microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3121 Gene

Data sources for MIR3121 Gene:

Subcategory (RNA class) for MIR3121 Gene

miRNA

Aliases for MIR3121 Gene

External Ids for MIR3121 Gene

Previous GeneCards Identifiers for MIR3121 Gene

  • GC01U902994
  • GC01M180407

Summaries for MIR3121 Gene

Entrez Gene Summary for MIR3121 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3121 Gene

MIR3121 (MicroRNA 3121) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3121 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3121 Gene

Genomics for MIR3121 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3121 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J180499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 -63.3 -63335 4.6 CHD2 TBP SP1 ZBTB10 MXD4 SIX5 NR2C1 MNT SMAD5 ETS1 LHX4-AS1 ACBD6 LHX4 CEP350 ENSG00000243155 MIR3121
GH01J180482 Enhancer 0.6 ENCODE 0.3 -44.2 -44231 0.2 DEK CTCF ARNT REST TRIM22 SMC3 RAD21 RFX5 SPI1 FOXK2 ACBD6 LHX4 LHX4-AS1 MIR3121
GH01J180486 Enhancer 0.6 Ensembl 0.3 -48.6 -48610 1.6 FEZF1 ZIC2 PRDM6 HDAC2 KAT2B ZBTB33 ZNF384 PHF21A EGR2 CTCF LHX4 ACBD6 LHX4-AS1 MIR3121
GH01J180495 Enhancer 0.4 Ensembl 0.2 -56.7 -56711 0.2 IKZF1 MZF1 NFIC LHX4 ACBD6 LHX4-AS1 MIR3121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3121 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3121 Gene

Latest Assembly
chr1:180,438,314-180,438,390
(GRCh38/hg38)
Size:
77 bases
Orientation:
Minus strand

Previous Assembly
chr1:180,407,449-180,407,525
(GRCh37/hg19 by Entrez Gene)
Size:
77 bases
Orientation:
Minus strand

chr1:180,407,449-180,407,525
(GRCh37/hg19 by Ensembl)
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR3121 Gene

Genes around MIR3121 on UCSC Golden Path with GeneCards custom track
MIR3121 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3121 Gene

Proteins for MIR3121 Gene

Post-translational modifications for MIR3121 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3121 Gene

Domains & Families for MIR3121 Gene

Gene Families for MIR3121 Gene

HGNC:
genes like me logo Genes that share domains with MIR3121: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3121 Gene

Function for MIR3121 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3121 Gene

Localization for MIR3121 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3121 Gene

Pathways & Interactions for MIR3121 Gene

PathCards logo

SuperPathways for MIR3121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3121 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3121 Gene

Drugs & Compounds for MIR3121 Gene

No Compound Related Data Available

Transcripts for MIR3121 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3121 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D174_9606 precursor_RNA 77 4

RefSeq: NR_036067,

Ensembl: ENST00000579680 (view in UCSC) ,

miRBase: MI0014137,

ENA: LM610967.1:1..77:precursor_RNA,

URS000052EA98_9606 miRNA 22 3

RefSeq: NR_036067,

miRBase: MIMAT0014983,

ENA: FR772714.1:1..22:ncRNA, LM381611.1:1..22:ncRNA, LM610967.1:47..68:ncRNA,

URS000055AE24_9606 miRNA 22 3

RefSeq: NR_036067,

miRBase: MIMAT0019199,

ENA: FR772715.1:1..22:ncRNA, LM610967.1:12..33:ncRNA,

MIR3121 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3121 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3121 Gene

No ASD Table

Relevant External Links for MIR3121 Gene

GeneLoc Exon Structure for
MIR3121

Expression for MIR3121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3121 Gene

genes like me logo Genes that share expression patterns with MIR3121: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3121 Gene

Orthologs for MIR3121 Gene

Evolution for MIR3121 Gene

ENSEMBL:
Gene Tree for MIR3121 (if available)
TreeFam:
Gene Tree for MIR3121 (if available)

No data available for Orthologs for MIR3121 Gene

Paralogs for MIR3121 Gene

No data available for Paralogs for MIR3121 Gene

Variants for MIR3121 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3121 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR3121 Gene

Variant ID Type Subtype PubMed ID
esv2762200 CNV gain 21179565
nsv1003359 CNV gain 25217958
nsv3766 CNV insertion 18451855
nsv527918 CNV gain 19592680

Additional Variant Information for MIR3121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3121

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3121 Gene

Disorders for MIR3121 Gene

Additional Disease Information for MIR3121

No disorders were found for MIR3121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3121 Gene

Publications for MIR3121 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3
  4. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3121 Gene

Sources for MIR3121 Gene