microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3120 Gene

Subcategory (RNA class) for MIR3120 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR3120 Gene

  • MicroRNA 3120 2 3 5
  • Hsa-Mir-3120 2 3
  • MIR3120 2 5
  • Hsa-MiR-3120-3p 173
  • MIMAT0019198 50
  • MIMAT0014982 50
  • MI0014136 50
  • Mir-3120 3
  • RF00660 168

External Ids for MIR3120 Gene

Previous GeneCards Identifiers for MIR3120 Gene

  • GC01U902995
  • GC01P143331
  • GC01P172107

Summaries for MIR3120 Gene

Entrez Gene Summary for MIR3120 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3120 Gene

MIR3120 (MicroRNA 3120) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR3120 Gene

Additional gene information for MIR3120 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR3120 Gene

Genomics for MIR3120 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3120 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J172137 Promoter/Enhancer 2.3 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +3.8 3826 9.6 PRDM1 JUND CEBPB USF1 ZFHX2 RCOR1 ZNF366 YY1 JUN GLIS1 DNM3OS RNU6-157P MIR199A2 MIR214 MIR3120 C1orf105 DNM3
GH01J172135 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.2 -2240 1.9 ZNF24 SCRT2 CEBPB JUN EP300 STAT3 MAFK PRDM6 MAFF CTCF RNU6-157P MIR3120 DNM3OS lnc-C1orf105-6 C1orf105 DNM3
GH01J172134 Enhancer 0.7 Ensembl ENCODE 0.7 -4.5 -4488 0.6 PKNOX1 DPF2 BCL11A ARNT ELF1 ATF7 MTA2 TARDBP ZNF24 ZNF687 RNU6-157P MIR3120 lnc-C1orf105-6 C1orf105 DNM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3120 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3120 Gene

Genomic Locations for MIR3120 Gene
chr1:172,138,789-172,138,898
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chr1:172,107,948-172,108,028
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR3120 Gene

Genes around MIR3120 on UCSC Golden Path with GeneCards custom track
MIR3120 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3120 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3120 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3120 Gene

Proteins for MIR3120 Gene

Post-translational modifications for MIR3120 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3120 Gene

Domains & Families for MIR3120 Gene

Gene Families for MIR3120 Gene

HGNC:
genes like me logo Genes that share domains with MIR3120: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3120 Gene

Function for MIR3120 Gene

Phenotypes From GWAS Catalog for MIR3120 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3120 Gene

Localization for MIR3120 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR3120 gene
Compartment Confidence
plasma membrane 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3120 Gene

Pathways & Interactions for MIR3120 Gene

PathCards logo

SuperPathways for MIR3120 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3120 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR3120: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3120 Gene

Drugs & Compounds for MIR3120 Gene

No Compound Related Data Available

Transcripts for MIR3120 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3120 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DDE6_9606 precursor_RNA 81 5

HGNC: 38295,

RefSeq: NR_036066,

Ensembl: ENST00000636555 (view in UCSC) ,

miRBase: MI0014136,

ENA: LM610966.1:1..81:precursor_RNA,

URS0000136174_9606 miRNA 21 4

RefSeq: NR_036066,

miRBase: MIMAT0014982,

TarBase: hsa-miR-3120-3p,

ENA: FR772712.1:1..21:ncRNA, LM381610.1:1..21:ncRNA, LM610966.1:51..71:ncRNA,

URS0000509DB8_9606 miRNA 21 3

RefSeq: NR_036066,

miRBase: MIMAT0019198,

ENA: FR772713.1:1..21:ncRNA, LM610966.1:13..33:ncRNA,

URS0000714B17_9606 precursor_RNA 110 1

Rfam: RF00660,

MIR3120 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3120 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3120 Gene

No ASD Table

Relevant External Links for MIR3120 Gene

GeneLoc Exon Structure for
MIR3120

Expression for MIR3120 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3120 Gene

Orthologs for MIR3120 Gene

Evolution for MIR3120 Gene

ENSEMBL:
Gene Tree for MIR3120 (if available)
TreeFam:
Gene Tree for MIR3120 (if available)

No data available for Orthologs for MIR3120 Gene

Paralogs for MIR3120 Gene

No data available for Paralogs for MIR3120 Gene

Variants for MIR3120 Gene

Additional dbSNP identifiers (rs#s) for MIR3120 Gene

Additional Variant Information for MIR3120 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3120

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3120 Gene

Disorders for MIR3120 Gene

Additional Disease Information for MIR3120

No disorders were found for MIR3120 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3120 Gene

Publications for MIR3120 Gene

  1. MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating. (PMID: 22393045) Scott H … Uney JB (The Journal of biological chemistry 2012) 2 3
  2. miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2. (PMID: 29307822) Hongdan L … Feng L (Biochemical and biophysical research communications 2018) 3
  3. miR‑3120‑5p acts as a diagnostic biomarker in non‑small cell lung cancer and promotes cancer cell proliferation and invasion by targeting KLF4. (PMID: 30221715) Xu H … Wen Q (Molecular medicine reports 2018) 3
  4. LncRNA WTAPP1 Promotes Migration and Angiogenesis of Endothelial Progenitor Cells via MMP1 Through MicroRNA 3120 and Akt/PI3K/Autophagy Pathways. (PMID: 30171660) Li WD … Li XQ (Stem cells (Dayton, Ohio) 2018) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3

Products for MIR3120 Gene

Sources for MIR3120 Gene