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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3162 (MicroRNA 3162) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J059610 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.4 | -18.9 | -18926 | 8.2 | ZNF24 ZBTB40 SP1 SREBF1 FOXA1 SMARCE1 POLR2A CEBPZ USF2 ATF1 | OSBP ENSG00000255008 STX3 MS4A2 ENSG00000255139 LOC101927226 MIR3162 | |
GH11J059601 | Enhancer | 0.6 | ENCODE | 0.4 | -6.8 | -6845 | 0.2 | FOXA1 RAD21 SP1 RXRA FOXA2 JUND ATF3 YY1 ZBTB33 GABPA | ENSG00000255139 MIR3162 OSBP |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001197222 | -- | 59,595,643(-) | A/G | upstream_transcript_variant | |
rs1001231736 | -- | 59,595,914(-) | A/ | upstream_transcript_variant | |
rs1001716572 | -- | 59,596,747(-) | C/G | upstream_transcript_variant | |
rs1002842171 | -- | 59,595,783(-) | A/C | upstream_transcript_variant | |
rs1002935591 | -- | 59,595,493(-) | C/A/T | upstream_transcript_variant |
No disorders were found for MIR3162 Gene.