microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR31 Gene

Subcategory (RNA class) for MIR31 Gene

miRNA

Aliases for MIR31 Gene

External Ids for MIR31 Gene

Previous HGNC Symbols for MIR31 Gene

  • MIRN31

Previous GeneCards Identifiers for MIR31 Gene

  • GC09M021507

Summaries for MIR31 Gene

Entrez Gene Summary for MIR31 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR31 Gene

MIR31 (MicroRNA 31) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR31 include Oral Cancer and Breast Cancer. Among its related pathways are miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma and MicroRNAs in cancer.

Rfam classification for MIR31 Gene

Additional gene information for MIR31 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR31 Gene

Genomics for MIR31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021513 Enhancer 0.2 ENCODE 250.7 -1.5 -1466 0.2 MIR31 ENSG00000264379 IFNE MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021547 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -48.4 -48416 25.9 FEZF1 ZIC2 CEBPB ZNF513 CTCF MAX EP300 ZNF341 ZNF843 RFX5 HSALNG0070366 MIR31 IFNA13 IFNE HSALNG0070367 MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021573 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -71.7 -71724 20.1 ZBTB10 FEZF1 DEK CTCF ZIC2 ZNF610 CEBPB MAX MAFF EP300 MIR31 IFNW1 IFNA1 IFNA6 MIR31HG MIR31HG-002 HSALNG0070367 IFNE ENSG00000264545 MTAP
GH09J021674 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10 -170.4 -170404 16.9 FEZF1 CEBPB ZNF513 FOXA2 MAX EP300 PRDM1 RAD21 ZNF843 STAT3 MIR31 MTAP CDKN2A HSALNG0070378 KHSRPP1 ENSG00000264545 IFNE
GH09J021605 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -93.7 -93699 1 CEBPB EP300 STAT3 ZNF398 PRDM4 ZNF335 HSALNG0070374 MIR31 MIR31HG-002 IFNE ENSG00000264545 MTAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR31 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR31 Gene

Latest Assembly
chr9:21,512,113-21,512,191
(GRCh38/hg38)
Size:
79 bases
Orientation:
Minus strand

Previous Assembly
chr9:21,512,114-21,512,184
(GRCh37/hg19 by Entrez Gene)
Size:
71 bases
Orientation:
Minus strand

chr9:21,512,114-21,512,184
(GRCh37/hg19 by Ensembl)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR31 Gene

Genes around MIR31 on UCSC Golden Path with GeneCards custom track
MIR31 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR31 Gene

Proteins for MIR31 Gene

Post-translational modifications for MIR31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR31 Gene

Domains & Families for MIR31 Gene

Gene Families for MIR31 Gene

HGNC:
genes like me logo Genes that share domains with MIR31: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR31 Gene

Function for MIR31 Gene

Phenotypes From GWAS Catalog for MIR31 Gene

Gene Ontology (GO) - Molecular Function for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 32069773
GO:0005515 protein binding IPI 31012336
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19949084
GO:1990715 mRNA CDS binding IDA 32069773
genes like me logo Genes that share ontologies with MIR31: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR31 Gene

Localization for MIR31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR31 gene
Compartment Confidence
nucleus 1
endosome 1
cytosol 1
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 24558106
GO:0016442 RISC complex IGI 31012336
GO:1990742 microvesicle IDA 26933040
genes like me logo Genes that share ontologies with MIR31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR31 Gene

Pathways & Interactions for MIR31 Gene

genes like me logo Genes that share pathways with MIR31: view

Pathways by source for MIR31 Gene

1 KEGG pathway for MIR31 Gene

Gene Ontology (GO) - Biological Process for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 19949084
GO:0035278 miRNA mediated inhibition of translation IDA 20826792
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process IGI 32069773
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP 26933040
GO:0045766 positive regulation of angiogenesis IDA 28097093
genes like me logo Genes that share ontologies with MIR31: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR31 Gene

Drugs & Compounds for MIR31 Gene

No Compound Related Data Available

Transcripts for MIR31 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR31 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002A291B_9606 miRNA 22 5

RefSeq: NR_029505,

LncBase: hsa-miR-31-3p,

miRBase: MIMAT0004504,

TarBase: hsa-miR-31-3p,

ENA: LM380183.1:1..22:ncRNA, LM608178.1:44..65:ncRNA,

URS00005416E3_9606 miRNA 21 5

RefSeq: NR_029505,

LncBase: hsa-miR-31-5p,

miRBase: MIMAT0000089,

TarBase: hsa-miR-31-5p,

ENA: LM378776.1:1..21:ncRNA, LM608178.1:8..28:ncRNA,

URS0000001EB3_9606 precursor_RNA 71 4

RefSeq: NR_029505,

Ensembl: ENST00000362307 (view in UCSC) ,

miRBase: MI0000089,

ENA: LM608178.1:1..71:precursor_RNA,

URS00006F35A3_9606 precursor_RNA 79 1

Rfam: RF00661,

URS0001BC12AD_9606 pre_miRNA 79 1

Rfam: RF00661,

MIR31 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR31 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR31 Gene

No ASD Table

Relevant External Links for MIR31 Gene

GeneLoc Exon Structure for
MIR31

Expression for MIR31 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR31

Evidence on tissue expression from TISSUES for MIR31 Gene

  • Blood(2.2)
  • Intestine(2.1)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR31 Gene

Orthologs for MIR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-31 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-31 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-31 31
  • 78 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-31 31
  • 72 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir31 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-31 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-31 31
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-31 31
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-31 31
  • 75 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-31 31
  • 49 (a)
OneToOne
Species where no ortholog for MIR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR31 Gene

ENSEMBL:
Gene Tree for MIR31 (if available)
TreeFam:
Gene Tree for MIR31 (if available)

Paralogs for MIR31 Gene

No data available for Paralogs for MIR31 Gene

Variants for MIR31 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR31 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR31 Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2759680 CNV loss 17122850
esv2764150 CNV gain+loss 21179565

Additional Variant Information for MIR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR31

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR31 Gene

Disorders for MIR31 Gene

MalaCards: The human disease database

(85) MalaCards diseases for MIR31 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
oral cancer
  • malignant neoplasm of mouth
breast cancer
  • breast cancer, familial
ovarian cancer
  • ovarian cancer, somatic
psoriasis
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MIR31 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR31

genes like me logo Genes that share disorders with MIR31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR31 Gene

Publications for MIR31 Gene

  1. Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. (PMID: 20179198) Creighton CJ … Anderson ML (Cancer research 2010) 3 74
  2. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. (PMID: 20233326) Liu CJ … Lin SC (Oral diseases 2010) 3 74
  3. MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31. (PMID: 19127597) Veerla S … Höglund M (International journal of cancer 2009) 3 74
  4. Long non-coding RNA CASC2 enhances cisplatin sensitivity in oral squamous cell cancer cells by the miR-31-5p/KANK1 axis. (PMID: 32787433) Wang J … Zhou L (Neoplasma 2020) 3
  5. Abrogation of esophageal carcinoma development in miR-31 knockout rats. (PMID: 32123074) Fong LY … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2020) 3

Products for MIR31 Gene

Sources for MIR31 Gene