microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30D Gene

RNA type for MIR30D Gene

miRNA

Aliases for MIR30D Gene

External Ids for MIR30D Gene

Previous HGNC Symbols for MIR30D Gene

  • MIRN30D

Previous GeneCards Identifiers for MIR30D Gene

  • GC08M135889

Summaries for MIR30D Gene

Entrez Gene Summary for MIR30D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30D Gene

MIR30D (MicroRNA 30d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30D include Medulloblastoma and Lung Cancer. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.

Rfam classification for MIR30D Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30D Gene

Genomics for MIR30D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J134804 Promoter 0.3 Ensembl 250.7 +0.0 45 0.2 MIR30D lnc-KHDRBS3-15 LOC102723694 ENSG00000259820 ZFAT KHDRBS3
GH08J134805 Enhancer 0.2 Ensembl 250.7 -0.4 -356 0.2 MIR30D ENSG00000254028 LOC102723694 ENSG00000259820 ZFAT KHDRBS3
GH08J134830 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.2 -27.1 -27136 4.2 SP1 NCOR1 ZNF600 MYC IKZF1 ATF2 BRCA1 NFIC POLR2A ZBTB10 ENSG00000259820 HSALNG0068822 HSALNG0068828 ZFAT MIR30D MIR30B NONHSAG051359.2 ENSG00000254028 KHDRBS3
GH08J134754 Enhancer 1 Ensembl ENCODE 11 +50.5 50545 0.8 CEBPA CHD4 YY1 FOXA1 ZNF217 THAP11 FOXA2 CTBP1 SMAD4 RXRA lnc-KHDRBS3-5 MIR30B MIR30D ENSG00000272456 ZFAT KHDRBS3
GH08J134734 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.3 +70.3 70271 2.1 BHLHE40 FEZF1 SIX4 SIN3A ZNF217 MBD2 CTBP1 GATA3 PKNOX1 FOXA1 MIR30B MIR30D ENSG00000272456 lnc-KHDRBS3-5 ZFAT KHDRBS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30D Gene

Latest Assembly
chr8:134,804,876-134,804,945
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand

Previous Assembly
chr8:135,817,119-135,817,188
(GRCh37/hg19 by Entrez Gene)
Size:
70 bases
Orientation:
Minus strand

chr8:135,817,119-135,817,188
(GRCh37/hg19 by Ensembl)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR30D Gene

Genes around MIR30D on UCSC Golden Path with GeneCards custom track
MIR30D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR30D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30D Gene

Proteins for MIR30D Gene

Post-translational modifications for MIR30D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30D Gene

Domains & Families for MIR30D Gene

Gene Families for MIR30D Gene

genes like me logo Genes that share domains with MIR30D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30D Gene

Function for MIR30D Gene

Phenotypes From GWAS Catalog for MIR30D Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30D Gene

Localization for MIR30D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30D gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR30D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0070062 extracellular exosome IDA 31926946
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30D Gene

Pathways & Interactions for MIR30D Gene

genes like me logo Genes that share pathways with MIR30D: view

Pathways by source for MIR30D Gene

1 BioSystems pathway for MIR30D Gene
1 KEGG pathway for MIR30D Gene

Gene Ontology (GO) - Biological Process for MIR30D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR30D: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30D Gene

Drugs & Compounds for MIR30D Gene

No Compound Related Data Available

Transcripts for MIR30D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30D Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004B2A47_9606 miRNA 22 6

RefSeq: NR_029599,

LncBase: hsa-miR-30d-3p,

miRBase: MIMAT0004551,

MirGeneDB: Hsa-Mir-30-P1c_3p,

TarBase: hsa-miR-30d-3p,

ENA: LM380230.1:1..22:ncRNA, LM608332.1:46..67:ncRNA,

URS000005CF5F_9606 miRNA 22 5

RefSeq: NR_029599,

LncBase: hsa-miR-30d-5p,

miRBase: MIMAT0000245,

TarBase: hsa-miR-30d-5p,

ENA: LM378887.1:1..22:ncRNA, LM608332.1:6..27:ncRNA,

URS000036BDAF_9606 pre_miRNA 70 4

RefSeq: NR_029599,

Ensembl: ENST00000362283 (view in UCSC) ,

miRBase: MI0000255,

ENA: LM608332.1:1..70:precursor_RNA,

URS0000EFBEE4_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-30-P1c,

URS000066AE98_9606 pre_miRNA 60 1

Rfam: RF00131,

MIR30D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30D Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30D Gene

No ASD Table

Relevant External Links for MIR30D Gene

GeneLoc Exon Structure for
MIR30D

Expression for MIR30D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30D

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30D Gene

Orthologs for MIR30D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30d 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30d 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30d 30
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30d 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30d 30
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30d 30
  • 89 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-30d 30
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30a 30
  • 67 (a)
OneToOne
Species where no ortholog for MIR30D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30D Gene

ENSEMBL:
Gene Tree for MIR30D (if available)
TreeFam:
Gene Tree for MIR30D (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR30D

Paralogs for MIR30D Gene

No data available for Paralogs for MIR30D Gene

Variants for MIR30D Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR30D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR30D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30D
Leiden Open Variation Database (LOVD)
MIR30D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30D Gene

Disorders for MIR30D Gene

MalaCards: The human disease database

(18) MalaCards diseases for MIR30D Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
medulloblastoma
  • mdb
lung cancer
  • lung cancer, susceptibility to
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
primary biliary cholangitis
  • biliary liver cirrhosis
muscular dystrophy, duchenne type
  • dmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30D

genes like me logo Genes that share disorders with MIR30D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30D Gene

Publications for MIR30D Gene

  1. Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. (PMID: 17989717) Marton S … Cayota A (Leukemia 2008) 3 72
  2. [microRNA-30d can inhibit the proliferation, migration and invasion of human mesothelial cell MSTO-211H]. (PMID: 33691362) Yuan XY … Zhu LJ (Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2021) 3
  3. A novel long noncoding RNA, LOC440173, promotes the progression of esophageal squamous cell carcinoma by modulating the miR-30d-5p/HDAC9 axis and the epithelial-mesenchymal transition. (PMID: 33079409) Wang G … Dong Z (Molecular carcinogenesis 2020) 3
  4. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  5. Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome. (PMID: 32770028) Capaci V … Del Sal G (Nature communications 2020) 3

Products for MIR30D Gene

Sources for MIR30D Gene