microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30D Gene

Subcategory (RNA class) for MIR30D Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR30D Gene

  • MicroRNA 30d 2 3 5
  • Hsa-MiR-30d-3p 163 173
  • Hsa-MiR-30d-5p 163 173
  • Hsa-Mir-30d 2 3
  • MIR30D 2 5
  • Hsa-Mir-30-P1c 178
  • MIMAT0004551 50
  • MIMAT0000245 50
  • MI0000255 50
  • MIRN30D 3
  • Mir-30d 3
  • RF00131 168

External Ids for MIR30D Gene

Previous HGNC Symbols for MIR30D Gene

  • MIRN30D

Previous GeneCards Identifiers for MIR30D Gene

  • GC08M135889

Summaries for MIR30D Gene

Entrez Gene Summary for MIR30D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30D Gene

MIR30D (MicroRNA 30d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30D include Medulloblastoma and Lung Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Rfam classification for MIR30D Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30D Gene

Genomics for MIR30D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J134805 Enhancer 0.2 Ensembl 600.7 -0.5 -456 0.4 MIR30D ENSG00000254028 LOC102723694 ENSG00000259820 ZFAT KHDRBS3
GH08J134830 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.2 -27.0 -27036 4.4 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 TFE3 ENSG00000259820 ZFAT MIR30D MIR30B NONHSAG051359.2 ENSG00000254028 KHDRBS3
GH08J134754 Enhancer 1 Ensembl ENCODE 11 +50.5 50545 0.8 GATAD2A TFE3 SOX13 RCOR2 FOXA1 RXRB IRF2 SP1 CEBPA FOXK2 lnc-KHDRBS3-5 MIR30B MIR30D ENSG00000272456 ZFAT KHDRBS3
GH08J134734 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.3 +70.2 70174 2 TARDBP FOXA1 PKNOX1 SOX6 CTBP1 ESRRA ZNF217 MBD2 ESR1 GATA3 MIR30B MIR30D ENSG00000272456 ZFAT lnc-KHDRBS3-5 KHDRBS3
GH08J134777 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.1 +25.3 25344 5.2 JUND RFX1 FOS JUN FOSL1 BCL6 TAL1 ATF3 SMARCE1 FOSL2 MIR30B MIR30D lnc-KHDRBS3-16 piR-44110-086 ENSG00000259820 ZFAT KHDRBS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30D Gene

Genomic Locations for MIR30D Gene
chr8:134,804,876-134,804,945
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chr8:135,817,119-135,817,188
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR30D Gene

Genes around MIR30D on UCSC Golden Path with GeneCards custom track
MIR30D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR30D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30D Gene

Proteins for MIR30D Gene

Post-translational modifications for MIR30D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30D Gene

Domains & Families for MIR30D Gene

Gene Families for MIR30D Gene

genes like me logo Genes that share domains with MIR30D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30D Gene

Function for MIR30D Gene

Phenotypes From GWAS Catalog for MIR30D Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30D Gene

Localization for MIR30D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30D gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR30D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30D Gene

Pathways & Interactions for MIR30D Gene

genes like me logo Genes that share pathways with MIR30D: view

Pathways by source for MIR30D Gene

1 BioSystems pathway for MIR30D Gene
1 KEGG pathway for MIR30D Gene

Gene Ontology (GO) - Biological Process for MIR30D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR30D: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30D Gene

Drugs & Compounds for MIR30D Gene

No Compound Related Data Available

Transcripts for MIR30D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30D Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004B2A47_9606 miRNA 22 6

RefSeq: NR_029599,

LncBase: hsa-miR-30d-3p,

miRBase: MIMAT0004551,

MirGeneDB: Hsa-Mir-30-P1c_3p,

TarBase: hsa-miR-30d-3p,

ENA: LM380230.1:1..22:ncRNA, LM608332.1:46..67:ncRNA,

URS000036BDAF_9606 precursor_RNA 70 5

HGNC: 31628,

RefSeq: NR_029599,

Ensembl: ENST00000362283 (view in UCSC) ,

miRBase: MI0000255,

ENA: LM608332.1:1..70:precursor_RNA,

URS000005CF5F_9606 miRNA 22 5

RefSeq: NR_029599,

LncBase: hsa-miR-30d-5p,

miRBase: MIMAT0000245,

TarBase: hsa-miR-30d-5p,

ENA: LM378887.1:1..22:ncRNA, LM608332.1:6..27:ncRNA,

URS0000EFBEE4_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-30-P1c,

URS000066AE98_9606 precursor_RNA 60 1

Rfam: RF00131,

MIR30D in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30D Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30D Gene

No ASD Table

Relevant External Links for MIR30D Gene

GeneLoc Exon Structure for
MIR30D

Expression for MIR30D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30D

Evidence on tissue expression from TISSUES for MIR30D Gene

  • Blood(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30D Gene

Orthologs for MIR30D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30d 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30d 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30d 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30d 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30d 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30d 31
  • 89 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-30d 31
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30a 31
  • 67 (a)
OneToOne
Species where no ortholog for MIR30D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30D Gene

ENSEMBL:
Gene Tree for MIR30D (if available)
TreeFam:
Gene Tree for MIR30D (if available)

Paralogs for MIR30D Gene

No data available for Paralogs for MIR30D Gene

Variants for MIR30D Gene

Additional dbSNP identifiers (rs#s) for MIR30D Gene

Additional Variant Information for MIR30D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30D Gene

Disorders for MIR30D Gene

MalaCards: The human disease database

(19) MalaCards diseases for MIR30D Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30D

genes like me logo Genes that share disorders with MIR30D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30D Gene

Publications for MIR30D Gene

  1. Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. (PMID: 30804330) Zhuang H … Li Y (Cell death & disease 2019) 3
  2. Serum miR-30d as a novel biomarker for multiple myeloma and its antitumor role in U266 cells through the targeting of the MTDH/PI3K/Akt signaling pathway. (PMID: 30132507) Zhu B … Cong H (International journal of oncology 2018) 3
  3. Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer. (PMID: 29797600) Liang YK … Zhong WD (Journal of cellular biochemistry 2018) 3
  4. DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p. (PMID: 30266402) Wu ZH … Sun Q (Biochemical and biophysical research communications 2018) 3
  5. MicroRNA-30d/JAG1 axis modulates pulmonary fibrosis through Notch signaling pathway. (PMID: 30029934) Zhao S … Fan F (Pathology, research and practice 2018) 3

Products for MIR30D Gene

Sources for MIR30D Gene