcinoma.

fRNAdb sequence ontologies for MIR320A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR320A

Additional gene information for MIR320A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR320A Gene

Genomics for MIR320A Gene

GeneHancer (GH) Regulatory Elements for MIR320A Gene

Promoters and enhancers for MIR320A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022243 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.1 105 4.3 MTA3 SP1 CC2D1A ZFX ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF POLR3D GC08P022245 GC08P022247 MIR320A ENSG00000253200 FAM160B2 PIWIL2 ENSG00000245025 BMP1 C8orf58
GH08J022202 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.6 +40.3 40294 3.8 ZNF121 PRDM10 GATAD2A RXRB CTBP1 JUND FOXA2 CREB1 SAP130 DPF2 PHYHIP POLR3D MIR320A BMP1 SFTPC LGI3 NPM2 ENSG00000285881
GH08J022214 Enhancer 1 Ensembl ENCODE dbSUPER 13.1 +28.9 28942 2.6 EGR1 MGA MNT POLR2A ZFHX2 ZNF592 TEAD4 EGR2 CBFA2T3 L3MBTL2 PIWIL2 POLR3D MIR320A SFTPC ENSG00000254064 LGI3 NPM2 ENSG00000251034 SORBS3 PHYHIP
GH08J022286 Enhancer 0.9 ENCODE 11.3 -42.4 -42396 1.3 CTCF ELF3 MNT ZNF121 TFE3 SP1 PPARG SP5 RAD21 IKZF1 PIWIL2 POLR3D MIR320A PHYHIP SLC39A14 SORBS3 ENSG00000251034
GH08J022312 Enhancer 1 Ensembl ENCODE 10.8 -69.0 -69022 3.7 PRDM1 SMARCA4 ATF1 HDAC1 SCRT2 SOX6 CTBP1 FOXA2 TRIM24 FOSL1 PIWIL2 SLC39A14 ENSG00000254064 MIR320A POLR3D PHYHIP PPP3CC RNU6-336P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR320A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR320A Gene

Genomic Locations for MIR320A Gene
chr8:22,244,962-22,245,043
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr8:22,102,475-22,102,556
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR320A Gene

Genes around MIR320A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR320A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR320A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR320A Gene

ORGUL Member Location for MIR320A Gene

ORGUL Member Location for MIR320A gene

Proteins for MIR320A Gene

Post-translational modifications for MIR320A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR320A Gene

Domains & Families for MIR320A Gene

Gene Families for MIR320A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR320A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR320A Gene

Function for MIR320A Gene

Gene Ontology (GO) - Molecular Function for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26395742
genes like me logo Genes that share ontologies with MIR320A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR320A Gene

Localization for MIR320A Gene

Gene Ontology (GO) - Cellular Components for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR320A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR320A Gene

Pathways & Interactions for MIR320A Gene

PathCards logo

SuperPathways for MIR320A Gene

No Data Available

Interacting Proteins for MIR320A Gene

Gene Ontology (GO) - Biological Process for MIR320A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0035195 gene silencing by miRNA IEA --
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis ISS --
genes like me logo Genes that share ontologies with MIR320A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR320A Gene

Drugs & Compounds for MIR320A Gene

No Compound Related Data Available

Transcripts for MIR320A Gene

fRNAdb Secondary structures for MIR320A Gene

  • FR135411

mRNA/cDNA for MIR320A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR320A Gene

No ASD Table

Relevant External Links for MIR320A Gene

GeneLoc Exon Structure for
MIR320A
ECgene alternative splicing isoforms for
MIR320A

Expression for MIR320A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR320A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR320A Gene:

MIR320A
genes like me logo Genes that share expression patterns with MIR320A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR320A Gene

Orthologs for MIR320A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR320A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-320 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-320a 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir320 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-320a-1 35
  • 83 (a)
OneToOne
Species where no ortholog for MIR320A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR320A Gene

ENSEMBL:
Gene Tree for MIR320A (if available)
TreeFam:
Gene Tree for MIR320A (if available)

Paralogs for MIR320A Gene

No data available for Paralogs for MIR320A Gene

Variants for MIR320A Gene

Sequence variations from dbSNP and Humsavar for MIR320A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001190133 -- 22,244,676(-) G/T downstream_transcript_variant
rs1001472735 -- 22,245,249(-) G/A/T upstream_transcript_variant
rs1001620135 -- 22,244,493(-) A/C downstream_transcript_variant
rs1002475428 -- 22,246,166(-) C/A upstream_transcript_variant
rs1002890766 -- 22,245,167(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR320A Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
esv2759604 CNV loss 17122850
nsv470205 CNV loss 18288195
nsv831264 CNV gain+loss 17160897
nsv831265 CNV loss 17160897

Additional Variant Information for MIR320A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR320A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR320A Gene

Disorders for MIR320A Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR320A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
heart disease
  • congestive heart failure
cholangiocarcinoma
  • cca
atrial standstill 1
  • atrst1
leukemia, acute myeloid
  • aml
follicular lymphoma
  • lymphoma, follicular
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR320A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR320A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR320A Gene

Publications for MIR320A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 58
  2. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K … Kozu T (Biochemical and biophysical research communications 2004) 1 3 58
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael MZ … James RJ (Molecular cancer research : MCR 2003) 1 3 58
  4. Screening of schizophrenia associated miRNAs and the regulation of miR-320a-3p on integrin β1. (PMID: 30813134) Wang Y … Huang Y (Medicine 2019) 3 58
  5. miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4. (PMID: 29484417) Xiong W … Chen D (Oncology reports 2018) 3 58

Products for MIR320A Gene

Sources for MIR320A Gene

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