microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3149 Gene

Data sources for MIR3149 Gene:

RNA type for MIR3149 Gene

miRNA

Aliases for MIR3149 Gene

External Ids for MIR3149 Gene

Previous GeneCards Identifiers for MIR3149 Gene

  • GC08U901413
  • GC08M077884

Summaries for MIR3149 Gene

Entrez Gene Summary for MIR3149 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3149 Gene

MIR3149 (MicroRNA 3149) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3149 include Chromosome 8Q21.11 Deletion Syndrome and Peters-Plus Syndrome.

Additional gene information for MIR3149 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3149 Gene

Genomics for MIR3149 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3149 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J076966 Enhancer 0.2 Ensembl 250.7 +0.5 549 0.2 HSALNG0066333 MIR3149 HSALNG0066332 PEX2 ZFHX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3149 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3149 Gene

Latest Assembly
chr8:76,966,768-76,966,850
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand

Previous Assembly
chr8:77,879,004-77,879,086
(GRCh37/hg19 by Entrez Gene)
Size:
83 bases
Orientation:
Minus strand

chr8:77,879,004-77,879,086
(GRCh37/hg19 by Ensembl)
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR3149 Gene

Genes around MIR3149 on UCSC Golden Path with GeneCards custom track
MIR3149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3149 Gene

Proteins for MIR3149 Gene

Post-translational modifications for MIR3149 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3149 Gene

Domains & Families for MIR3149 Gene

Gene Families for MIR3149 Gene

HGNC:
genes like me logo Genes that share domains with MIR3149: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3149 Gene

Function for MIR3149 Gene

Phenotypes From GWAS Catalog for MIR3149 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3149 Gene

Localization for MIR3149 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3149 Gene

Pathways & Interactions for MIR3149 Gene

PathCards logo

SuperPathways for MIR3149 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3149 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3149 Gene

Drugs & Compounds for MIR3149 Gene

No Compound Related Data Available

Transcripts for MIR3149 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3149 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000079A8E5_9606 pre_miRNA 83 4

RefSeq: NR_130460,

Ensembl: ENST00000584629 (view in UCSC) ,

miRBase: MI0014176,

ENA: LM611002.1:1..83:precursor_RNA,

URS00005C1F22_9606 miRNA 23 3

RefSeq: NR_130460,

miRBase: MIMAT0015022,

ENA: LM381647.1:1..23:ncRNA, LM611002.1:51..73:ncRNA,

MIR3149 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3149 Gene

No ASD Table

Relevant External Links for MIR3149 Gene

GeneLoc Exon Structure for
MIR3149

No data available for mRNA/cDNA for MIR3149 Gene

Expression for MIR3149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3149 Gene

genes like me logo Genes that share expression patterns with MIR3149: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3149 Gene

Orthologs for MIR3149 Gene

Evolution for MIR3149 Gene

ENSEMBL:
Gene Tree for MIR3149 (if available)
TreeFam:
Gene Tree for MIR3149 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR3149

No data available for Orthologs for MIR3149 Gene

Paralogs for MIR3149 Gene

No data available for Paralogs for MIR3149 Gene

Variants for MIR3149 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3149 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR3149 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3149
Leiden Open Variation Database (LOVD)
MIR3149

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3149 Gene

Disorders for MIR3149 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR3149 Gene - From: COP

Disorder Aliases PubMed IDs
chromosome 8q21.11 deletion syndrome
  • 8q21.11 microdeletion syndrome
peters-plus syndrome
  • ptrpls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3149

genes like me logo Genes that share disorders with MIR3149: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3149 Gene

Publications for MIR3149 Gene

  1. Elevated plasma miRNA-122, -140-3p, -720, -2861, and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells. (PMID: 28961259) Li XD … Gu DF (PloS one 2017) 3
  2. Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome. (PMID: 25933289) Li X … Gu D (PloS one 2015) 3
  3. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3
  4. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3149 Gene

Sources for MIR3149 Gene