microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR30A Gene

Subcategory (RNA class) for MIR30A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR30A Gene

  • MicroRNA 30a 2 3 5
  • Hsa-MiR-30a-3p 163 173
  • Hsa-MiR-30a-5p 163 173
  • Hsa-Mir-30a 2 3
  • MIR30A 2 5
  • Hsa-Mir-30-P1a 178
  • MIMAT0000088 50
  • MIMAT0000087 50
  • MI0000088 50
  • MIRN30A 3
  • Mir-30a 3
  • RF00131 168

External Ids for MIR30A Gene

Previous HGNC Symbols for MIR30A Gene

  • MIRN30A

Previous GeneCards Identifiers for MIR30A Gene

  • GC06M072172
  • GC06M072113

Summaries for MIR30A Gene

Entrez Gene Summary for MIR30A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is one of five members of the miR-30 family of highly conserved miRNAs and participates in many cellular processes. It has additionally been implicated in the development of several types of cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR30A Gene

MIR30A (MicroRNA 30a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30A include Glomerular Disease and Thyroid Gland Anaplastic Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR30A Gene

  • mir-30 microRNA precursor

Additional gene information for MIR30A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30A Gene

Genomics for MIR30A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR30A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J071365 Enhancer 0.9 Ensembl ENCODE 10.5 +36.7 36720 4.2 FOXA1 RELA ZSCAN4 IKZF2 PKNOX1 SCRT2 ARID3A ZSCAN29 DPF2 RELB OGFRL1 MIR30A lnc-OGFRL1-6 MIR30C2 ENSG00000269966 LINC00472 RIMS1
GH06J071508 Enhancer 0.8 Ensembl ENCODE 11.6 -106.2 -106244 1.9 CTCF RAD21 ZBTB44 RUNX3 ZSCAN5C SMC3 WT1 RFX5 GATA3 STAT1 MIR30A RIMS1 lnc-OGFRL1-12 ENSG00000285963 OGFRL1
GH06J071476 Enhancer 0.8 Ensembl ENCODE 10.9 -76.1 -76072 5.8 CTCF JUND ESR1 NR3C1 CEBPB JUN USF1 RCOR1 FOS NR2F2 MIR30A OGFRL1 lnc-OGFRL1-3 LOC105377853 RF00994-914 RIMS1
GH06J071489 Enhancer 0.7 Ensembl ENCODE 11.1 -86.7 -86680 2.6 JUND CTBP1 JUN FOS DPF2 GATA3 ZNF217 BACH1 NFE2L2 ZNF384 MIR30A RIMS1 ENSG00000232295 LINC00472 RF00994-914 lnc-OGFRL1-3 OGFRL1
GH06J071473 Enhancer 0.6 Ensembl ENCODE 11.1 -70.5 -70523 1.1 FOS USF2 JUN MAX NR3C1 lnc-OGFRL1-3 MIR30A LOC105377853 OGFRL1 RIMS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR30A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR30A Gene

Genomic Locations for MIR30A Gene
chr6:71,403,551-71,403,621
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand
chr6:72,113,254-72,113,324
(GRCh37/hg19)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR30A Gene

Genes around MIR30A on UCSC Golden Path with GeneCards custom track
MIR30A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR30A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30A Gene

Proteins for MIR30A Gene

Post-translational modifications for MIR30A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30A Gene

Domains & Families for MIR30A Gene

Gene Families for MIR30A Gene

genes like me logo Genes that share domains with MIR30A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR30A Gene

Function for MIR30A Gene

Phenotypes From GWAS Catalog for MIR30A Gene

Gene Ontology (GO) - Molecular Function for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP,IDA 23086751
genes like me logo Genes that share ontologies with MIR30A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30A Gene

Localization for MIR30A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR30A gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR30A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR30A Gene

Pathways & Interactions for MIR30A Gene

PathCards logo

SuperPathways for MIR30A Gene

genes like me logo Genes that share pathways with MIR30A: view

Pathways by source for MIR30A Gene

1 BioSystems pathway for MIR30A Gene
1 KEGG pathway for MIR30A Gene

Gene Ontology (GO) - Biological Process for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 23960241
GO:0010628 positive regulation of gene expression IMP --
GO:0030335 positive regulation of cell migration IMP --
GO:0035195 gene silencing by miRNA IMP 23086751
GO:0035278 miRNA mediated inhibition of translation IMP --
genes like me logo Genes that share ontologies with MIR30A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR30A Gene

Drugs & Compounds for MIR30A Gene

No Compound Related Data Available

Transcripts for MIR30A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR30A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000065D58_9606 miRNA 22 6

RefSeq: NR_029504,

LncBase: hsa-miR-30a-3p,

miRBase: MIMAT0000088,

MirGeneDB: Hsa-Mir-30-P1a_3p,

TarBase: hsa-miR-30a-3p,

ENA: AJ421752.1:1..22:misc_RNA, LM378775.1:1..22:ncRNA, LM608177.1:47..68:ncRNA,

URS000043D261_9606 precursor_RNA 71 5

HGNC: 31624,

RefSeq: NR_029504,

Ensembl: ENST00000385092 (view in UCSC) ,

miRBase: MI0000088,

ENA: LM608177.1:1..71:precursor_RNA,

URS000043D1A9_9606 miRNA 22 5

RefSeq: NR_029504,

LncBase: hsa-miR-30a-5p,

miRBase: MIMAT0000087,

TarBase: hsa-miR-30a-5p,

ENA: LM378774.1:1..22:ncRNA, LM608177.1:6..27:ncRNA,

URS0000EFE1FD_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-30-P1a,

URS0000704D62_9606 precursor_RNA 61 1

Rfam: RF00131,

MIR30A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR30A Gene

4 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30A Gene

No ASD Table

Relevant External Links for MIR30A Gene

GeneLoc Exon Structure for
MIR30A

Expression for MIR30A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR30A

Evidence on tissue expression from TISSUES for MIR30A Gene

  • Blood(2.3)
  • Heart(2.1)
  • Muscle(2.1)
  • Nervous system(2.1)
  • Kidney(2.1)
  • Liver(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30A Gene

Orthologs for MIR30A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30a 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-30a 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-30a 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30a 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir30a 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30a 31
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-30a 31
  • 82 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-30a 31
  • 47 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-30e-2 31
  • 69 (a)
OneToOne
Species where no ortholog for MIR30A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR30A Gene

ENSEMBL:
Gene Tree for MIR30A (if available)
TreeFam:
Gene Tree for MIR30A (if available)

Paralogs for MIR30A Gene

No data available for Paralogs for MIR30A Gene

Variants for MIR30A Gene

Additional dbSNP identifiers (rs#s) for MIR30A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR30A Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER inversion 21111241
nsv603640 CNV gain 21841781
nsv7382 OTHER inversion 18451855
nsv830684 CNV gain 17160897

Additional Variant Information for MIR30A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR30A Gene

Disorders for MIR30A Gene

MalaCards: The human disease database

(112) MalaCards diseases for MIR30A Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR30A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR30A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30A Gene

Publications for MIR30A Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  4. Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. (PMID: 31678166) Georgikou C … Herr I (Cancer letters 2020) 3
  5. MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/β-catenin signaling axis. (PMID: 30338942) Jiang S … Tong J (Journal of cellular and molecular medicine 2019) 3

Products for MIR30A Gene

Sources for MIR30A Gene