Aliases for MIR30E Gene
Subcategory (RNA class) for MIR30E Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR30E Gene
- HGNC: 31629
- Entrez Gene: 407034
- Ensembl: ENSG00000198974
- miRBase: hsa-mir-30e
Previous HGNC Symbols for MIR30E Gene
- MIRN30E
Previous GeneCards Identifiers for MIR30E Gene
- GC01P040993
- GC01P041220
Summaries for MIR30E Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR30E Gene
MIR30E (MicroRNA 30e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
Additional gene information for MIR30E Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR30E Gene
Genomics for MIR30E Gene
GeneHancer (GH) Regulatory Elements for MIR30E Gene
Promoters and enhancers for MIR30E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR30E on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR30E Gene
Genomic Locations for MIR30E Gene
- chr1:40,754,355-40,754,446
- (GRCh38/hg38)
- Size:
- 92 bases
- Orientation:
- Plus strand
- chr1:41,220,027-41,220,118
- (GRCh37/hg19)
Genomic View for MIR30E Gene
Genes around MIR30E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.2 by Ensembl
- 1p34.2 by Entrez Gene
- 1p34.2 by HGNC
MIR30E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR30E Gene
Proteins for MIR30E Gene
Post-translational modifications for MIR30E Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR30E
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR30E
- Origene Custom Protein Services for MIR30E
- Search GeneTex for Proteins for MIR30E
No data available for DME Specific Peptides for MIR30E Gene
Domains & Families for MIR30E Gene
Gene Families for MIR30E Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30E Gene
Function for MIR30E Gene
Phenotypes From GWAS Catalog for MIR30E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25950484 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR30E
-
- Search ViGene Biosciences for MIR30E
CRISPR Products
- Browse CRISPR knockouts for MIR30E
- Applied Biological Materials CRISPR for MIR30E
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR30E
Inhibitory RNA Products
- Search ViGene Biosciences for MIR30E
Clone Products
- GenScript: Custom all cDNA clones Services for MIR30E
- VectorBuilder custom plasmid, inducible vectors for MIR30E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR30E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR30E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30E Gene
Localization for MIR30E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR30E Gene
Pathways & Interactions for MIR30E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | MicroRNAs in cardiomyocyte hypertrophy | ||
| 3 | miRNA targets in ECM and membrane receptors | ||
| 4 | Parkinsons Disease Pathway | ||
Pathways by source for MIR30E Gene
3 BioSystems pathways for MIR30E Gene
1 KEGG pathway for MIR30E Gene
Interacting Proteins for MIR30E Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
| GO:0035195 | gene silencing by miRNA | IDA | 25950484 |
| GO:1901205 | negative regulation of adrenergic receptor signaling pathway involved in heart process | ISS | -- |
No data available for SIGNOR curated interactions for MIR30E Gene
Transcripts for MIR30E Gene
mRNA/cDNA for MIR30E Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR30E
- Applied Biological Materials CRISPR for MIR30E
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR30E
Inhibitory RNA Products
- Search ViGene Biosciences for MIR30E
Clone Products
- GenScript: Custom all cDNA clones Services for MIR30E
- VectorBuilder custom plasmid, inducible vectors for MIR30E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR30E
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR30E
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR30E Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR30E Gene:
MIR30EPrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30E Gene
Orthologs for MIR30E Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-30e 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir30e 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-30e 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-30e 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-30d 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-30e 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-30e 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-30e 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dre-mir-30d 34 |
|
ManyToMany |
- Species where no ortholog for MIR30E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR30E Gene
No data available for Paralogs for MIR30E Gene
Variants for MIR30E Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001995007 | -- | 40,753,938(+) | T/C | upstream_transcript_variant | |
| rs1002307088 | -- | 40,753,685(+) | C/T | upstream_transcript_variant | |
| rs1005941621 | -- | 40,754,749(+) | C/T | downstream_transcript_variant | |
| rs1007484302 | -- | 40,754,246(+) | C/T | upstream_transcript_variant | |
| rs1009120321 | -- | 40,752,954(+) | T/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3577821 | CNV | loss | 25503493 |
Additional Variant Information for MIR30E Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR30E
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30E Gene
Disorders for MIR30E Gene
Additional Disease Information for MIR30E
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MIR30E Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30E Gene
Publications for MIR30E Gene
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
- A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. (PMID: 20579744) Xu Y … Zhang K (Journal of affective disorders 2010) 3 44 58
- Effect of MicroRNA-30e on the Behavior of Vascular Smooth Muscle Cells via Targeting Ubiquitin-Conjugating Enzyme E2I. (PMID: 28123167) Zong Y … Li D (Circulation journal : official journal of the Japanese Circulation Society 2017) 3 58
- MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway. (PMID: 28288133) Deng L … Sun B (Oncogene 2017) 3 58
- SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. (PMID: 28288641) Liu K … Lan X (Molecular cancer 2017) 3 58
Products for MIR30E Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR30E
- Origene Custom Protein Services for MIR30E
- Browse OriGene Inhibitory RNA Products For MIR30E
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR30E
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR30E
- GenScript: Custom all cDNA clones Services for MIR30E
- GenScript Custom Purified and Recombinant Proteins Services for MIR30E
- GenScript Custom Assay Services for MIR30E
- GenScript Custom overexpressing Cell Line Services for MIR30E
- Browse GenScript CRISPR for MIR30E
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR30E
- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagent
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR30E
- VectorBuilder custom plasmid, inducible vectors for MIR30E
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR30E
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR30E
- Search GeneTex for Proteins for MIR30E
- Search ViGene Biosciences for MIR30E
Sources for MIR30E Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
