microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3117 Gene

Subcategory (RNA class) for MIR3117 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR3117 Gene

  • MicroRNA 3117 2 3 5
  • Hsa-MiR-3117-5p 163 173
  • Hsa-Mir-3117 2 3
  • MIR3117 2 5
  • Hsa-MiR-3117-3p 173
  • MIMAT0019197 50
  • MIMAT0014979 50
  • MI0014130 50
  • Mir-3117 3

External Ids for MIR3117 Gene

Previous GeneCards Identifiers for MIR3117 Gene

  • GC01U903086
  • GC01P067094

Summaries for MIR3117 Gene

Entrez Gene Summary for MIR3117 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3117 Gene

MIR3117 (MicroRNA 3117) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3117 include Peroneal Nerve Paralysis.

Additional gene information for MIR3117 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3117 Gene

Genomics for MIR3117 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3117 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J066623 Enhancer 0.7 Ensembl ENCODE 0.7 -4.0 -4039 2.4 JUND FOS FOSL1 NR2F2 PRDM4 FEZF1 ATF3 PRDM6 JUN POLR2A TCTEX1D1 SGIP1 ENSG00000248458 MIR3117 lnc-INSL5-3 NONHSAG001742.2
GH01J066617 Enhancer 0.6 FANTOM5 ENCODE 0.4 -9.6 -9590 1.7 CEBPB BHLHE40 MAFK SGIP1 ENSG00000248458 TCTEX1D1 MIR3117 lnc-INSL5-3 NONHSAG001742.2
GH01J066649 Enhancer 0.7 Ensembl ENCODE 0.4 +20.8 20761 1.2 DPF2 RELB RUNX3 NR2F1 SPI1 TBX21 ATF7 MTA2 ZNF24 TCTEX1D1 ENSG00000248458 SGIP1 MIR3117
GH01J066598 Enhancer 0.8 Ensembl ENCODE 0.3 -29.0 -29005 2.5 RNF2 ATF7 POLR2A MNT RAD21 JUND CEBPB ATF2 JUN ZBTB21 ENSG00000248458 SGIP1 TCTEX1D1 MIR3117 lnc-INSL5-3 NONHSAG001742.2
GH01J066592 Enhancer 0.7 Ensembl 0.3 -36.3 -36339 0.2 GATAD2A SOX13 RXRB TCF7 ZBTB25 TEAD1 SAP130 SMAD4 BCL6 HOMEZ ENSG00000248458 lnc-INSL5-3 MIR3117 NONHSAG001742.2 SGIP1 TCTEX1D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3117 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3117 Gene

Genomic Locations for MIR3117 Gene
chr1:66,628,440-66,628,517
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr1:67,094,123-67,094,200
(GRCh37/hg19)
Size:
78 bases
Orientation:
Plus strand

Genomic View for MIR3117 Gene

Genes around MIR3117 on UCSC Golden Path with GeneCards custom track
MIR3117 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3117 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3117 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3117 Gene

Proteins for MIR3117 Gene

Post-translational modifications for MIR3117 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3117 Gene

Domains & Families for MIR3117 Gene

Gene Families for MIR3117 Gene

HGNC:
genes like me logo Genes that share domains with MIR3117: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3117 Gene

Function for MIR3117 Gene

Phenotypes From GWAS Catalog for MIR3117 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3117 Gene

Localization for MIR3117 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3117 Gene

Pathways & Interactions for MIR3117 Gene

PathCards logo

SuperPathways for MIR3117 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3117 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3117 Gene

Drugs & Compounds for MIR3117 Gene

No Compound Related Data Available

Transcripts for MIR3117 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3117 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E1C7_9606 precursor_RNA 78 5

HGNC: 38385,

RefSeq: NR_036060,

Ensembl: ENST00000584034 (view in UCSC) ,

miRBase: MI0014130,

ENA: LM610962.1:1..78:precursor_RNA,

URS00004977C5_9606 miRNA 20 5

RefSeq: NR_036060,

LncBase: hsa-miR-3117-5p,

miRBase: MIMAT0019197,

TarBase: hsa-miR-3117-5p,

ENA: FR772711.1:1..20:ncRNA, LM610962.1:13..32:ncRNA,

URS0000507F3E_9606 miRNA 21 4

RefSeq: NR_036060,

miRBase: MIMAT0014979,

TarBase: hsa-miR-3117-3p,

ENA: LM381608.1:1..21:ncRNA, LM610962.1:46..66:ncRNA,

URS00005F035B_9606 miRNA 22 1

ENA: FR772710.1:1..22:ncRNA,

MIR3117 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3117 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3117 Gene

No ASD Table

Relevant External Links for MIR3117 Gene

GeneLoc Exon Structure for
MIR3117

Expression for MIR3117 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3117 Gene

genes like me logo Genes that share expression patterns with MIR3117: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3117 Gene

Orthologs for MIR3117 Gene

Evolution for MIR3117 Gene

ENSEMBL:
Gene Tree for MIR3117 (if available)
TreeFam:
Gene Tree for MIR3117 (if available)

No data available for Orthologs for MIR3117 Gene

Paralogs for MIR3117 Gene

No data available for Paralogs for MIR3117 Gene

Variants for MIR3117 Gene

Additional dbSNP identifiers (rs#s) for MIR3117 Gene

Additional Variant Information for MIR3117 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3117

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3117 Gene

Disorders for MIR3117 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3117 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroneal nerve paralysis
  • peroneal nerve palsy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3117

genes like me logo Genes that share disorders with MIR3117: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3117 Gene

Publications for MIR3117 Gene

  1. miR-3117 regulates hepatocellular carcinoma cell proliferation by targeting PHLPPL. (PMID: 27822662) Cui X … He Y (Molecular and cellular biochemistry 2017) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  4. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3
  5. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3

Products for MIR3117 Gene

Sources for MIR3117 Gene