microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30C1 Gene

Subcategory (RNA class) for MIR30C1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR30C1 Gene

  • MicroRNA 30c-1 2 3 5
  • Hsa-MiR-30c-1-3p 163 173
  • Hsa-MiR-30c-5p 163 173
  • Hsa-Mir-30c-1 2 3
  • MIR30C1 2 5
  • Hsa-Mir-30-P2b 178
  • MIMAT0000244 50
  • MIMAT0004674 50
  • Mir-30c-1 3
  • MI0000736 50
  • MIRN30C1 3
  • MiR-30c 3
  • RF00131 168

External Ids for MIR30C1 Gene

Previous HGNC Symbols for MIR30C1 Gene

  • MIRN30C1

Previous GeneCards Identifiers for MIR30C1 Gene

  • GC01P040996
  • GC01P041222

Summaries for MIR30C1 Gene

Entrez Gene Summary for MIR30C1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30C1 Gene

MIR30C1 (MicroRNA 30c-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30C1 include Respiratory System Benign Neoplasm and Hepatocellular Carcinoma. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Rfam classification for MIR30C1 Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30C1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30C1 Gene

Genomics for MIR30C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30C1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30C1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30C1 Gene

Genomic Locations for MIR30C1 Gene
chr1:40,757,284-40,757,372
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr1:41,222,956-41,223,044
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR30C1 Gene

Genes around MIR30C1 on UCSC Golden Path with GeneCards custom track
MIR30C1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR30C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30C1 Gene

Proteins for MIR30C1 Gene

Post-translational modifications for MIR30C1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30C1 Gene

Domains & Families for MIR30C1 Gene

Gene Families for MIR30C1 Gene

genes like me logo Genes that share domains with MIR30C1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30C1 Gene

Function for MIR30C1 Gene

Phenotypes From GWAS Catalog for MIR30C1 Gene

Gene Ontology (GO) - Molecular Function for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding IDA 28062296
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23749231
genes like me logo Genes that share ontologies with MIR30C1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30C1 Gene

Localization for MIR30C1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30C1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 28062296
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30C1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30C1 Gene

Pathways & Interactions for MIR30C1 Gene

genes like me logo Genes that share pathways with MIR30C1: view

Pathways by source for MIR30C1 Gene

1 BioSystems pathway for MIR30C1 Gene
1 KEGG pathway for MIR30C1 Gene

Gene Ontology (GO) - Biological Process for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010868 negative regulation of triglyceride biosynthetic process IDA 23749231
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042632 cholesterol homeostasis ISS 27365390
GO:0045541 negative regulation of cholesterol biosynthetic process ISS 27365390
GO:0045717 negative regulation of fatty acid biosynthetic process IDA 23749231
genes like me logo Genes that share ontologies with MIR30C1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30C1 Gene

Drugs & Compounds for MIR30C1 Gene

No Compound Related Data Available

Transcripts for MIR30C1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30C1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000237FB8_9606 miRNA 22 6

RefSeq: NR_029833,

LncBase: hsa-miR-30c-1-3p,

miRBase: MIMAT0004674,

MirGeneDB: Hsa-Mir-30-P2b_3p,

TarBase: hsa-miR-30c-1-3p,

ENA: LM380338.1:1..22:ncRNA, LM608663.1:56..77:ncRNA,

URS000075D43C_9606 precursor_RNA 89 5

HGNC: 31626,

RefSeq: NR_029833,

Ensembl: ENST00000385227 (view in UCSC) ,

miRBase: MI0000736,

ENA: LM608663.1:1..89:precursor_RNA,

URS000019907A_9606 miRNA 23 5

RefSeq: NR_029598, NR_029833,

LncBase: hsa-miR-30c-5p,

miRBase: MIMAT0000244,

TarBase: hsa-miR-30c-5p,

ENA: HB859653.1:1..23:misc_RNA, LM378886.1:1..23:ncRNA, LM608331.1:7..29:ncRNA, LM608663.1:17..39:ncRNA,

URS0000EFE9B8_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-30-P2b,

URS00006D4A6F_9606 precursor_RNA 59 1

Rfam: RF00131,

MIR30C1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30C1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30C1 Gene

No ASD Table

Relevant External Links for MIR30C1 Gene

GeneLoc Exon Structure for
MIR30C1

Expression for MIR30C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR30C1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30C1

genes like me logo Genes that share expression patterns with MIR30C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30C1 Gene

Orthologs for MIR30C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30C1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30c-1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30c-1 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30c-1 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30c-2 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30c 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30c-1 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30c-1 31
  • 92 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 85 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30c 31
  • 70 (a)
OneToMany
Species where no ortholog for MIR30C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30C1 Gene

ENSEMBL:
Gene Tree for MIR30C1 (if available)
TreeFam:
Gene Tree for MIR30C1 (if available)

Paralogs for MIR30C1 Gene

No data available for Paralogs for MIR30C1 Gene

Variants for MIR30C1 Gene

Additional dbSNP identifiers (rs#s) for MIR30C1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR30C1 Gene

Variant ID Type Subtype PubMed ID
esv3577821 CNV loss 25503493

Additional Variant Information for MIR30C1 Gene

Human Gene Mutation Database (HGMD)
MIR30C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR30C1 Gene

Disorders for MIR30C1 Gene

MalaCards: The human disease database

(32) MalaCards diseases for MIR30C1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
hepatocellular carcinoma
  • hcc
pediatric osteosarcoma
  • childhood osteosarcoma
lung adenoma
  • adenoma of lung
bronchiolo-alveolar adenocarcinoma
  • bronchioalveolar lung carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30C1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR30C1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30C1 Gene

Publications for MIR30C1 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  5. Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers. (PMID: 31923920) Kwak YH … Yoo JH (PloS one 2020) 3

Products for MIR30C1 Gene

Sources for MIR30C1 Gene