This gene produces a long non-coding RNA that acts as a host gene for miR-31. This transcript may be involved in cellular pluripotency and regulate the differentiation of myoblasts and other tissues. This RNA was found to interact with Polycomb repressive proteins to repression transcription of genes involves in cell senescence. [provided by RefSeq, Dec 2017] See more...

Aliases for MIR31HG Gene

Subcategory (RNA class) for MIR31HG Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR31HG Gene

  • MIR31 Host Gene 2 3 5
  • MIR31 Host Gene (Non-Protein Coding) 2 3
  • MIR31HG 2 168
  • Long Noncoding HIF-1alpha Co-Activating RNA 3
  • Long Noncoding HIF-1I+/- Co-Activating RNA 3
  • Long Noncoding HIF-1α Co-Activating RNA 2
  • NONHSAG051889 92
  • HSALNG0070363 167
  • Hsa-Lnc-31 3
  • LncHIFCAR 3

External Ids for MIR31HG Gene

Previous GeneCards Identifiers for MIR31HG Gene

  • GC09M021455

Summaries for MIR31HG Gene

Entrez Gene Summary for MIR31HG Gene

  • This gene produces a long non-coding RNA that acts as a host gene for miR-31. This transcript may be involved in cellular pluripotency and regulate the differentiation of myoblasts and other tissues. This RNA was found to interact with Polycomb repressive proteins to repression transcription of genes involves in cell senescence. [provided by RefSeq, Dec 2017]

GeneCards Summary for MIR31HG Gene

MIR31HG (MIR31 Host Gene) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MIR31HG include Pancreatic Ductal Adenocarcinoma and Hirschsprung Disease 1.

Rfam classification for MIR31HG Gene

Additional gene information for MIR31HG Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR31HG Gene

Genomics for MIR31HG Gene

GeneHancer (GH) Regulatory Elements for MIR31HG Gene

Promoters and enhancers for MIR31HG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021573 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +7.9 7851 20.1 TCF12 JUND FOS CTCF ZIC2 ZBTB10 EP300 OSR2 DEK WT1 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG MIR31HG-002 piR-37026-597
GH09J021547 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +36.8 36782 14.6 TCF12 FOS ZNF10 ZIC2 POLR2A ZBTB26 EP300 HDAC2 ZNF341 ZBTB17 MIR31 IFNE piR-37026-597 MIR31HG MIR31HG-002
GH09J021562 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +23.7 23687 10.9 ATF2 SIX5 ZNF335 PRDM6 ZNF664 POLR2A TCF7L2 JUND ATF7 ZNF596 MIR31 IFNA13 MIR31HG MIR31HG-002 piR-37026-597
GH09J021542 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.3 +48.4 48402 1.5 TEAD4 POLR2A MAFK GATA2 MAFF NANOG MIR31 IFNE piR-37026-597 MIR31HG MIR31HG-002
GH09J021503 Enhancer 0.7 Ensembl ENCODE 0.2 +85.3 85266 5.8 POLR2A CEBPB JUN SPI1 RCOR1 MAFK STAT3 FOS EP300 JUND IFNWP2 IFNA8 IFNA12P IFNA20P IFNE TUBB8P1 RF00017-7472 piR-48950-210 MIR31HG MIR31HG-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR31HG on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR31HG Gene

Genomic Locations for MIR31HG Gene
chr9:21,410,969-21,591,766
(GRCh38/hg38)
Size:
180,798 bases
Orientation:
Minus strand
chr9:21,454,267-21,559,697
(GRCh37/hg19)
Size:
105,431 bases
Orientation:
Minus strand

Genomic View for MIR31HG Gene

Genes around MIR31HG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR31HG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR31HG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR31HG Gene

Proteins for MIR31HG Gene

Post-translational modifications for MIR31HG Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR31HG Gene

Domains & Families for MIR31HG Gene

genes like me logo Genes that share domains with MIR31HG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR31HG Gene

Function for MIR31HG Gene

Phenotypes From GWAS Catalog for MIR31HG Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR31HG Gene

Localization for MIR31HG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR31HG gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR31HG Gene

Pathways & Interactions for MIR31HG Gene

PathCards logo

SuperPathways for MIR31HG Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR31HG Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR31HG Gene

Drugs & Compounds for MIR31HG Gene

No Compound Related Data Available

Transcripts for MIR31HG Gene

mRNA/cDNA for MIR31HG Gene

26 RNACentral transcripts :
4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
5 NONCODE transcripts :
5 LncBook transcripts :
15 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR31HG Gene

No ASD Table

Relevant External Links for MIR31HG Gene

GeneLoc Exon Structure for
MIR31HG

Expression for MIR31HG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR31HG Gene

mRNA differential expression in normal tissues according to GTEx for MIR31HG Gene

This gene is overexpressed in Esophagus - Mucosa (x5.3) and Bladder (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR31HG

SOURCE GeneReport for Unigene cluster for MIR31HG Gene:

Hs.458096
genes like me logo Genes that share expression patterns with MIR31HG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR31HG Gene

Orthologs for MIR31HG Gene

Evolution for MIR31HG Gene

ENSEMBL:
Gene Tree for MIR31HG (if available)
TreeFam:
Gene Tree for MIR31HG (if available)

No data available for Orthologs for MIR31HG Gene

Paralogs for MIR31HG Gene

No data available for Paralogs for MIR31HG Gene

Variants for MIR31HG Gene

Additional dbSNP identifiers (rs#s) for MIR31HG Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR31HG Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2752289 CNV gain 17911159
esv2759680 CNV loss 17122850
esv2764150 CNV gain+loss 21179565
esv3619963 CNV loss 21293372
esv3619964 CNV loss 21293372
esv3619965 CNV gain 21293372
nsv1115160 CNV deletion 24896259
nsv1115161 CNV deletion 24896259
nsv466297 CNV gain 19166990
nsv525510 CNV gain 19592680
nsv613758 CNV gain 21841781
nsv613759 CNV loss 21841781

Additional Variant Information for MIR31HG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR31HG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR31HG Gene

Disorders for MIR31HG Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR31HG Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
lung cancer susceptibility 3
  • lncr3
bladder cancer
  • bladder cancer, somatic
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR31HG

genes like me logo Genes that share disorders with MIR31HG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR31HG Gene

Publications for MIR31HG Gene

  1. Novel long noncoding RNAs (lncRNAs) in myogenesis: a miR-31 overlapping lncRNA transcript controls myoblast differentiation. (PMID: 25512605) Ballarino M … Bozzoni I (Molecular and cellular biology 2015) 2 3 54
  2. Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. (PMID: 24631686) Shi Y … Wang K (Biochemical and biophysical research communications 2014) 2 3 54
  3. miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. (PMID: 22289355) Augoff K … Sossey-Alaoui K (Molecular cancer 2012) 2 3 54
  4. A novel class of mammalian-specific tailless retropseudogenes. (PMID: 15364902) Schmitz J … Brosius J (Genome research 2004) 2 3 54
  5. Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties. (PMID: 30447009) Eide PW … Lothe RA (International journal of cancer 2019) 3 54

Products for MIR31HG Gene

Sources for MIR31HG Gene