microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR300 Gene

Subcategory (RNA class) for MIR300 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR300 Gene

  • MicroRNA 300 2 3 5
  • Hsa-Mir-300 2 3
  • MIR300 2 5
  • MIMAT0004903 50
  • Hsa-MiR-300 173
  • MI0005525 50
  • MIRN300 3
  • RF00641 168

External Ids for MIR300 Gene

Previous HGNC Symbols for MIR300 Gene

  • MIRN300

Previous GeneCards Identifiers for MIR300 Gene

  • GC14P100823
  • GC14P100866
  • GC14P101512
  • GC14P101541
  • GC14P101574
  • GC14P101615
  • GC14P101643
  • GC14P101676
  • GC14P101713
  • GC14P101755
  • GC14P101814
  • GC14P101954
  • GC14P102150
  • GC14P101252
  • GC14P101859
  • GC14P103605
  • GC14P103822
  • GC14P104097
  • GC14P104441
  • GC14P102112
  • GC14P102348
  • GC14P102519
  • GC14P102698
  • GC14P102866
  • GC14P103042
  • GC14P103236
  • GC14P103423

Summaries for MIR300 Gene

Entrez Gene Summary for MIR300 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR300 Gene

MIR300 (MicroRNA 300) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR300 Gene

Additional gene information for MIR300 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR300 Gene

Genomics for MIR300 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR300 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR300 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR300 Gene

Genomic Locations for MIR300 Gene
chr14:101,041,363-101,041,445
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr14:101,507,700-101,507,782
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR300 Gene

Genes around MIR300 on UCSC Golden Path with GeneCards custom track
MIR300 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR300 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR300 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR300 Gene

Proteins for MIR300 Gene

Post-translational modifications for MIR300 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR300 Gene

Domains & Families for MIR300 Gene

Gene Families for MIR300 Gene

HGNC:
genes like me logo Genes that share domains with MIR300: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR300 Gene

Function for MIR300 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR300 Gene

Localization for MIR300 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR300 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR300 Gene

Pathways & Interactions for MIR300 Gene

PathCards logo

SuperPathways for MIR300 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR300 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR300: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR300 Gene

Drugs & Compounds for MIR300 Gene

No Compound Related Data Available

Transcripts for MIR300 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR300 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D97A_9606 precursor_RNA 83 4

HGNC: 33636,

RefSeq: NR_030582,

Ensembl: ENST00000401138 (view in UCSC) ,

miRBase: MI0005525,

URS000075CFC2_9606 miRNA 22 3

RefSeq: NR_030582,

miRBase: MIMAT0004903,

TarBase: hsa-miR-300,

URS000069D04A_9606 precursor_RNA 79 1

Rfam: RF00641,

URS000072D1D2_9606 precursor_RNA 79 1

Rfam: RF00641,

MIR300 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR300 Gene

No ASD Table

Relevant External Links for MIR300 Gene

GeneLoc Exon Structure for
MIR300

No data available for mRNA/cDNA for MIR300 Gene

Expression for MIR300 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR300 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR300

genes like me logo Genes that share expression patterns with MIR300: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR300 Gene

Orthologs for MIR300 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR300 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-300 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-300 31
  • 79 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia mmu-mir-300 31
  • 74 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-453 31
  • 34 (a)
OneToOne
Species where no ortholog for MIR300 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR300 Gene

ENSEMBL:
Gene Tree for MIR300 (if available)
TreeFam:
Gene Tree for MIR300 (if available)

Paralogs for MIR300 Gene

No data available for Paralogs for MIR300 Gene

Variants for MIR300 Gene

Additional dbSNP identifiers (rs#s) for MIR300 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR300 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR300 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR300

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR300 Gene

Disorders for MIR300 Gene

Additional Disease Information for MIR300

No disorders were found for MIR300 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR300 Gene

Publications for MIR300 Gene

  1. miR‑300 regulates tumor proliferation and metastasis by targeting lymphoid enhancer‑binding factor 1 in hepatocellular carcinoma. (PMID: 30968150) Chen Y … Wang R (International journal of oncology 2019) 3
  2. MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells. (PMID: 28685847) Zhang JQ … Peng CH (Journal of cellular biochemistry 2018) 3
  3. Upregulation of microRNA‑300 induces the proliferation of liver cancer by downregulating transcription factor FOXO1. (PMID: 30272296) Chang Y … Li X (Oncology reports 2018) 3
  4. MIR-300 in the imprinted DLK1-DIO3 domain suppresses the migration of bladder cancer by regulating the SP1/MMP9 pathway. (PMID: 30526300) Yan H … Zheng X (Cell cycle (Georgetown, Tex.) 2018) 3
  5. MiR-300 Serves as Potential Biomarker to Screen Knee Osteoarthritis Patients by Targeting TNFα. (PMID: 29739086) Zhou Z … Guo L (Clinical laboratory 2018) 3

Products for MIR300 Gene

Sources for MIR300 Gene