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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3182 (MicroRNA 3182) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J083512 | Enhancer | 0.6 | Ensembl ENCODE | 0.7 | +5.0 | 4955 | 1.4 | JUND ZXDB FOS FOSL1 | MIR3182 HSALNG0113064 HSBP1 CDH13 | |
GH16J083532 | Enhancer | 0.5 | Ensembl | 0.4 | +24.8 | 24766 | 1 | JUND FOS ZFHX2 ELF1 FOSL2 | MIR3182 HSALNG0113064 HSBP1 CDH13 | |
GH16J083529 | Enhancer | 0.3 | Ensembl ENCODE | 0.4 | +22.2 | 22234 | 1.4 | MIR3182 HSALNG0113064 HSBP1 CDH13 | ||
GH16J083549 | Enhancer | 0.4 | Ensembl | 0.3 | +42.1 | 42054 | 0.8 | POLR2A CTCF MEIS2 | HSALNG0113064 MIR3182 HSBP1 CDH13 | |
GH16J083552 | Enhancer | 0.3 | Ensembl | 0.3 | +44.1 | 44055 | 0.8 | BHLHE40 JUN | HSALNG0113064 MIR3182 HSBP1 CDH13 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075B814_9606 | precursor_RNA | 63 | 5 |
HGNC: 38317, RefSeq: NR_036147, Ensembl: ENST00000580839 (view in UCSC) , miRBase: MI0014224, |
URS00002FAA8C_9606 | miRNA | 17 | 3 |
RefSeq: NR_036147, miRBase: MIMAT0015062, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3051n100 | CNV | gain | 25217958 |
dgv5253n54 | CNV | gain | 21841781 |
esv2761929 | CNV | loss | 21179565 |
nsv1061288 | CNV | gain+loss | 25217958 |
nsv1064977 | CNV | loss | 25217958 |
nsv573371 | CNV | loss | 21841781 |
nsv573397 | CNV | loss | 21841781 |
No disorders were found for MIR3182 Gene.