microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30C2 Gene

Subcategory (RNA class) for MIR30C2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR30C2 Gene

  • MicroRNA 30c-2 2 3 5
  • Hsa-MiR-30c-2-3p 166 177
  • Hsa-MiR-30c-5p 166 177
  • Hsa-Mir-30c-2 3
  • MIMAT0000244 51
  • MIMAT0004550 51
  • Mir-30c-2 3
  • MI0000254 51
  • MIRN30C2 3
  • MiR-30c 3
  • MIR30C2 2
  • RF00131 172

External Ids for MIR30C2 Gene

Previous HGNC Symbols for MIR30C2 Gene

  • MIRN30C2

Previous GeneCards Identifiers for MIR30C2 Gene

  • GC06M072146
  • GC06M072086
  • GC06M071380
  • GC06M071381

Summaries for MIR30C2 Gene

Entrez Gene Summary for MIR30C2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30C2 Gene

MIR30C2 (MicroRNA 30c-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Rfam classification for MIR30C2 Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30C2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30C2 Gene

Genomics for MIR30C2 Gene

GeneHancer (GH) Regulatory Elements for MIR30C2 Gene

Promoters and enhancers for MIR30C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J071375 Enhancer 0.5 Ensembl ENCODE 500.7 +0.8 837 1.9 FOXA1 SOX13 MIR30C2 lnc-OGFRL1-6 ENSG00000269966 LINC00472
GH06J071377 Enhancer 0.3 dbSUPER 500.7 -1.1 -1136 1.7 ZNF24 MIR30C2 RIMS1 lnc-OGFRL1-7 ENSG00000269966 LINC00472
GH06J071400 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 -30.3 -30314 13.7 ZBTB40 ZSCAN5C TCF12 TEAD4 ZIC2 TRIM28 EP300 TEAD1 ZNF341 OSR2 lnc-OGFRL1-8 MIR30C2 ENSG00000230597 ENSG00000232295 RIMS1 LINC00472 AF480569 MIR30A ENSG00000269966
GH06J071513 Enhancer 0.2 Ensembl 11.4 -137.2 -137170 0.8 MIR30A MIR30C2 RIMS1 lnc-OGFRL1-12 ENSG00000285963
GH06J071365 Enhancer 0.9 Ensembl ENCODE 0.4 +10.1 10130 4.2 FOS EP300 TRIM28 RELA CUX1 BCL11A FOSL2 MEF2B JUND NBN OGFRL1 MIR30A lnc-OGFRL1-6 MIR30C2 ENSG00000269966 LINC00472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30C2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR30C2 Gene

Genomic Locations for MIR30C2 Gene
chr6:71,376,960-71,377,031
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chr6:72,086,663-72,086,734
(GRCh37/hg19)
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR30C2 Gene

Genes around MIR30C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30C2 Gene

Proteins for MIR30C2 Gene

Post-translational modifications for MIR30C2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30C2 Gene

Domains & Families for MIR30C2 Gene

Gene Families for MIR30C2 Gene

genes like me logo Genes that share domains with MIR30C2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30C2 Gene

Function for MIR30C2 Gene

Gene Ontology (GO) - Molecular Function for MIR30C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding IDA 28062296
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23749231
genes like me logo Genes that share ontologies with MIR30C2: view

Animal Model Products

CRISPR Products

miRNA for MIR30C2 Gene

miRTarBase miRNAs that target MIR30C2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR30C2 Gene

Localization for MIR30C2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30C2 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR30C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 28062296
genes like me logo Genes that share ontologies with MIR30C2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30C2 Gene

Pathways & Interactions for MIR30C2 Gene

genes like me logo Genes that share pathways with MIR30C2: view

Pathways by source for MIR30C2 Gene

2 BioSystems pathways for MIR30C2 Gene
1 KEGG pathway for MIR30C2 Gene
;

Gene Ontology (GO) - Biological Process for MIR30C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 25732226
GO:0010629 negative regulation of gene expression IDA 25732226
GO:0010868 negative regulation of triglyceride biosynthetic process IDA 23749231
GO:0030336 negative regulation of cell migration IDA 25732226
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 25732226
genes like me logo Genes that share ontologies with MIR30C2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30C2 Gene

Drugs & Compounds for MIR30C2 Gene

No Compound Related Data Available

Transcripts for MIR30C2 Gene

mRNA/cDNA for MIR30C2 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30C2 Gene

No ASD Table

Relevant External Links for MIR30C2 Gene

GeneLoc Exon Structure for
MIR30C2

Expression for MIR30C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR30C2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30C2

genes like me logo Genes that share expression patterns with MIR30C2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30C2 Gene

Orthologs for MIR30C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30c-2 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30c-2 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30c-2 31
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30f 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30c-1 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30c-2 31
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30c-2 31
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30c 31
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30c 31
  • 63 (a)
OneToMany
Species where no ortholog for MIR30C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30C2 Gene

ENSEMBL:
Gene Tree for MIR30C2 (if available)
TreeFam:
Gene Tree for MIR30C2 (if available)

Paralogs for MIR30C2 Gene

No data available for Paralogs for MIR30C2 Gene

Variants for MIR30C2 Gene

Additional dbSNP identifiers (rs#s) for MIR30C2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR30C2 Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER inversion 21111241
nsv603640 CNV gain 21841781
nsv7382 OTHER inversion 18451855

Additional Variant Information for MIR30C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR30C2 Gene

Disorders for MIR30C2 Gene

Additional Disease Information for MIR30C2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR30C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30C2 Gene

Publications for MIR30C2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41 54
  2. Upregulated LncRNA-CCAT1 promotes hepatocellular carcinoma progression by functioning as miR-30c-2-3p sponge. (PMID: 30773676) Zhang J … Xu L (Cell biochemistry and function 2019) 3 54
  3. miR-30c Impedes Glioblastoma Cell Proliferation and Migration by Targeting SOX9. (PMID: 29495977) Liu S … Zhuang S (Oncology research 2019) 3 54
  4. Biological function of microRNA-30c/SOX9 in pediatric osteosarcoma cell growth and metastasis. (PMID: 29364496) Zhang XD … Kong WQ (European review for medical and pharmacological sciences 2018) 3 54
  5. Serum miR-30c Level Predicted Cardiotoxicity in Non-small Cell Lung Cancer Patients Treated with Bevacizumab. (PMID: 29737469) Zhou F … Zhang X (Cardiovascular toxicology 2018) 3 54

Products for MIR30C2 Gene

Sources for MIR30C2 Gene