microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3159 Gene

Subcategory (RNA class) for MIR3159 Gene

miRNA

Quality Score for this RNA gene is

15

Aliases for MIR3159 Gene

  • MicroRNA 3159 2 3 5
  • Hsa-Mir-3159 3
  • MIMAT0015033 53
  • Hsa-MiR-3159 179
  • MI0014188 53
  • MIR3159 2

External Ids for MIR3159 Gene

Previous GeneCards Identifiers for MIR3159 Gene

  • GC11U901538
  • GC09P037795
  • GC09P037796
  • GC09P037797
  • GC09P037799
  • GC09P037801
  • GC09P037802
  • GC11P018411

Summaries for MIR3159 Gene

Entrez Gene Summary for MIR3159 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3159 Gene

MIR3159 (MicroRNA 3159) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3159 include Phacogenic Glaucoma.

Additional gene information for MIR3159 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3159 Gene

Genomics for MIR3159 Gene

GeneHancer (GH) Regulatory Elements for MIR3159 Gene

Promoters and enhancers for MIR3159 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018385 Enhancer 0.2 dbSUPER 750.6 -0.9 -910 1.8 MIR3159 LDHC lnc-GTF2H1-2
GH11J018382 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.6 -3.7 -3713 3 SIN3A ZBTB40 POLR2A MIXL1 ETV6 ELF1 L3MBTL2 RAD21 MNT ZKSCAN8 LDHC LDHA LDHAL6A SPTY2D1 HPS5 TSG101 MIR3159 lnc-GTF2H1-2
GH11J018378 Enhancer 0.2 Ensembl 0.4 -9.1 -9086 0.6 LDHA lnc-GTF2H1-2 MIR3159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3159 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR3159 Gene

Genomic Locations for MIR3159 Gene
chr11:18,387,787-18,387,860
(GRCh38/hg38)
Size:
74 bases
Orientation:
Plus strand
chr11:18,409,334-18,409,407
(GRCh37/hg19)
Size:
74 bases
Orientation:
Plus strand

Genomic View for MIR3159 Gene

Genes around MIR3159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3159 Gene

Proteins for MIR3159 Gene

Post-translational modifications for MIR3159 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3159 Gene

Domains & Families for MIR3159 Gene

Gene Families for MIR3159 Gene

HGNC:
genes like me logo Genes that share domains with MIR3159: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3159 Gene

Function for MIR3159 Gene

Phenotypes From GWAS Catalog for MIR3159 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3159 Gene

Localization for MIR3159 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3159 Gene

Pathways & Interactions for MIR3159 Gene

PathCards logo

SuperPathways for MIR3159 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3159 Gene

Drugs & Compounds for MIR3159 Gene

No Compound Related Data Available

Transcripts for MIR3159 Gene

mRNA/cDNA for MIR3159 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) TarBase transcripts :
(3) ENA transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3159 Gene

No ASD Table

Relevant External Links for MIR3159 Gene

GeneLoc Exon Structure for
MIR3159
ECgene alternative splicing isoforms for
MIR3159

Expression for MIR3159 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3159 Gene:

MIR3159
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3159 Gene

Orthologs for MIR3159 Gene

Evolution for MIR3159 Gene

ENSEMBL:
Gene Tree for MIR3159 (if available)
TreeFam:
Gene Tree for MIR3159 (if available)

No data available for Orthologs for MIR3159 Gene

Paralogs for MIR3159 Gene

No data available for Paralogs for MIR3159 Gene

Variants for MIR3159 Gene

Sequence variations from dbSNP and Humsavar for MIR3159 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000638841 -- 18,386,529(+) C/G/T upstream_transcript_variant
rs1000752030 -- 18,386,775(+) G/T upstream_transcript_variant
rs1000752557 -- 18,387,141(+) T/C upstream_transcript_variant
rs1001639386 -- 18,387,995(+) G/C downstream_transcript_variant
rs1001754043 -- 18,388,175(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR3159 Gene

Variant ID Type Subtype PubMed ID
nsv509392 CNV insertion 20534489
nsv510999 OTHER complex 20534489
nsv553633 CNV gain 21841781

Additional Variant Information for MIR3159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3159 Gene

Disorders for MIR3159 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3159 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phacogenic glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3159

genes like me logo Genes that share disorders with MIR3159: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3159 Gene

Publications for MIR3159 Gene

  1. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR3159 Gene

Sources for MIR3159 Gene