microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR29C Gene

Subcategory (RNA class) for MIR29C Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR29C Gene

  • MicroRNA 29c 2 3 5
  • Hsa-MiR-29c-3p 163 173
  • Hsa-MiR-29c-5p 163 173
  • Hsa-Mir-29c 2 3
  • MIR29C 2 5
  • Hsa-Mir-29-P1b 178
  • MIMAT0004673 50
  • MIMAT0000681 50
  • MI0000735 50
  • MiRNA29C 3
  • MIRN29C 3
  • Mir-29c 3
  • RF00074 168

External Ids for MIR29C Gene

Previous HGNC Symbols for MIR29C Gene

  • MIRN29C

Previous GeneCards Identifiers for MIR29C Gene

  • GC01M206043
  • GC01M207975

Summaries for MIR29C Gene

Entrez Gene Summary for MIR29C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29C Gene

MIR29C (MicroRNA 29c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29C include Huntington Disease and Rhabdomyosarcoma. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

Rfam classification for MIR29C Gene

  • mir-29 microRNA precursor

Additional gene information for MIR29C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29C Gene

Genomics for MIR29C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR29C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J207800 Enhancer 0.3 Ensembl 600.7 +1.3 1339 0.4 POLR2A MIR29B2 MIR29C RF00017-460 CD46 MIR29B2CHG CD34
GH01J207778 Enhancer 0.8 Ensembl 12.1 +22.8 22838 0.2 LEF1 IKZF1 JUND MTA1 NR2C1 DPF2 HDAC1 SOX6 FOXJ2 TCF12 MIR29C MIR29B2CHG NONHSAG004137.2 RF00017-460 CD46 CD34
GH01J207796 Enhancer 1 Ensembl ENCODE 0.7 +3.4 3438 3.4 CTCF JUND FOXA1 DDX20 PKNOX1 REST RAD21 BRD9 ZNF501 POLR2A CD46 CR1L MIR29C RF00017-460 MIR29B2CHG CD34
GH01J207789 Enhancer 0.7 Ensembl ENCODE 0.4 +11.3 11318 2.6 ATF7 ZHX2 PRDM1 CTBP1 RBM22 ATF2 GATA3 DPF2 TCF7L2 HLF CR1L RF00017-460 MIR29C NONHSAG004137.2 CD46 MIR29B2CHG CD34
GH01J207794 Enhancer 0.3 Ensembl 0.4 +7.6 7638 0.2 RBM22 SUPT5H CD46 MIR29C RF00017-460 NONHSAG004137.2 MIR29B2CHG CD34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR29C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR29C Gene

Genomic Locations for MIR29C Gene
chr1:207,801,852-207,801,939
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr1:207,974,863-208,042,495
(GRCh37/hg19)
Size:
67,633 bases
Orientation:
Minus strand

Genomic View for MIR29C Gene

Genes around MIR29C on UCSC Golden Path with GeneCards custom track
MIR29C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR29C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29C Gene

Proteins for MIR29C Gene

Post-translational modifications for MIR29C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29C Gene

Domains & Families for MIR29C Gene

Gene Families for MIR29C Gene

genes like me logo Genes that share domains with MIR29C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29C Gene

Function for MIR29C Gene

Phenotypes From GWAS Catalog for MIR29C Gene

Gene Ontology (GO) - Molecular Function for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18390668
genes like me logo Genes that share ontologies with MIR29C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29C Gene

Localization for MIR29C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR29C gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR29C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29C Gene

Pathways & Interactions for MIR29C Gene

PathCards logo

SuperPathways for MIR29C Gene

genes like me logo Genes that share pathways with MIR29C: view

Pathways by source for MIR29C Gene

1 BioSystems pathway for MIR29C Gene
1 KEGG pathway for MIR29C Gene

Gene Ontology (GO) - Biological Process for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 23936390
GO:0008285 negative regulation of cell proliferation IDA 20086245
GO:0010629 negative regulation of gene expression IDA 20570858
GO:0016525 negative regulation of angiogenesis IDA 26175848
GO:0030336 negative regulation of cell migration IDA 23936390
genes like me logo Genes that share ontologies with MIR29C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR29C Gene

Drugs & Compounds for MIR29C Gene

No Compound Related Data Available

Transcripts for MIR29C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29C Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000272A3D_9606 miRNA 22 6

RefSeq: NR_029832,

LncBase: hsa-miR-29c-3p,

miRBase: MIMAT0000681,

MirGeneDB: Hsa-Mir-29-P1b_3p,

TarBase: hsa-miR-29c-3p,

ENA: LM379201.1:1..22:ncRNA, LM608662.1:54..75:ncRNA,

URS000075B799_9606 precursor_RNA 88 5

HGNC: 31621,

RefSeq: NR_029832,

Ensembl: ENST00000385231 (view in UCSC) ,

miRBase: MI0000735,

ENA: LM608662.1:1..88:precursor_RNA,

URS0000497496_9606 miRNA 22 5

RefSeq: NR_029832,

LncBase: hsa-miR-29c-5p,

miRBase: MIMAT0004673,

TarBase: hsa-miR-29c-5p,

ENA: EU154351.1:1660..1681:ncRNA, EU154352.1:1845..1866:ncRNA, LM380337.1:1..22:ncRNA, LM608662.1:16..37:ncRNA,

URS000042E914_9606 precursor_RNA 62 1

Rfam: RF00074,

URS0000EFC5C7_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-29-P1b,

MIR29C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR29C Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29C Gene

No ASD Table

Relevant External Links for MIR29C Gene

GeneLoc Exon Structure for
MIR29C

Expression for MIR29C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29C

Evidence on tissue expression from TISSUES for MIR29C Gene

  • Blood(2.3)
  • Muscle(2.2)
  • Heart(2.1)
  • Liver(2.1)
  • Nervous system(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MIR29C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29C Gene

Orthologs for MIR29C Gene

Evolution for MIR29C Gene

ENSEMBL:
Gene Tree for MIR29C (if available)
TreeFam:
Gene Tree for MIR29C (if available)

No data available for Orthologs for MIR29C Gene

Paralogs for MIR29C Gene

No data available for Paralogs for MIR29C Gene

Variants for MIR29C Gene

Additional dbSNP identifiers (rs#s) for MIR29C Gene

Additional Variant Information for MIR29C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29C Gene

Disorders for MIR29C Gene

MalaCards: The human disease database

(63) MalaCards diseases for MIR29C Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR29C

genes like me logo Genes that share disorders with MIR29C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29C Gene

Publications for MIR29C Gene

  1. MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells. (PMID: 30513336) Cai J … Wu S (Experimental cell research 2019) 3
  2. LINC00511 knockdown enhances paclitaxel cytotoxicity in breast cancer via regulating miR-29c/CDK6 axis. (PMID: 31047896) Zhang H … Yu W (Life sciences 2019) 3
  3. miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma. (PMID: 30718452) Wu H … Liu C (Cell death & disease 2019) 3
  4. MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia. (PMID: 31097000) Liu B … Jia L (Journal of experimental & clinical cancer research : CR 2019) 3
  5. Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer. (PMID: 31497917) Han Y … Xie X (Cell proliferation 2019) 3

Products for MIR29C Gene

Sources for MIR29C Gene