microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30B Gene

Subcategory (RNA class) for MIR30B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR30B Gene

  • MicroRNA 30b 2 3 5
  • Hsa-MiR-30b-5p 163 173
  • Hsa-MiR-30b-3p 163 173
  • Hsa-Mir-30b 2 3
  • MIR30B 2 5
  • Hsa-Mir-30-P2c 178
  • MIMAT0000420 50
  • MIMAT0004589 50
  • MI0000441 50
  • MIRN30B 3
  • Mir-30b 3
  • RF00131 168

External Ids for MIR30B Gene

Previous HGNC Symbols for MIR30B Gene

  • MIRN30B

Previous GeneCards Identifiers for MIR30B Gene

  • GC08M135884

Summaries for MIR30B Gene

Entrez Gene Summary for MIR30B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30B Gene

MIR30B (MicroRNA 30b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30B include Medulloblastoma and Lymphoma, Hodgkin, Classic. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Rfam classification for MIR30B Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30B Gene

Genomics for MIR30B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J134799 Enhancer 1 Ensembl ENCODE 600.7 -1.8 -1794 5.2 CREB1 GATAD2A TFE3 RCOR2 JUND FOXA1 RXRB SP1 CEBPA MNT MIR30B lnc-KHDRBS3-15 ENSG00000259820 MIR30D LOC102723694 lnc-KHDRBS3-16 ZFAT KHDRBS3
GH08J134830 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.1 -31.4 -31374 4.4 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 TFE3 ENSG00000259820 ZFAT MIR30D MIR30B NONHSAG051359.2 ENSG00000254028 KHDRBS3
GH08J134711 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.9 +87.4 87419 3.6 SP1 GATAD2A ZNF629 RFX1 IKZF1 POLR2A BACH1 TARDBP ZHX2 JUND ZFAT MIR30B ENSG00000272456 KHDRBS3
GH08J134682 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 11 +116.0 115988 3.6 CEBPG CTCF JUND FOXA1 ZNF143 RXRB REST RAD21 IRF2 IKZF2 ZFAT MIR30B ENSG00000272456 piR-61240-288
GH08J134754 Enhancer 1 Ensembl ENCODE 11.4 +46.2 46207 0.8 GATAD2A TFE3 SOX13 RCOR2 FOXA1 RXRB IRF2 SP1 CEBPA FOXK2 lnc-KHDRBS3-5 MIR30B MIR30D ENSG00000272456 ZFAT KHDRBS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30B Gene

Genomic Locations for MIR30B Gene
chr8:134,800,520-134,800,607
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr8:135,812,763-135,812,850
(GRCh37/hg19)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR30B Gene

Genes around MIR30B on UCSC Golden Path with GeneCards custom track
MIR30B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR30B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30B Gene

Proteins for MIR30B Gene

Post-translational modifications for MIR30B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30B Gene

Domains & Families for MIR30B Gene

Gene Families for MIR30B Gene

genes like me logo Genes that share domains with MIR30B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30B Gene

Function for MIR30B Gene

Phenotypes From GWAS Catalog for MIR30B Gene

Gene Ontology (GO) - Molecular Function for MIR30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22387553
genes like me logo Genes that share ontologies with MIR30B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30B Gene

Localization for MIR30B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30B gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30B Gene

Pathways & Interactions for MIR30B Gene

genes like me logo Genes that share pathways with MIR30B: view

Pathways by source for MIR30B Gene

1 BioSystems pathway for MIR30B Gene
1 KEGG pathway for MIR30B Gene

Gene Ontology (GO) - Biological Process for MIR30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 28977001
GO:0010628 positive regulation of gene expression IDA 28977001
GO:0016525 negative regulation of angiogenesis IDA 28977001
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA 28977001
GO:0035195 gene silencing by miRNA IMP 23086751
genes like me logo Genes that share ontologies with MIR30B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30B Gene

Drugs & Compounds for MIR30B Gene

No Compound Related Data Available

Transcripts for MIR30B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00002152A8_9606 miRNA 22 6

RefSeq: NR_029666,

LncBase: hsa-miR-30b-3p,

miRBase: MIMAT0004589,

MirGeneDB: Hsa-Mir-30-P2c_3p,

TarBase: hsa-miR-30b-3p,

ENA: LM380267.1:1..22:ncRNA, LM608481.1:55..76:ncRNA,

URS00005165DA_9606 miRNA 22 6

RefSeq: NR_029666,

LncBase: hsa-miR-30b-5p,

miRBase: MIMAT0000420,

MirGeneDB: Hsa-Mir-30-P2c_5p,

TarBase: hsa-miR-30b-5p,

ENA: LM379038.1:1..22:ncRNA, LM608481.1:17..38:ncRNA,

URS00003426E6_9606 precursor_RNA 88 5

HGNC: 31625,

RefSeq: NR_029666,

Ensembl: ENST00000384850 (view in UCSC) ,

miRBase: MI0000441,

ENA: LM608481.1:1..88:precursor_RNA,

URS0000EFBDE0_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-30-P2c,

URS00006B7A1B_9606 precursor_RNA 58 1

Rfam: RF00131,

MIR30B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30B Gene

No ASD Table

Relevant External Links for MIR30B Gene

GeneLoc Exon Structure for
MIR30B

Expression for MIR30B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR30B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30B

Evidence on tissue expression from TISSUES for MIR30B Gene

  • Blood(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR30B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30B Gene

Orthologs for MIR30B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30b 31
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30b 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30b 31
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30b 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30b 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30b 31
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-30b 31
  • 86 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30b 31
  • 61 (a)
ManyToMany
Species where no ortholog for MIR30B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30B Gene

ENSEMBL:
Gene Tree for MIR30B (if available)
TreeFam:
Gene Tree for MIR30B (if available)

Paralogs for MIR30B Gene

No data available for Paralogs for MIR30B Gene

Variants for MIR30B Gene

Additional dbSNP identifiers (rs#s) for MIR30B Gene

Additional Variant Information for MIR30B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30B Gene

Disorders for MIR30B Gene

MalaCards: The human disease database

(37) MalaCards diseases for MIR30B Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR30B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30B Gene

Publications for MIR30B Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
  2. LncRNA MALAT1 potentiates autophagy‑associated cisplatin resistance by regulating the microRNA‑30b/autophagy‑related gene 5 axis in gastric cancer. (PMID: 30365113) Xi Z … Nan J (International journal of oncology 2019) 3
  3. Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven. (PMID: 31768184) Zhang L … Jia X (Cellular & molecular biology letters 2019) 3
  4. The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. (PMID: 31861407) Woo CC … Sorokin V (International journal of molecular sciences 2019) 3
  5. Functional analysis of miR-21-3p, miR-30b-5p and miR-150-5p shuttled by extracellular vesicles from diabetic subjects reveals their association with diabetic retinopathy. (PMID: 31002820) Mazzeo A … Beltramo E (Experimental eye research 2019) 3

Products for MIR30B Gene

Sources for MIR30B Gene