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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR29C Gene
RNA type for MIR29C Gene
miRNA
Aliases for MIR29C Gene
- MIMAT0004673 (miRBase)
- MI0000735 (miRBase)
- MiRNA29C (NCBI Entrez Gene)
- MIRN29C (NCBI Entrez Gene)
- Mir-29c (NCBI Entrez Gene)
- RF00074 (Rfam)
- MIR29C (Ensembl)
External Ids for MIR29C Gene
- HGNC: 31621
- NCBI Entrez Gene: 407026
- Ensembl: ENSG00000284214
- OMIM®: 610784
- miRBase: hsa-mir-29c
Previous HGNC Symbols for MIR29C Gene
- MIRN29C
Previous GeneCards Identifiers for MIR29C Gene
- GC01M206043
- GC01M207975
Summaries for MIR29C Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR29C Gene
MIR29C (MicroRNA 29c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29C include Nasopharyngeal Carcinoma and Huntington Disease. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
Rfam classification for MIR29C Gene
-
mir-29 microRNA precursor
Additional gene information for MIR29C Gene
- HGNC (31621)
- NCBI Entrez Gene (407026)
- Ensembl (ENSG00000284214)
- OMIM® (610784)
- Open Targets Platform(ENSG00000284214)
- Alliance of Genome Resources
- Search for MIR29C at DataMed
- Search for MIR29C at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29C Gene
Genomics for MIR29C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR29C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J207800 | Enhancer | 0.3 | Ensembl | 250.7 | +1.4 | 1438 | 0.2 | POLR2A | MIR29C HSALNG0010126 CD46 MIR29B2CHG CD34 | |
| GH01J207778 | Enhancer | 0.8 | Ensembl | 12.1 | +22.8 | 22838 | 0.2 | IKZF1 NCOR1 NFIC ARNT NBN TAL1 ATF1 SPI1 SMARCA4 EHMT2 | MIR29C MIR29B2CHG RF00017-403 NONHSAG004137.2 CD46 CD34 | |
| GH01J207796 | Enhancer | 1 | Ensembl ENCODE | 0.7 | +3.3 | 3349 | 3.2 | ZNF654 JUND POLR2A CTCF CEBPB REST DEK TRIM22 ARNT RAD21 | CD46 CR1L HSALNG0010126 MIR29C MIR29B2CHG CD34 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR29C on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR29C Gene
Latest Assembly
- chr1:207,801,852-207,801,939
- (GRCh38/hg38)
- Size:
- 88 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:207,975,197-207,975,284
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 88 bases
- Orientation:
- Minus strand
Genomic View for MIR29C Gene
Genes around MIR29C on UCSC Golden Path with GeneCards custom track
MIR29C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1q32.2 by HGNC
- 1q32.2 by Entrez Gene
- 1q32.2 by Ensembl
MIR29C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR29C Gene
Proteins for MIR29C Gene
Post-translational modifications for MIR29C Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR29C Gene
Domains & Families for MIR29C Gene
Gene Families for MIR29C Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29C Gene
Function for MIR29C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 21565331 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 18390668 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR29C - Starting at $85 >
- * MIR29C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR29C - Starting at $45 >
- * MIR29C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29C Gene
Localization for MIR29C Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 28159509 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29C Gene
Pathways & Interactions for MIR29C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
Pathways by source for MIR29C Gene
1 BioSystems pathway for MIR29C Gene
1 KEGG pathway for MIR29C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 23936390 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 20086245 |
| GO:0010629 | negative regulation of gene expression | IDA | 20570858 |
| GO:0016525 | negative regulation of angiogenesis | IDA | 26175848 |
| GO:0030336 | negative regulation of cell migration | IDA | 23936390 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR29C Gene
Transcripts for MIR29C Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29C Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000272A3D_9606 | miRNA | 22 | 6 |
RefSeq: NR_029832, LncBase: hsa-miR-29c-3p, miRBase: MIMAT0000681, MirGeneDB: Hsa-Mir-29-P1b_3p, TarBase: hsa-miR-29c-3p, |
| URS0000497496_9606 | miRNA | 22 | 5 |
RefSeq: NR_029832, LncBase: hsa-miR-29c-5p, miRBase: MIMAT0004673, TarBase: hsa-miR-29c-5p, ENA: EU154351.1:1660..1681:ncRNA, EU154352.1:1845..1866:ncRNA, LM380337.1:1..22:ncRNA, LM608662.1:16..37:ncRNA, |
| URS000075B799_9606 | pre_miRNA | 88 | 4 |
RefSeq: NR_029832, Ensembl: ENST00000385231 (view in UCSC) , miRBase: MI0000735, |
| URS000042E914_9606 | pre_miRNA | 62 | 1 |
Rfam: RF00074, |
| URS0000EFC5C7_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-29-P1b, |
MIR29C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR29C Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR29C - Starting at $85 >
- * MIR29C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR29C - Starting at $45 >
- * MIR29C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR29C Gene
- GeneLoc Exon Structure for
- MIR29C
Expression for MIR29C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29C
Evidence on tissue expression from TISSUES for MIR29C Gene
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MIR29C
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29C Gene
Orthologs for MIR29C Gene
Evolution for MIR29C Gene
- ENSEMBL:
- Gene Tree for MIR29C (if available)
- TreeFam:
- Gene Tree for MIR29C (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR29C
No data available for Orthologs for MIR29C Gene
Paralogs for MIR29C Gene
No data available for Paralogs for MIR29C Gene
Variants for MIR29C Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR29C Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29C Gene
Disorders for MIR29C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nasopharyngeal carcinoma |
|
|
| huntington disease |
|
|
| rhabdomyosarcoma |
|
|
| type 2 diabetes mellitus |
|
|
| lung cancer |
|
Search MIR29C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR29C
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29C Gene
Publications for MIR29C Gene
- MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. (PMID: 18390668) Sengupta S … Ahlquist P (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 72
- miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway. (PMID: 31885310) Hu Z … Guo R (Cell cycle (Georgetown, Tex.) 2020) 3
- MiR-29b-3p cooperates with miR-29c-3p to affect the malignant biological behaviors in T-cell acute lymphoblastic leukemia via TFAP2C/GPX1 axis. (PMID: 32423796) Zhuang M … Zhang X (Biochemical and biophysical research communications 2020) 3
- Long Noncoding RNA SERTAD2-3 Inhibits Osteosarcoma Proliferation and Migration by Competitively Binding miR-29c. (PMID: 31999493) Zhang Z … Zhang X (Genetic testing and molecular biomarkers 2020) 3
- Reduced expression of exosomal miR‑29s in peritoneal fluid is a useful predictor of peritoneal recurrence after curative resection of gastric cancer with serosal involvement. (PMID: 32323853) Ohzawa H … Kitayama J (Oncology reports 2020) 3
ExternalLinks
Products for MIR29C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR29C
- Origene Custom Protein Services for MIR29C
- Browse OriGene Inhibitory RNA Products For MIR29C
- OriGene qPCR primer pairs for MIR29C
- Browse CRISPR knockouts for MIR29C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR29C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR29C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR29C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR29C
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR29C
Sources for MIR29C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources