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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR30E Gene
RNA type for MIR30E Gene
miRNA
Aliases for MIR30E Gene
- MIMAT0000692 (miRBase)
- MI0000749 (miRBase)
- MIR30E* (NCBI Entrez Gene)
- MIRN30E (NCBI Entrez Gene)
- Mir-30e (NCBI Entrez Gene)
- RF00131 (Rfam)
- MIR30E (Ensembl)
External Ids for MIR30E Gene
- HGNC: 31629
- NCBI Entrez Gene: 407034
- Ensembl: ENSG00000198974
- OMIM®: 619105
- miRBase: hsa-mir-30e
Previous HGNC Symbols for MIR30E Gene
- MIRN30E
Previous GeneCards Identifiers for MIR30E Gene
- GC01P040993
- GC01P041220
Summaries for MIR30E Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR30E Gene
MIR30E (MicroRNA 30e) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30E include Schizophrenia and Diabetes Mellitus. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.
Rfam classification for MIR30E Gene
-
mir-30 microRNA precursor
Additional gene information for MIR30E Gene
- HGNC (31629)
- NCBI Entrez Gene (407034)
- Ensembl (ENSG00000198974)
- OMIM® (619105)
- Open Targets Platform(ENSG00000198974)
- Alliance of Genome Resources
- Search for MIR30E at DataMed
- Search for MIR30E at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30E Gene
Genomics for MIR30E Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR30E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR30E on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR30E Gene
Latest Assembly
- chr1:40,754,355-40,754,446
- (GRCh38/hg38)
- Size:
- 92 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:41,220,027-41,220,118
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 92 bases
- Orientation:
- Plus strand
Genomic View for MIR30E Gene
Genes around MIR30E on UCSC Golden Path with GeneCards custom track
MIR30E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1p34.2 by HGNC
- 1p34.2 by Entrez Gene
- 1p34.2 by Ensembl
MIR30E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR30E Gene
Proteins for MIR30E Gene
Post-translational modifications for MIR30E Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR30E Gene
Domains & Families for MIR30E Gene
Gene Families for MIR30E Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30E Gene
Function for MIR30E Gene
Phenotypes From GWAS Catalog for MIR30E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25950484 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR30E - Starting at $85 >
- * MIR30E CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR30E - Starting at $45 >
- * MIR30E as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30E Gene
Localization for MIR30E Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30E Gene
Pathways & Interactions for MIR30E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | MicroRNAs in cardiomyocyte hypertrophy | ||
| 3 | miRNA targets in ECM and membrane receptors | ||
| 4 | Parkinsons Disease Pathway | ||
Pathways by source for MIR30E Gene
3 BioSystems pathways for MIR30E Gene
1 KEGG pathway for MIR30E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
| GO:0055118 | negative regulation of cardiac muscle contraction | ISS | -- |
| GO:0140193 | regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process | ISS | -- |
| GO:1903671 | negative regulation of sprouting angiogenesis | IMP | 27780851 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR30E Gene
Transcripts for MIR30E Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30E Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00004DC6A5_9606 | miRNA | 22 | 6 |
RefSeq: NR_029846, LncBase: hsa-miR-30e-3p, miRBase: MIMAT0000693, MirGeneDB: Hsa-Mir-30-P1b_3p, TarBase: hsa-miR-30e-3p, |
| URS00001DE669_9606 | miRNA | 22 | 5 |
RefSeq: NR_029846, LncBase: hsa-miR-30e-5p, miRBase: MIMAT0000692, TarBase: hsa-miR-30e-5p, |
| URS000075C4DE_9606 | pre_miRNA | 92 | 4 |
RefSeq: NR_029846, Ensembl: ENST00000362104 (view in UCSC) , miRBase: MI0000749, |
| URS0000EFBB0B_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-30-P1b, |
| URS00007169CB_9606 | pre_miRNA | 62 | 1 |
Rfam: RF00131, |
MIR30E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR30E Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR30E - Starting at $85 >
- * MIR30E CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR30E - Starting at $45 >
- * MIR30E as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR30E Gene
- GeneLoc Exon Structure for
- MIR30E
Expression for MIR30E Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30E
Primer products for research
-
OriGene qPCR primer pairs for MIR30E
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30E Gene
Orthologs for MIR30E Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-30e 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir30e 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-30e 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | bta-mir-30e 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-30d 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-30e 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-30e 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-30e 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-30d 30 |
|
ManyToMany |
- Species where no ortholog for MIR30E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MIR30E Gene
- ENSEMBL:
- Gene Tree for MIR30E (if available)
- TreeFam:
- Gene Tree for MIR30E (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR30E
Paralogs for MIR30E Gene
No data available for Paralogs for MIR30E Gene
Variants for MIR30E Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3577821 | CNV | loss | 25503493 |
Additional Variant Information for MIR30E Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR30E Gene
Disorders for MIR30E Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia |
|
|
| diabetes mellitus |
|
|
| esophageal cancer |
|
|
| breast cancer |
|
|
| squamous cell carcinoma, head and neck |
|
Search MIR30E in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR30E
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30E Gene
Publications for MIR30E Gene
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40 72
- Prognostic significance of differentially expressed miRNAs in esophageal cancer. (PMID: 20309880) Hu Y … Xu XC (International journal of cancer 2011) 3 72
- A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. (PMID: 20579744) Xu Y … Zhang K (Journal of affective disorders 2010) 3 40
- CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer. (PMID: 32102754) Ma Z … Chen G (Biochemical and biophysical research communications 2020) 3
- Long non-coding RNA DLEU2 promotes the progression of esophageal cancer through miR-30e-5p/E2F7 axis. (PMID: 31884338) Lu T … Cui Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
ExternalLinks
Products for MIR30E Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR30E
- Origene Custom Protein Services for MIR30E
- Browse OriGene Inhibitory RNA Products For MIR30E
- OriGene qPCR primer pairs for MIR30E
- Browse CRISPR knockouts for MIR30E
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR30E
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR30E
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR30E
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR30E
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR30E
Sources for MIR30E Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources