microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3074 Gene

Subcategory (RNA class) for MIR3074 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR3074 Gene

  • MicroRNA 3074 2 3 5
  • Hsa-Mir-3074 2 3
  • MIR3074 2 5
  • Hsa-MiR-3074-3p 173
  • Hsa-MiR-3074-5p 173
  • MIMAT0019208 50
  • MIMAT0015027 50
  • MI0014181 50
  • Mir-3074 3

External Ids for MIR3074 Gene

Previous GeneCards Identifiers for MIR3074 Gene

  • GC09U901548
  • GC09M067457
  • GC09M097848

Summaries for MIR3074 Gene

Entrez Gene Summary for MIR3074 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3074 Gene

MIR3074 (MicroRNA 3074) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3074 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Hematopoietic Stem Cell Differentiation and DNA Damage Response.

Rfam classification for MIR3074 Gene

  • mir-24 microRNA precursor family

Additional gene information for MIR3074 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR3074 Gene

Genomics for MIR3074 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3074 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J095084 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 +0.8 772 3 HNRNPL ESR1 RBM22 CTCF POLR2A MIR23B MIR24-1 MIR27B MIR3074 lnc-MFSD14B-20 NONHSAG052915.2 AOPEP FANCC
GH09J095016 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.2 +64.2 64247 10.7 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 CTCF RCOR2 ZNF7 FOXA1 PRDM1 MIR23B MIR27B MIR3074 AOPEP lnc-MFSD14B-18 lnc-MFSD14B-7 NONHSAG052915.2 FANCC
GH09J095060 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.7 +22.0 21998 6.2 GATAD2A TFE3 RXRB IRF2 SP1 GABPA TOE1 CEBPA FOXK2 SOX13 MIR6081 MIR23B MIR27B MIR3074 AOPEP piR-43107-304 NONHSAG052915.2 FANCC
GH09J095053 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 12.6 +29.2 29222 6.2 PRDM10 ZNF629 FOXA1 ZIC2 POLR2A ZBTB44 SP1 TCF7L2 CEBPB OSR2 MIR23B MIR27B MIR3074 MIR6081 piR-43107-304 NONHSAG052915.2 AOPEP FANCC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3074 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3074 Gene

Genomic Locations for MIR3074 Gene
chr9:95,086,014-95,086,094
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr9:97,848,296-97,848,376
(GRCh37/hg19)
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR3074 Gene

Genes around MIR3074 on UCSC Golden Path with GeneCards custom track
MIR3074 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3074 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3074 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3074 Gene

Proteins for MIR3074 Gene

Post-translational modifications for MIR3074 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3074 Gene

Domains & Families for MIR3074 Gene

Gene Families for MIR3074 Gene

HGNC:
genes like me logo Genes that share domains with MIR3074: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3074 Gene

Function for MIR3074 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3074 Gene

Localization for MIR3074 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR3074 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3074 Gene

Pathways & Interactions for MIR3074 Gene

genes like me logo Genes that share pathways with MIR3074: view

Gene Ontology (GO) - Biological Process for MIR3074 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR3074: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR3074 Gene

Drugs & Compounds for MIR3074 Gene

No Compound Related Data Available

Transcripts for MIR3074 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3074 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CA56_9606 precursor_RNA 81 5

HGNC: 38268,

RefSeq: NR_036109,

Ensembl: ENST00000384885 (view in UCSC) ,

miRBase: MI0014181,

ENA: LM611006.1:1..81:precursor_RNA,

URS000046F124_9606 miRNA 22 4

RefSeq: NR_036109,

miRBase: MIMAT0015027,

TarBase: hsa-miR-3074-3p,

ENA: FR772707.1:1..22:ncRNA, LM611006.1:50..71:ncRNA,

URS0000166778_9606 miRNA 21 4

RefSeq: NR_036109,

miRBase: MIMAT0019208,

TarBase: hsa-miR-3074-5p,

ENA: FR772708.1:1..21:ncRNA, LM382498.1:1..21:ncRNA, LM611006.1:12..32:ncRNA,

MIR3074 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3074 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3074 Gene

No ASD Table

Relevant External Links for MIR3074 Gene

GeneLoc Exon Structure for
MIR3074

Expression for MIR3074 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3074 Gene

genes like me logo Genes that share expression patterns with MIR3074: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3074 Gene

Orthologs for MIR3074 Gene

Evolution for MIR3074 Gene

ENSEMBL:
Gene Tree for MIR3074 (if available)
TreeFam:
Gene Tree for MIR3074 (if available)

No data available for Orthologs for MIR3074 Gene

Paralogs for MIR3074 Gene

No data available for Paralogs for MIR3074 Gene

Variants for MIR3074 Gene

Additional dbSNP identifiers (rs#s) for MIR3074 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3074 Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Additional Variant Information for MIR3074 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3074

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3074 Gene

Disorders for MIR3074 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3074 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary, 1
  • rccp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3074

genes like me logo Genes that share disorders with MIR3074: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3074 Gene

Publications for MIR3074 Gene

  1. miR-3074-5p Promotes the Apoptosis but Inhibits the Invasiveness of Human Extravillous Trophoblast-Derived HTR8/SVneo Cells In Vitro. (PMID: 28826362) Gu Y … Wang J (Reproductive sciences (Thousand Oaks, Calif.) 2018) 3
  2. High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. (PMID: 27835701) Navarro-Quiroz E … Aroca G (PloS one 2016) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  5. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3

Products for MIR3074 Gene

Sources for MIR3074 Gene