microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3180-4 Gene

Subcategory (RNA class) for MIR3180-4 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR3180-4 Gene

  • MicroRNA 3180-4 2 3 5
  • Hsa-Mir-3180-4 2 3
  • Hsa-MiR-3180 163 173
  • MIR3180-4 2 5
  • MIMAT0018178 50
  • Mir-3180-4 3
  • MI0016408 50
  • RF02010 168

External Ids for MIR3180-4 Gene

Previous GeneCards Identifiers for MIR3180-4 Gene

  • GC16U901272
  • GC16P015249
  • GC16M015251

Summaries for MIR3180-4 Gene

Entrez Gene Summary for MIR3180-4 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3180-4 Gene

MIR3180-4 (MicroRNA 3180-4) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR3180-4 Gene

Additional gene information for MIR3180-4 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR3180-4 Gene

Genomics for MIR3180-4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3180-4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015153 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 600.7 +1.0 1037 3.6 SP1 GATAD2A PRDM10 BACH1 TARDBP LARP7 ZNF143 ZIC2 RBFOX2 POLR2A ENSG00000257391 Hsa-Mir-3180-P1_5p-002 MIR3180-4 PKD1P6 piR-36538-003 LOC100505915 NPIPA2 RRN3 PDXDC1 NPIPA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3180-4 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3180-4 Gene

Genomic Locations for MIR3180-4 Gene
chr16:15,154,850-15,155,038
(GRCh38/hg38)
Size:
189 bases
Orientation:
Minus strand
chr16:15,248,707-15,248,859
(GRCh37/hg19)
Size:
153 bases
Orientation:
Minus strand

Genomic View for MIR3180-4 Gene

Genes around MIR3180-4 on UCSC Golden Path with GeneCards custom track
MIR3180-4 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3180-4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3180-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3180-4 Gene

Proteins for MIR3180-4 Gene

Post-translational modifications for MIR3180-4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3180-4 Gene

Domains & Families for MIR3180-4 Gene

Gene Families for MIR3180-4 Gene

genes like me logo Genes that share domains with MIR3180-4: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3180-4 Gene

Function for MIR3180-4 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3180-4 Gene

Localization for MIR3180-4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3180-4 Gene

Pathways & Interactions for MIR3180-4 Gene

PathCards logo

SuperPathways for MIR3180-4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3180-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR3180-4: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3180-4 Gene

Drugs & Compounds for MIR3180-4 Gene

No Compound Related Data Available

Transcripts for MIR3180-4 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3180-4 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000759B7E_9606 precursor_RNA 153 5

HGNC: 38920,

RefSeq: NR_037466,

Ensembl: ENST00000582223 (view in UCSC) ,

miRBase: MI0016408,

ENA: LM611242.1:1..153:precursor_RNA,

URS00005FE063_9606 miRNA 19 5

RefSeq: NR_037466, NR_037467,

LncBase: hsa-miR-3180,

miRBase: MIMAT0018178,

TarBase: hsa-miR-3180,

ENA: LM382165.1:1..19:ncRNA, LM611242.1:36..54:ncRNA, LM611243.1:36..54:ncRNA,

URS0000692410_9606 precursor_RNA 114 1

Rfam: RF02010,

URS0000716BF3_9606 precursor_RNA 114 1

Rfam: RF02010,

MIR3180-4 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3180-4 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3180-4 Gene

No ASD Table

Relevant External Links for MIR3180-4 Gene

GeneLoc Exon Structure for
MIR3180-4

Expression for MIR3180-4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3180-4 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3180-4 Gene

This gene is overexpressed in Testis (x4.8).
genes like me logo Genes that share expression patterns with MIR3180-4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3180-4 Gene

Orthologs for MIR3180-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR3180-4 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 49 (a)
OneToMany
Species where no ortholog for MIR3180-4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR3180-4 Gene

ENSEMBL:
Gene Tree for MIR3180-4 (if available)
TreeFam:
Gene Tree for MIR3180-4 (if available)

Paralogs for MIR3180-4 Gene

No data available for Paralogs for MIR3180-4 Gene

Variants for MIR3180-4 Gene

Additional dbSNP identifiers (rs#s) for MIR3180-4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3180-4 Gene

Variant ID Type Subtype PubMed ID
dgv2755n100 CNV gain 25217958
dgv2765n100 CNV gain 25217958
esv21621 CNV loss 19812545
esv2671608 CNV deletion 23128226
esv2758632 CNV gain+loss 17122850
esv2762254 CNV gain+loss 21179565
esv3570354 CNV gain 25503493
esv3638024 CNV loss 21293372
esv3638025 CNV gain 21293372
nsv1036298 CNV gain 25217958
nsv1038955 CNV loss 25217958
nsv1050325 CNV loss 25217958
nsv1053467 CNV loss 25217958
nsv511045 OTHER complex 20534489
nsv7277 OTHER inversion 18451855
nsv9359 CNV gain+loss 18304495
nsv952934 CNV deletion 24416366
nsv977911 CNV duplication 23825009

Additional Variant Information for MIR3180-4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3180-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3180-4 Gene

Disorders for MIR3180-4 Gene

Additional Disease Information for MIR3180-4

No disorders were found for MIR3180-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3180-4 Gene

Publications for MIR3180-4 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3180-4 Gene

Sources for MIR3180-4 Gene