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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR30B (MicroRNA 30b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30B include Medulloblastoma and Lymphoma, Hodgkin, Classic. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22387553 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | miRNA targets in ECM and membrane receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | IDA | 28977001 |
GO:0010628 | positive regulation of gene expression | IDA | 28977001 |
GO:0016525 | negative regulation of angiogenesis | IDA | 28977001 |
GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | IDA | 28977001 |
GO:0035195 | gene silencing by miRNA | IMP | 23086751 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00002152A8_9606 | miRNA | 22 | 6 |
RefSeq: NR_029666, LncBase: hsa-miR-30b-3p, miRBase: MIMAT0004589, MirGeneDB: Hsa-Mir-30-P2c_3p, TarBase: hsa-miR-30b-3p, |
URS00005165DA_9606 | miRNA | 22 | 6 |
RefSeq: NR_029666, LncBase: hsa-miR-30b-5p, miRBase: MIMAT0000420, MirGeneDB: Hsa-Mir-30-P2c_5p, TarBase: hsa-miR-30b-5p, |
URS00003426E6_9606 | precursor_RNA | 88 | 5 |
HGNC: 31625, RefSeq: NR_029666, Ensembl: ENST00000384850 (view in UCSC) , miRBase: MI0000441, |
URS0000EFBDE0_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-30-P2c, |
URS00006B7A1B_9606 | precursor_RNA | 58 | 1 |
Rfam: RF00131, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-30b 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-30b 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-30b 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-30b 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir30b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-30b 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-30b 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-30b 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-30b 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
medulloblastoma |
|
|
lymphoma, hodgkin, classic |
|
|
nemaline myopathy |
|
|
muscular dystrophy, duchenne type |
|
|
schizophrenia |
|