microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3127 Gene

Subcategory (RNA class) for MIR3127 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR3127 Gene

  • MicroRNA 3127 2 3 5
  • Hsa-MiR-3127-5p 168 179
  • Hsa-MiR-3127-3p 168 179
  • Hsa-Mir-3127 3
  • MIMAT0014990 53
  • MIMAT0019201 53
  • MI0014144 53
  • Mir-3127 3
  • MIR3127 2

External Ids for MIR3127 Gene

Previous GeneCards Identifiers for MIR3127 Gene

  • GC02U902172
  • GC02P097464

Summaries for MIR3127 Gene

Entrez Gene Summary for MIR3127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3127 Gene

MIR3127 (MicroRNA 3127) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3127 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3127 Gene

Genomics for MIR3127 Gene

GeneHancer (GH) Regulatory Elements for MIR3127 Gene

Promoters and enhancers for MIR3127 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096800 Enhancer 1 ENCODE dbSUPER 0.6 +2.8 2844 0.8 CTCF RBPJ RAD21 MNT BCL6B ELF3 MLLT1 MYC GLIS2 ZIC2 LMAN2L SNRNP200 KANSL3 CNNM4 SEMA4C ANKRD36B ANKRD36 MIR3127 piR-47638
GH02J096786 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -10.2 -10200 3.2 POLR2A CTBP1 ZNF362 ZNF121 MNT ZNF384 MAFK FOSL2 PKNOX1 ZIC2 LMAN2L MIR3127 lnc-LMAN2L-3 CNNM4
GH02J096802 Enhancer 0.7 ENCODE dbSUPER 0.6 +4.2 4172 0.6 EGR1 ZSCAN4 ELF1 FOXA1 HDGF PHF20 EBF1 FOXP1 ZBTB33 MLLT1 LMAN2L CNNM4 MIR3127 piR-47638
GH02J096801 Enhancer 0.7 ENCODE dbSUPER 0.6 +3.6 3642 0.1 CDC5L ZSCAN4 FOXA1 PHF20 ZSCAN26 FOXP1 GLIS1 MLLT1 KANSL3 CNNM4 LMAN2L SNRNP200 ANKRD36 SEMA4C MIR3127 piR-47638
GH02J096772 Enhancer 0.9 ENCODE dbSUPER 0.3 -24.5 -24452 1.9 SREBF1 MNT NKRF MLLT1 CREM ZBED1 IKZF1 CREB1 BACH1 IKZF2 lnc-LMAN2L-3 LMAN2L ENSG00000277701 ENSG00000230606 ANKRD36 ANKRD36B GPAT2P1 CNNM4 MIR3127
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3127 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR3127 Gene

Genomic Locations for MIR3127 Gene
chr2:96,798,278-96,798,353
(GRCh38/hg38)
Size:
76 bases
Orientation:
Plus strand
chr2:97,464,015-97,464,090
(GRCh37/hg19)
Size:
76 bases
Orientation:
Plus strand

Genomic View for MIR3127 Gene

Genes around MIR3127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3127 Gene

Proteins for MIR3127 Gene

Post-translational modifications for MIR3127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3127 Gene

Domains & Families for MIR3127 Gene

Gene Families for MIR3127 Gene

HGNC:
genes like me logo Genes that share domains with MIR3127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3127 Gene

Function for MIR3127 Gene

Phenotypes From GWAS Catalog for MIR3127 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3127 Gene

Localization for MIR3127 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3127 Gene

Pathways & Interactions for MIR3127 Gene

PathCards logo

SuperPathways for MIR3127 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3127 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3127 Gene

Drugs & Compounds for MIR3127 Gene

No Compound Related Data Available

Transcripts for MIR3127 Gene

mRNA/cDNA for MIR3127 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(6) ENA transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :
(2) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3127 Gene

No ASD Table

Relevant External Links for MIR3127 Gene

GeneLoc Exon Structure for
MIR3127
ECgene alternative splicing isoforms for
MIR3127

Expression for MIR3127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR3127 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3127 Gene:

MIR3127
genes like me logo Genes that share expression patterns with MIR3127: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3127 Gene

Orthologs for MIR3127 Gene

Evolution for MIR3127 Gene

ENSEMBL:
Gene Tree for MIR3127 (if available)
TreeFam:
Gene Tree for MIR3127 (if available)

No data available for Orthologs for MIR3127 Gene

Paralogs for MIR3127 Gene

No data available for Paralogs for MIR3127 Gene

Variants for MIR3127 Gene

Sequence variations from dbSNP and Humsavar for MIR3127 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1455470131 pathogenic, Cone-rod dystrophy amelogenesis imperfecta 96,797,521(+) C/T upstream_transcript_variant
rs777167557 uncertain-significance, Cone-rod dystrophy amelogenesis imperfecta 96,797,580(+) G/A/T upstream_transcript_variant
rs886056475 uncertain-significance, Cone-rod dystrophy amelogenesis imperfecta 96,797,083(+) G/A upstream_transcript_variant
rs569907931 uncertain-significance, not provided 96,797,553(+) G/A upstream_transcript_variant
rs1000044748 -- 96,796,462(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR3127 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680
nsv834307 CNV loss 17160897

Additional Variant Information for MIR3127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3127 Gene

Disorders for MIR3127 Gene

Additional Disease Information for MIR3127

No disorders were found for MIR3127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3127 Gene

Publications for MIR3127 Gene

  1. Downregulation of miR-3127-5p promotes epithelial-mesenchymal transition via FZD4 regulation of Wnt/β-catenin signaling in non-small-cell lung cancer. (PMID: 29566281) Yang Y … Gao W (Molecular carcinogenesis 2018) 3 56
  2. Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells. (PMID: 28351032) Bie B … Li Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 56
  3. MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. (PMID: 25849943) Jiang J … Sun C (Oncotarget 2015) 3 56
  4. Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. (PMID: 25284075) Sun Y … Gao W (Scientific reports 2014) 3 56
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 56

Products for MIR3127 Gene

Sources for MIR3127 Gene