microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR301A Gene

Subcategory (RNA class) for MIR301A Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR301A Gene

  • MicroRNA 301a 2 3 5
  • Hsa-MiR-301a-3p 168 179
  • Hsa-MiR-301a-5p 168 179
  • MicroRNA 301 2 3
  • Hsa-Mir-301a 3
  • MIMAT0000688 53
  • MIMAT0022696 53
  • Hsa-Mir-301 3
  • MI0000745 53
  • Mir-301a 3
  • MIRN301A 3
  • MIRN301 3
  • MIR301A 2
  • RF02061 174
  • MIR301 3

External Ids for MIR301A Gene

Previous HGNC Symbols for MIR301A Gene

  • MIRN301
  • MIRN301A

Previous GeneCards Identifiers for MIR301A Gene

  • GC17M054587
  • GC17M057228

Summaries for MIR301A Gene

Entrez Gene Summary for MIR301A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301A Gene

MIR301A (MicroRNA 301a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR301A include Hepatitis B and Follicular Lymphoma.

Rfam classification for MIR301A Gene

Additional gene information for MIR301A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR301A Gene

Genomics for MIR301A Gene

GeneHancer (GH) Regulatory Elements for MIR301A Gene

Promoters and enhancers for MIR301A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J059148 Enhancer 0.5 ENCODE 750.6 +1.6 1631 2.3 ZKSCAN8 ZBTB8A ZNF316 FOSL2 FOS JUND ZNF664 SP1 MIR301A RAD51C TRIM37 SKA2 lnc-TRIM37-1-001 MIR454
GH17J059110 Enhancer 0.5 dbSUPER 11.6 +39.2 39189 2.7 ZNF362 ZNF384 PKNOX1 ZNF157 PRDM6 TRIM37 MIR301A MIR454 PRR11 SKA2 lnc-PRR11-4 ENSG00000224738 RF00004-057 RNU2-58P lnc-TRIM37-1-001
GH17J059046 Enhancer 0.5 ENCODE 11 +104.8 104796 0.1 ATF1 EP300 FOSL1 CREM ATF7 MIR301A SMG8 MTMR4 piR-34911-012 lnc-PPM1E-3 RN7SL716P TRIM37
GH17J059123 Enhancer 0.4 FANTOM5 12.2 +28.0 28019 0.1 ZNF362 ZNF121 MIR301A PRR11 SKA2 SMG8 GDPD1 RF00004-057 RNU2-58P lnc-PRR11-4 lnc-TRIM37-1-001
GH17J059121 Enhancer 0.3 dbSUPER 12.2 +29.1 29078 0.6 ZNF362 MIR301A PRR11 SKA2 SMG8 RF00004-057 RNU2-58P lnc-PRR11-4 lnc-TRIM37-1-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR301A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR301A Gene

Genomic Locations for MIR301A Gene
chr17:59,151,136-59,151,221
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr17:57,228,497-57,228,582
(GRCh37/hg19)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR301A Gene

Genes around MIR301A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR301A Gene

Proteins for MIR301A Gene

Post-translational modifications for MIR301A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301A Gene

Domains & Families for MIR301A Gene

Gene Families for MIR301A Gene

genes like me logo Genes that share domains with MIR301A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR301A Gene

Function for MIR301A Gene

Gene Ontology (GO) - Molecular Function for MIR301A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25681685
genes like me logo Genes that share ontologies with MIR301A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301A Gene

Localization for MIR301A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR301A gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR301A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR301A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR301A Gene

Pathways & Interactions for MIR301A Gene

PathCards logo

SuperPathways for MIR301A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR301A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 25681685
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA 25681685
genes like me logo Genes that share ontologies with MIR301A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR301A Gene

Drugs & Compounds for MIR301A Gene

No Compound Related Data Available

Transcripts for MIR301A Gene

mRNA/cDNA for MIR301A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) LncBase transcripts :
(5) ENA transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :
(2) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301A Gene

No ASD Table

Relevant External Links for MIR301A Gene

GeneLoc Exon Structure for
MIR301A
ECgene alternative splicing isoforms for
MIR301A

Expression for MIR301A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR301A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR301A Gene:

MIR301A
genes like me logo Genes that share expression patterns with MIR301A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR301A Gene

Orthologs for MIR301A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-301a 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-301a 33
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-301 33
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-301a 33
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir301 33
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-301 33
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-301b 33
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-301a 33
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-301a 33
  • 79 (a)
OneToMany
dre-mir-130a 33
  • 51 (a)
OneToMany
Species where no ortholog for MIR301A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301A Gene

ENSEMBL:
Gene Tree for MIR301A (if available)
TreeFam:
Gene Tree for MIR301A (if available)

Paralogs for MIR301A Gene

No data available for Paralogs for MIR301A Gene

Variants for MIR301A Gene

Sequence variations from dbSNP and Humsavar for MIR301A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001565228 -- 59,151,970(-) T/C/G upstream_transcript_variant
rs1001994806 -- 59,151,584(-) A/G upstream_transcript_variant
rs1005672495 -- 59,152,789(-) T/C upstream_transcript_variant
rs1007392127 -- 59,150,934(-) A/C downstream_transcript_variant
rs1009932346 -- 59,152,957(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR301A Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
esv2758699 CNV gain 17122850
esv3573764 CNV gain 25503493
nsv1065063 CNV gain 25217958
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Additional Variant Information for MIR301A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR301A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR301A Gene

Disorders for MIR301A Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR301A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
follicular lymphoma
  • lymphoma, follicular
cholangiocarcinoma
  • cca
pancreatic cancer
  • pancreatic carcinoma
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR301A

genes like me logo Genes that share disorders with MIR301A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR301A Gene

Publications for MIR301A Gene

  1. MicroRNA-200b and -301 are associated with gemcitabine response as biomarkers in pancreatic carcinoma cells. (PMID: 30628651) Funamizu N … Manome Y (International journal of oncology 2019) 3 56
  2. Hyperglycaemia-induced miR-301a promotes cell proliferation by repressing p21 and Smad4 in prostate cancer. (PMID: 29331421) Li X … Wen X (Cancer letters 2018) 3 56
  3. Knockdown of Urothelial Carcinoma-Associated 1 Suppressed Cell Growth and Migration Through Regulating miR-301a and CXCR4 in Osteosarcoma MHCC97 Cells. (PMID: 29523218) Zhu G … Lin Z (Oncology research 2018) 3 56
  4. MiR-301a-3p Suppresses Estrogen Signaling by Directly Inhibiting ESR1 in ERα Positive Breast Cancer. (PMID: 29763890) Lettlova S … Truksa J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 56
  5. Long Noncoding RNA GAS5 Promotes Proliferation, Migration, and Invasion by Regulation of miR-301a in Esophageal Cancer. (PMID: 29386089) Li W … Yang X (Oncology research 2018) 3 56

Products for MIR301A Gene

Sources for MIR301A Gene