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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR30E (MicroRNA 30e) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30E include Schizophrenia and Diabetes Mellitus. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Parkinsons Disease Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25950484 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | MicroRNAs in cardiomyocyte hypertrophy | ||
3 | miRNA targets in ECM and membrane receptors | ||
4 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0055118 | negative regulation of cardiac muscle contraction | ISS | -- |
GO:0140193 | regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process | ISS | -- |
GO:1903671 | negative regulation of sprouting angiogenesis | IMP | 27780851 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00004DC6A5_9606 | miRNA | 22 | 6 |
RefSeq: NR_029846, LncBase: hsa-miR-30e-3p, miRBase: MIMAT0000693, MirGeneDB: Hsa-Mir-30-P1b_3p, TarBase: hsa-miR-30e-3p, |
URS000075C4DE_9606 | precursor_RNA | 92 | 5 |
HGNC: 31629, RefSeq: NR_029846, Ensembl: ENST00000362104 (view in UCSC) , miRBase: MI0000749, |
URS00001DE669_9606 | miRNA | 22 | 5 |
RefSeq: NR_029846, LncBase: hsa-miR-30e-5p, miRBase: MIMAT0000692, TarBase: hsa-miR-30e-5p, |
URS0000EFBB0B_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-30-P1b, |
URS00007169CB_9606 | precursor_RNA | 62 | 1 |
Rfam: RF00131, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-30e 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir30e 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-30e 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-30e 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-30d 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-30e 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-30e 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-30e 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-30d 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3577821 | CNV | loss | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schizophrenia |
|
|
diabetes mellitus |
|
|
esophageal cancer |
|
|
breast cancer |
|
|
squamous cell carcinoma, head and neck |
|