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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3121 (MicroRNA 3121) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J180499 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.2 | -63.3 | -63335 | 4.6 | SP1 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 ZNF512 SIX5 LEF1 KDM1A | LHX4-AS1 ACBD6 LHX4 CEP350 ENSG00000243155 MIR3121 | |
GH01J180482 | Enhancer | 0.6 | ENCODE | 0.3 | -44.2 | -44231 | 0.2 | CTCF DDX20 PRDM1 MTA2 REST RAD21 TRIM22 FOXK2 SMC3 DEK | ACBD6 LHX4 LHX4-AS1 MIR3121 | |
GH01J180486 | Enhancer | 0.6 | Ensembl | 0.3 | -48.5 | -48510 | 1.4 | PHF21A ZIC2 ZFHX2 POLR2A HDAC2 FEZF1 PRDM6 KAT2B ZBTB33 CTCF | LHX4 ACBD6 LHX4-AS1 MIR3121 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075D174_9606 | precursor_RNA | 77 | 5 |
HGNC: 38259, RefSeq: NR_036067, Ensembl: ENST00000579680 (view in UCSC) , miRBase: MI0014137, |
URS000052EA98_9606 | miRNA | 22 | 3 |
RefSeq: NR_036067, miRBase: MIMAT0014983, ENA: FR772714.1:1..22:ncRNA, LM381611.1:1..22:ncRNA, LM610967.1:47..68:ncRNA, |
URS000055AE24_9606 | miRNA | 22 | 3 |
RefSeq: NR_036067, miRBase: MIMAT0019199, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762200 | CNV | gain | 21179565 |
nsv1003359 | CNV | gain | 25217958 |
nsv3766 | CNV | insertion | 18451855 |
nsv527918 | CNV | gain | 19592680 |
No disorders were found for MIR3121 Gene.