microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR32 Gene

Subcategory (RNA class) for MIR32 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR32 Gene

  • MIMAT0000090 50
  • MI0000090 50
  • MiRNA32 3
  • RF00666 168
  • MIRN32 3
  • MiR-32 3

External Ids for MIR32 Gene

Previous HGNC Symbols for MIR32 Gene

  • MIRN32

Previous GeneCards Identifiers for MIR32 Gene

  • GC09M110849
  • GC09M111808

Summaries for MIR32 Gene

Entrez Gene Summary for MIR32 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR32 Gene

MIR32 (MicroRNA 32) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR32 include Myeloma, Multiple and Leiomyoma, Uterine. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR32 Gene

Additional gene information for MIR32 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR32 Gene

Genomics for MIR32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR32 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR32 Gene

Genomic Locations for MIR32 Gene
chr9:109,046,229-109,046,298
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chr9:111,808,509-111,808,578
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR32 Gene

Genes around MIR32 on UCSC Golden Path with GeneCards custom track
MIR32 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR32 Gene

Proteins for MIR32 Gene

No data available for DME Specific Peptides for MIR32 Gene

Domains & Families for MIR32 Gene

Gene Families for MIR32 Gene

HGNC:
genes like me logo Genes that share domains with MIR32: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR32 Gene

Function for MIR32 Gene

Phenotypes From GWAS Catalog for MIR32 Gene

Gene Ontology (GO) - Molecular Function for MIR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR32: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR32 Gene

Localization for MIR32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR32 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR32 Gene

Pathways & Interactions for MIR32 Gene

PathCards logo

SuperPathways for MIR32 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR32: view

Pathways by source for MIR32 Gene

1 KEGG pathway for MIR32 Gene

Gene Ontology (GO) - Biological Process for MIR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR32: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR32 Gene

Drugs & Compounds for MIR32 Gene

No Compound Related Data Available

Transcripts for MIR32 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR32 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000472EB8_9606 precursor_RNA 70 6

HGNC: 31631,

RefSeq: NR_029506,

Ensembl: ENST00000384965 (view in UCSC) ,

miRBase: MI0000090,

Rfam: RF00666,

ENA: LM608179.1:1..70:precursor_RNA,

URS00004C47FB_9606 miRNA 22 6

RefSeq: NR_029506,

LncBase: hsa-miR-32-5p,

miRBase: MIMAT0000090,

MirGeneDB: Hsa-Mir-32_5p,

TarBase: hsa-miR-32-5p,

ENA: LM378777.1:1..22:ncRNA, LM608179.1:6..27:ncRNA,

URS00002FC5B0_9606 miRNA 22 5

RefSeq: NR_029506,

LncBase: hsa-miR-32-3p,

miRBase: MIMAT0004505,

TarBase: hsa-miR-32-3p,

ENA: LM380184.1:1..22:ncRNA, LM608179.1:47..68:ncRNA,

URS0000EFCA53_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-32,

URS000039DEB8_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-32_3p,

MIR32 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR32 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR32 Gene

No ASD Table

Relevant External Links for MIR32 Gene

GeneLoc Exon Structure for
MIR32

Expression for MIR32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR32 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR32

genes like me logo Genes that share expression patterns with MIR32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR32 Gene

Orthologs for MIR32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR32 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-32 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-32 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir32 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-32 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-32 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-32 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-32 31
  • 96 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-32 31
  • 58 (a)
OneToOne
Species where no ortholog for MIR32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR32 Gene

ENSEMBL:
Gene Tree for MIR32 (if available)
TreeFam:
Gene Tree for MIR32 (if available)

Paralogs for MIR32 Gene

No data available for Paralogs for MIR32 Gene

Variants for MIR32 Gene

Additional dbSNP identifiers (rs#s) for MIR32 Gene

Additional Variant Information for MIR32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR32

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR32 Gene

Disorders for MIR32 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MIR32 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
myeloma, multiple
  • multiple myeloma, susceptibility to
leiomyoma, uterine
  • ul
pancreatic cancer
  • pancreatic carcinoma
pleural cancer
  • neoplasm of pleura
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search MIR32 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR32

genes like me logo Genes that share disorders with MIR32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR32 Gene

Publications for MIR32 Gene

  1. MiR-32 Inhibits Proliferation and Metastasis by Targeting EZH2 in Glioma. (PMID: 31138033) Zhang Y … Gong J (Technology in cancer research & treatment 2019) 3
  2. Plasma miR-32 levels in non-small cell lung cancer patients receiving platinum-based chemotherapy can predict the effectiveness and prognosis of chemotherapy. (PMID: 31626089) Xu S … Ji Q (Medicine 2019) 3
  3. MiR-32-5p influences high glucose-induced cardiac fibroblast proliferation and phenotypic alteration by inhibiting DUSP1. (PMID: 31438862) Shen J … Gong F (BMC molecular biology 2019) 3
  4. MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori. (PMID: 31749593) Feng J … Chai BF (World journal of gastroenterology 2019) 3
  5. MicroRNA-32 targeting PTEN enhances M2 macrophage polarization in the glioma microenvironment and further promotes the progression of glioma. (PMID: 31218569) Bao L … Li X (Molecular and cellular biochemistry 2019) 3

Products for MIR32 Gene

Sources for MIR32 Gene