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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3160-1 (MicroRNA 3160-1) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J046450 | Enhancer | 0.8 | Ensembl ENCODE | 600.7 | -0.2 | -179 | 3.5 | GATAD2A PRDM1 PKNOX1 CEBPA HMBOX1 CTBP1 TEAD1 WT1 SPI1 CEBPB | MIR3160-1 MIR3160-2 CHRM4 ZNF408 ARHGAP1 F2 ATG13 HARBI1 piR-56497-020 AMBRA1 | |
GH11J046455 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | -5.1 | -5111 | 4 | PRDM1 ZIC2 PKNOX1 POLR2A EGR1 CEBPB OSR2 ZFHX2 CEBPG VEZF1 | CHRM4 MDK DGKZ ARHGAP1 ZNF408 F2 ATG13 LRP4 MIR3160-1 piR-56497-020 | |
GH11J046464 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | -13.2 | -13175 | 3.7 | GATAD2A CEBPA CEBPB FOXA2 CEBPG TBP ZNF121 | AMBRA1 MDK DGKZ CHRM4 C11orf49 ATG13 piR-56497-020 MIR3160-1 | |
GH11J046460 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | -10.0 | -10003 | 2.2 | PBX2 SAP130 MAFK DMAP1 TEAD3 ZFP37 | CHRM4 MDK DGKZ ATG13 LRP4 piR-56497-020 MIR3160-1 AMBRA1 | |
GH11J046463 | Enhancer | 0.2 | ENCODE | 0.4 | -11.2 | -11239 | 0.1 | MDK DGKZ CHRM4 ATG13 piR-56497-020 MIR3160-1 AMBRA1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075E12E_9606 | precursor_RNA | 85 | 5 |
HGNC: 38197, RefSeq: NR_036117, Ensembl: ENST00000577972 (view in UCSC) , miRBase: MI0014189, |
URS0000046A2A_9606 | miRNA | 22 | 3 |
miRBase: MIMAT0019212, ENA: FR772751.1:1..22:ncRNA, FR772753.1:1..22:ncRNA, LM611014.1:13..34:ncRNA, LM611015.1:11..32:ncRNA, |
URS0000086029_9606 | miRNA | 22 | 3 |
miRBase: MIMAT0015034, ENA: FR772750.1:1..22:ncRNA, FR772752.1:1..22:ncRNA, LM381657.1:1..22:ncRNA, LM611014.1:54..75:ncRNA, LM611015.1:52..73:ncRNA, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3626183 | CNV | gain | 21293372 |
No disorders were found for MIR3160-1 Gene.