microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30E Gene

Subcategory (RNA class) for MIR30E Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR30E Gene

  • MicroRNA 30e 2 3 5
  • Hsa-MiR-30e-3p 163 173
  • Hsa-MiR-30e-5p 163 173
  • Hsa-Mir-30e 2 3
  • MIR30E 2 5
  • Hsa-Mir-30-P1b 178
  • MIMAT0000693 50
  • MIMAT0000692 50
  • MI0000749 50
  • MIRN30E 3
  • Mir-30e 3
  • RF00131 168

External Ids for MIR30E Gene

Previous HGNC Symbols for MIR30E Gene

  • MIRN30E

Previous GeneCards Identifiers for MIR30E Gene

  • GC01P040993
  • GC01P041220

Summaries for MIR30E Gene

Entrez Gene Summary for MIR30E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30E Gene

MIR30E (MicroRNA 30e) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30E include Schizophrenia and Diabetes Mellitus. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Parkinsons Disease Pathway.

Rfam classification for MIR30E Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30E Gene

Genomics for MIR30E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040752 Enhancer 0.3 Ensembl 600.7 -1.7 -1654 0.6 MLLT1 MIR30E RIMS3 KCNQ4 piR-61945-015 NFYC
GH01J040708 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -43.1 -43117 6.1 SP1 CREB1 GATAD2A TEAD4 PRDM10 ZNF629 REST RFX1 SIX5 LEF1 NFYC EXO5 RLF RIMS3 TRIT1 ENSG00000237899 NFYC-AS1 MIR30E MIR30C1 ENSG00000238287
GH01J040690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -61.7 -61654 4.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 RIMS3 NFYC-AS1 NFYC NONHSAG001168.2 ENSG00000259943 EXO5 TRIT1 ENSG00000237899 ZFP69 SLFNL1
GH01J040801 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 11.1 +48.3 48301 2.8 SP1 IKZF1 KDM1A ZNF24 MTA1 PATZ1 BRD9 HDAC1 SOX6 ZNF341 MIR30C1 MIR30E NFYC KCNQ4 NFYC-AS1 RF00017-177 RN7SL326P lnc-NFYC-1 CITED4
GH01J040948 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 +194.5 194547 1.5 CTCF ZNF512 IKZF1 JUND PRDM1 MTA2 ZIC2 PKNOX1 REST RAD21 piR-38051-004 CITED4 ENSG00000229528 MIR30C1 MIR30E NFYC ENSG00000235358 UBE2V1P8 CTPS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30E on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30E Gene

Genomic Locations for MIR30E Gene
chr1:40,754,355-40,754,446
(GRCh38/hg38)
Size:
92 bases
Orientation:
Plus strand
chr1:41,220,027-41,220,118
(GRCh37/hg19)
Size:
92 bases
Orientation:
Plus strand

Genomic View for MIR30E Gene

Genes around MIR30E on UCSC Golden Path with GeneCards custom track
MIR30E in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR30E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30E Gene

Proteins for MIR30E Gene

Post-translational modifications for MIR30E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30E Gene

Domains & Families for MIR30E Gene

Gene Families for MIR30E Gene

genes like me logo Genes that share domains with MIR30E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30E Gene

Function for MIR30E Gene

Phenotypes From GWAS Catalog for MIR30E Gene

Gene Ontology (GO) - Molecular Function for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25950484
genes like me logo Genes that share ontologies with MIR30E: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30E Gene

Localization for MIR30E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30E gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30E Gene

Pathways & Interactions for MIR30E Gene

genes like me logo Genes that share pathways with MIR30E: view

Pathways by source for MIR30E Gene

Gene Ontology (GO) - Biological Process for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0055118 negative regulation of cardiac muscle contraction ISS --
GO:0140193 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process ISS --
GO:1903671 negative regulation of sprouting angiogenesis IMP 27780851
genes like me logo Genes that share ontologies with MIR30E: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30E Gene

Drugs & Compounds for MIR30E Gene

No Compound Related Data Available

Transcripts for MIR30E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30E Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004DC6A5_9606 miRNA 22 6

RefSeq: NR_029846,

LncBase: hsa-miR-30e-3p,

miRBase: MIMAT0000693,

MirGeneDB: Hsa-Mir-30-P1b_3p,

TarBase: hsa-miR-30e-3p,

ENA: LM379213.1:1..22:ncRNA, LM608676.1:59..80:ncRNA,

URS000075C4DE_9606 precursor_RNA 92 5

HGNC: 31629,

RefSeq: NR_029846,

Ensembl: ENST00000362104 (view in UCSC) ,

miRBase: MI0000749,

ENA: LM608676.1:1..92:precursor_RNA,

URS00001DE669_9606 miRNA 22 5

RefSeq: NR_029846,

LncBase: hsa-miR-30e-5p,

miRBase: MIMAT0000692,

TarBase: hsa-miR-30e-5p,

ENA: LM379212.1:1..22:ncRNA, LM608676.1:17..38:ncRNA,

URS0000EFBB0B_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-30-P1b,

URS00007169CB_9606 precursor_RNA 62 1

Rfam: RF00131,

MIR30E in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30E Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30E Gene

No ASD Table

Relevant External Links for MIR30E Gene

GeneLoc Exon Structure for
MIR30E

Expression for MIR30E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR30E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30E

Evidence on tissue expression from TISSUES for MIR30E Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR30E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30E Gene

Orthologs for MIR30E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30e 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30e 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30e 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30e 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30d 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30e 31
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30e 31
  • 82 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-30e 31
  • 83 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30d 31
  • 42 (a)
ManyToMany
Species where no ortholog for MIR30E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30E Gene

ENSEMBL:
Gene Tree for MIR30E (if available)
TreeFam:
Gene Tree for MIR30E (if available)

Paralogs for MIR30E Gene

No data available for Paralogs for MIR30E Gene

Variants for MIR30E Gene

Additional dbSNP identifiers (rs#s) for MIR30E Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR30E Gene

Variant ID Type Subtype PubMed ID
esv3577821 CNV loss 25503493

Additional Variant Information for MIR30E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR30E Gene

Disorders for MIR30E Gene

MalaCards: The human disease database

(70) MalaCards diseases for MIR30E Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
diabetes mellitus
  • diabetes
esophageal cancer
  • esophageal cancer, somatic
breast cancer
  • breast lobular carcinoma
squamous cell carcinoma, head and neck
  • hnscc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR30E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30E Gene

Publications for MIR30E Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. (PMID: 20579744) Xu Y … Zhang K (Journal of affective disorders 2010) 3 41
  3. miR-30e-5p represses angiogenesis and metastasis by directly targeting AEG-1 in squamous cell carcinoma of the head and neck. (PMID: 31778279) Zhang S … Liu Y (Cancer science 2020) 3
  4. MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. (PMID: 30816508) Wang Z … Zhang X (Molecular medicine reports 2019) 3
  5. MicroRNA-30e inhibits adhesion, migration, invasion and cell cycle progression of prostate cancer cells via inhibition of the activation of the MAPK signaling pathway by downregulating CHRM3. (PMID: 30483762) Zheng XM … Zhang WB (International journal of oncology 2019) 3

Products for MIR30E Gene

Sources for MIR30E Gene