microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3127 Gene

Subcategory (RNA class) for MIR3127 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR3127 Gene

  • MicroRNA 3127 2 3 5
  • Hsa-Mir-3127 2 3 178
  • Hsa-MiR-3127-5p 163 173
  • Hsa-MiR-3127-3p 163 173
  • MIR3127 2 5
  • MIMAT0014990 50
  • MIMAT0019201 50
  • MI0014144 50
  • Mir-3127 3

External Ids for MIR3127 Gene

Previous GeneCards Identifiers for MIR3127 Gene

  • GC02U902172
  • GC02P097464

Summaries for MIR3127 Gene

Entrez Gene Summary for MIR3127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3127 Gene

MIR3127 (MicroRNA 3127) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3127 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3127 Gene

Genomics for MIR3127 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3127 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096800 Enhancer 1 ENCODE dbSUPER 0.7 +2.8 2844 0.8 HNRNPL GATAD2A CTCF ZBTB33 TEAD4 NFKBIZ ZNF143 ZIC2 ZSCAN4 RXRB SNRNP200 KANSL3 LMAN2L CNNM4 CNNM3 SEMA4C ANKRD36B STARD7-AS1 ANKRD36 MIR3127
GH02J096786 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -10.2 -10200 3.2 PRDM10 ZNF629 ZNF692 ZIC2 ZNF600 SP2 SP1 CEBPB ZNF316 JUN LMAN2L MIR3127 lnc-LMAN2L-3 CNNM3 CNNM4
GH02J096802 Enhancer 0.8 ENCODE dbSUPER 0.7 +4.2 4172 0.6 ARHGAP35 ZSCAN4 EGR1 FOXA1 ESR1 TSC22D4 POLR2A ELF1 HDGF EBF1 LMAN2L CNNM4 MIR3127 piR-47638 CNNM3
GH02J096801 Enhancer 0.7 ENCODE dbSUPER 0.7 +3.6 3642 0.1 ZSCAN4 FOXA1 TSC22D4 BCLAF1 PHF20 ZSCAN26 GLIS1 FOXP1 MLLT1 CDC5L CNNM4 LMAN2L ANKRD36 SEMA4C MIR3127 piR-47638 CNNM3
GH02J096772 Enhancer 1 ENCODE dbSUPER 0.4 -24.5 -24452 1.9 BACH1 ZSCAN4 IKZF2 TRIM22 YY1 MNT EED RFX1 DPF2 RELB lnc-LMAN2L-3 LMAN2L GPAT2P1 CNNM4 MIR3127 CNNM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3127 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3127 Gene

Genomic Locations for MIR3127 Gene
chr2:96,798,278-96,798,353
(GRCh38/hg38)
Size:
76 bases
Orientation:
Plus strand
chr2:97,464,015-97,464,090
(GRCh37/hg19)
Size:
76 bases
Orientation:
Plus strand

Genomic View for MIR3127 Gene

Genes around MIR3127 on UCSC Golden Path with GeneCards custom track
MIR3127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3127 Gene

Proteins for MIR3127 Gene

Post-translational modifications for MIR3127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3127 Gene

Domains & Families for MIR3127 Gene

Gene Families for MIR3127 Gene

HGNC:
genes like me logo Genes that share domains with MIR3127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3127 Gene

Function for MIR3127 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3127 Gene

Localization for MIR3127 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3127 Gene

Pathways & Interactions for MIR3127 Gene

PathCards logo

SuperPathways for MIR3127 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3127 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3127 Gene

Drugs & Compounds for MIR3127 Gene

No Compound Related Data Available

Transcripts for MIR3127 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3127 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000170D8B_9606 miRNA 23 6

RefSeq: NR_036074,

LncBase: hsa-miR-3127-5p,

miRBase: MIMAT0014990,

MirGeneDB: Hsa-Mir-3127_5p,

TarBase: hsa-miR-3127-5p,

ENA: FR772720.1:1..23:ncRNA, LM381618.1:1..23:ncRNA, LM610974.1:11..33:ncRNA,

URS0000292363_9606 miRNA 22 6

RefSeq: NR_036074,

LncBase: hsa-miR-3127-3p,

miRBase: MIMAT0019201,

MirGeneDB: Hsa-Mir-3127_3p,

TarBase: hsa-miR-3127-3p,

ENA: FR772719.1:1..22:ncRNA, LM610974.1:47..68:ncRNA,

URS000075DB87_9606 precursor_RNA 76 5

HGNC: 38269,

RefSeq: NR_036074,

Ensembl: ENST00000583925 (view in UCSC) ,

miRBase: MI0014144,

ENA: LM610974.1:1..76:precursor_RNA,

URS0000EFC530_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-3127,

MIR3127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3127 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3127 Gene

No ASD Table

Relevant External Links for MIR3127 Gene

GeneLoc Exon Structure for
MIR3127

Expression for MIR3127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3127 Gene

genes like me logo Genes that share expression patterns with MIR3127: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3127 Gene

Orthologs for MIR3127 Gene

Evolution for MIR3127 Gene

ENSEMBL:
Gene Tree for MIR3127 (if available)
TreeFam:
Gene Tree for MIR3127 (if available)

No data available for Orthologs for MIR3127 Gene

Paralogs for MIR3127 Gene

No data available for Paralogs for MIR3127 Gene

Variants for MIR3127 Gene

Additional dbSNP identifiers (rs#s) for MIR3127 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3127 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680
nsv834307 CNV loss 17160897

Additional Variant Information for MIR3127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3127 Gene

Disorders for MIR3127 Gene

Additional Disease Information for MIR3127

No disorders were found for MIR3127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3127 Gene

Publications for MIR3127 Gene

  1. Long noncoding RNA gastric cancer-associated transcript 3 plays oncogenic roles in glioma through sponging miR-3127-5p. (PMID: 30317610) Pan B … Xu L (Journal of cellular physiology 2019) 3
  2. Downregulation of miR-3127-5p promotes epithelial-mesenchymal transition via FZD4 regulation of Wnt/β-catenin signaling in non-small-cell lung cancer. (PMID: 29566281) Yang Y … Gao W (Molecular carcinogenesis 2018) 3
  3. Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells. (PMID: 28351032) Bie B … Li Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3
  4. MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. (PMID: 25849943) Jiang J … Sun C (Oncotarget 2015) 3
  5. Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. (PMID: 25284075) Sun Y … Gao W (Scientific reports 2014) 3

Products for MIR3127 Gene

Sources for MIR3127 Gene