microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR31 Gene

Subcategory (RNA class) for MIR31 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR31 Gene

  • MIMAT0000089 50
  • MIMAT0004504 50
  • MI0000089 50
  • RF00661 168
  • MIRN31 3
  • MiR-31 3

External Ids for MIR31 Gene

Previous HGNC Symbols for MIR31 Gene

  • MIRN31

Previous GeneCards Identifiers for MIR31 Gene

  • GC09M021507

Summaries for MIR31 Gene

Entrez Gene Summary for MIR31 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR31 Gene

MIR31 (MicroRNA 31) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR31 include Oral Cancer and Breast Cancer. Among its related pathways are MicroRNAs in cancer and miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma.

Rfam classification for MIR31 Gene

Additional gene information for MIR31 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR31 Gene

Genomics for MIR31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021513 Enhancer 0.3 Ensembl ENCODE 600.7 -1.5 -1501 0.2 MIR31 ENSG00000264379 IFNE MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021512 Enhancer 0.3 Ensembl 600.7 +0.3 290 0.2 POLR2A MIR31 RF00017-7474 IFNE MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021511 Enhancer 0.2 Ensembl 600.7 +1.1 1090 0.2 MIR31 RF00017-7474 IFNE MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021547 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -42.8 -42793 14.6 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 ZSCAN4 PATZ1 REST ZNF501 POLR2A MIR31 IFNE MN309174-656 MIR31HG MIR31HG-002 ENSG00000264545 MTAP
GH09J021573 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -71.7 -71724 20.1 PRDM10 ZNF629 CTCF FOXA1 PRDM1 ZIC2 ZSCAN4 PATZ1 REST ZNF501 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG MIR31HG-002 MN309174-656 IFNE ENSG00000264545
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR31 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR31 Gene

Genomic Locations for MIR31 Gene
chr9:21,512,113-21,512,191
(GRCh38/hg38)
Size:
79 bases
Orientation:
Minus strand
chr9:21,512,114-21,512,184
(GRCh37/hg19)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR31 Gene

Genes around MIR31 on UCSC Golden Path with GeneCards custom track
MIR31 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR31 Gene

Proteins for MIR31 Gene

No data available for DME Specific Peptides for MIR31 Gene

Domains & Families for MIR31 Gene

Gene Families for MIR31 Gene

HGNC:
genes like me logo Genes that share domains with MIR31: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR31 Gene

Function for MIR31 Gene

Phenotypes From GWAS Catalog for MIR31 Gene

Gene Ontology (GO) - Molecular Function for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 31012336
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19949084
genes like me logo Genes that share ontologies with MIR31: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR31 Gene

Localization for MIR31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR31 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 24558106
GO:0016442 RISC complex IGI 31012336
GO:1990742 microvesicle IDA 26933040
genes like me logo Genes that share ontologies with MIR31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR31 Gene

Pathways & Interactions for MIR31 Gene

genes like me logo Genes that share pathways with MIR31: view

Pathways by source for MIR31 Gene

1 KEGG pathway for MIR31 Gene

Gene Ontology (GO) - Biological Process for MIR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 19949084
GO:0035278 miRNA mediated inhibition of translation IDA 20826792
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP 26933040
GO:0045766 positive regulation of angiogenesis IDA 28097093
GO:0050728 negative regulation of inflammatory response IC 19949084
genes like me logo Genes that share ontologies with MIR31: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR31 Gene

Drugs & Compounds for MIR31 Gene

No Compound Related Data Available

Transcripts for MIR31 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR31 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000001EB3_9606 precursor_RNA 71 5

HGNC: 31630,

RefSeq: NR_029505,

Ensembl: ENST00000362307 (view in UCSC) ,

miRBase: MI0000089,

ENA: LM608178.1:1..71:precursor_RNA,

URS00002A291B_9606 miRNA 22 5

RefSeq: NR_029505,

LncBase: hsa-miR-31-3p,

miRBase: MIMAT0004504,

TarBase: hsa-miR-31-3p,

ENA: LM380183.1:1..22:ncRNA, LM608178.1:44..65:ncRNA,

URS00005416E3_9606 miRNA 21 5

RefSeq: NR_029505,

LncBase: hsa-miR-31-5p,

miRBase: MIMAT0000089,

TarBase: hsa-miR-31-5p,

ENA: LM378776.1:1..21:ncRNA, LM608178.1:8..28:ncRNA,

URS00006F35A3_9606 precursor_RNA 79 1

Rfam: RF00661,

URS0000EFD74E_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-31,

MIR31 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR31 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR31 Gene

No ASD Table

Relevant External Links for MIR31 Gene

GeneLoc Exon Structure for
MIR31

Expression for MIR31 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR31

Evidence on tissue expression from TISSUES for MIR31 Gene

  • Blood(2.5)
  • Intestine(2.4)
  • Lymph node(2.2)
  • Skin(2.2)
  • Liver(2.1)
  • Heart(2.1)
  • Muscle(2.1)
  • Saliva(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR31 Gene

Orthologs for MIR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-31 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-31 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-31 31
  • 78 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-31 31
  • 72 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir31 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-31 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-31 31
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-31 31
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-31 31
  • 75 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-31 31
  • 49 (a)
OneToOne
Species where no ortholog for MIR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR31 Gene

ENSEMBL:
Gene Tree for MIR31 (if available)
TreeFam:
Gene Tree for MIR31 (if available)

Paralogs for MIR31 Gene

No data available for Paralogs for MIR31 Gene

Variants for MIR31 Gene

Additional dbSNP identifiers (rs#s) for MIR31 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR31 Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2759680 CNV loss 17122850
esv2764150 CNV gain+loss 21179565

Additional Variant Information for MIR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR31

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR31 Gene

Disorders for MIR31 Gene

MalaCards: The human disease database

(86) MalaCards diseases for MIR31 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • lip and oral cavity carcinoma
breast cancer
  • breast lobular carcinoma
ovarian cancer
  • ovarian cancer, somatic
psoriasis
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MIR31 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIR31

genes like me logo Genes that share disorders with MIR31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR31 Gene

Publications for MIR31 Gene

  1. MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells. (PMID: 31874165) Wang CJ … Ren YS (Life sciences 2020) 3
  2. Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma. (PMID: 31259424) He J … Peng X (International journal of cancer 2020) 3
  3. MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro. (PMID: 31012336) Li M … Li J (Immunological investigations 2019) 3
  4. Down-regulation of microRNA-31-5p inhibits proliferation and invasion of osteosarcoma cells through Wnt/β-catenin signaling pathway by enhancing AXIN1. (PMID: 30844369) Chen X … Li J (Experimental and molecular pathology 2019) 3
  5. MicroRNA‑31 promotes chondrocyte proliferation by targeting C‑X‑C motif chemokine ligand 12. (PMID: 30664157) Dai Y … Zhou X (Molecular medicine reports 2019) 3

Products for MIR31 Gene

Sources for MIR31 Gene