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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3167 (MicroRNA 3167) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3167 include Jacobsen Syndrome.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J126970 | Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +19.0 | 19041 | 1.8 | CTCF RAD21 EGR1 SMC3 ARNT CEBPB KDM1A | ENSG00000255317 HSALNG0088045 KIRREL3 ENSG00000254938 KIRREL3-AS2 MIR3167 lnc-KIRREL3-1 ST3GAL4 | |
GH11J126977 | Enhancer | 0.6 | Ensembl ENCODE dbSUPER | 0.4 | +10.0 | 10041 | 1.4 | SIN3A | KIRREL3 KIRREL3-AS3 ENSG00000255317 HSALNG0088045 MIR3167 lnc-KIRREL3-1 ST3GAL4 | |
GH11J126983 | Enhancer | 0.2 | dbSUPER | 0.7 | +4.1 | 4098 | 1.4 | MIR3167 ENSG00000255317 HSALNG0088045 lnc-KIRREL3-1 KIRREL3 ST3GAL4 | ||
GH11J126974 | Enhancer | 0.2 | dbSUPER | 0.4 | +12.9 | 12926 | 1.3 | ENSG00000254938 KIRREL3-AS2 KIRREL3 KIRREL3-AS3 ENSG00000255317 HSALNG0088045 MIR3167 lnc-KIRREL3-1 ST3GAL4 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A4F3_9606 | precursor_RNA | 85 | 3 |
RefSeq: NR_036126, Ensembl: ENST00000579623 (view in UCSC) , miRBase: MI0014198, |
URS000075AD9F_9606 | miRNA | 22 | 2 |
RefSeq: NR_036126, miRBase: MIMAT0015042, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761719 | CNV | gain | 21179565 |
nsv539 | CNV | insertion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
jacobsen syndrome |
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