microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3198-1 Gene

Subcategory (RNA class) for MIR3198-1 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR3198-1 Gene

  • MicroRNA 3198-1 2 3 5
  • Hsa-Mir-3198-1 2 3
  • MicroRNA 3198 2 3
  • MIR3198-1 2 5
  • Hsa-Mir-3198 3
  • MIMAT0015083 50
  • Hsa-MiR-3198 173
  • Mir-3198-1 3
  • MI0014246 50
  • MIR3198 3

External Ids for MIR3198-1 Gene

Previous HGNC Symbols for MIR3198-1 Gene

  • MIR3198

Previous GeneCards Identifiers for MIR3198-1 Gene

  • GC22M018247

Summaries for MIR3198-1 Gene

Entrez Gene Summary for MIR3198-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3198-1 Gene

MIR3198-1 (MicroRNA 3198-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3198-1 include Retinitis Pigmentosa 41 and Retinitis Pigmentosa 27.

Additional gene information for MIR3198-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3198-1 Gene

Genomics for MIR3198-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3198-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J017763 Enhancer 0.4 ENCODE dbSUPER 600.7 +0.5 490 0.9 HNF4A MIR3198-1 piR-39622-002 BID hsa-miR-5095-329 BCL2L13
GH22J017759 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +3.6 3557 1.5 GATAD2A JUND SP1 CEBPA SOX13 ZBTB20 TCF7 FOXA2 YY1 FOSL1 BID CECR2 BCL2L13 USP18 MIR3198-1 hsa-miR-5095-329
GH22J017751 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +10.9 10858 3.2 HNRNPL CTCF POLR2A RAD21 ZNF316 SMC3 MAFG RXRA ZNF143 KLF1 hsa-miR-5095-329 BID BCL2L13 MIR3198-1
GH22J017761 Enhancer 0.5 dbSUPER 0.7 +2.3 2250 0.6 CEBPA FOXA2 NFIL3 KDM1A FOXA3 MIR3198-1 hsa-miR-5095-329 BID BCL2L13
GH22J017757 Enhancer 0.3 Ensembl dbSUPER 0.4 +5.9 5858 0.4 MIR3198-1 hsa-miR-5095-329 BID BCL2L13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3198-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3198-1 Gene

Genomic Locations for MIR3198-1 Gene
chr22:17,764,180-17,764,259
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chr22:18,246,946-18,247,025
(GRCh37/hg19)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR3198-1 Gene

Genes around MIR3198-1 on UCSC Golden Path with GeneCards custom track
MIR3198-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3198-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3198-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3198-1 Gene

Proteins for MIR3198-1 Gene

Post-translational modifications for MIR3198-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3198-1 Gene

Domains & Families for MIR3198-1 Gene

Gene Families for MIR3198-1 Gene

genes like me logo Genes that share domains with MIR3198-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3198-1 Gene

Function for MIR3198-1 Gene

Phenotypes From GWAS Catalog for MIR3198-1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3198-1 Gene

Localization for MIR3198-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3198-1 Gene

Pathways & Interactions for MIR3198-1 Gene

PathCards logo

SuperPathways for MIR3198-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3198-1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3198-1 Gene

Drugs & Compounds for MIR3198-1 Gene

No Compound Related Data Available

Transcripts for MIR3198-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3198-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A8F7_9606 precursor_RNA 80 5

HGNC: 38236,

RefSeq: NR_036168,

Ensembl: ENST00000583102 (view in UCSC) ,

miRBase: MI0014246,

ENA: LM611056.1:1..80:precursor_RNA,

URS000012568D_9606 miRNA 22 4

RefSeq: NR_036168, NR_039851,

miRBase: MIMAT0015083,

TarBase: hsa-miR-3198,

ENA: FR772780.1:1..22:ncRNA, FR772968.1:1..22:ncRNA, LM381691.1:1..22:ncRNA, LM611056.1:49..70:ncRNA, LM611385.1:49..70:ncRNA,

MIR3198-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3198-1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3198-1 Gene

No ASD Table

Relevant External Links for MIR3198-1 Gene

GeneLoc Exon Structure for
MIR3198-1

Expression for MIR3198-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3198-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR3198-1

genes like me logo Genes that share expression patterns with MIR3198-1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3198-1 Gene

Orthologs for MIR3198-1 Gene

Evolution for MIR3198-1 Gene

ENSEMBL:
Gene Tree for MIR3198-1 (if available)
TreeFam:
Gene Tree for MIR3198-1 (if available)

No data available for Orthologs for MIR3198-1 Gene

Paralogs for MIR3198-1 Gene

No data available for Paralogs for MIR3198-1 Gene

Variants for MIR3198-1 Gene

Additional dbSNP identifiers (rs#s) for MIR3198-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3198-1 Gene

Variant ID Type Subtype PubMed ID
esv3893428 CNV loss 25118596
nsv428385 CNV gain+loss 18775914
nsv526826 CNV gain 19592680
nsv834119 CNV loss 17160897
nsv834120 CNV loss 17160897
nsv979630 CNV duplication 23825009

Additional Variant Information for MIR3198-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3198-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3198-1 Gene

Disorders for MIR3198-1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR3198-1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 41
  • rp41
retinitis pigmentosa 27
  • rp27
usher syndrome, type ig
  • ush1g
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3198-1

genes like me logo Genes that share disorders with MIR3198-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3198-1 Gene

Publications for MIR3198-1 Gene

  1. Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells. (PMID: 31041888) Kanzaki H … Nakamura Y (BMC molecular and cell biology 2019) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  4. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3198-1 Gene

Sources for MIR3198-1 Gene