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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR29C Gene
Subcategory (RNA class) for MIR29C Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR29C Gene
External Ids for MIR29C Gene
- HGNC: 31621
- Entrez Gene: 407026
- Ensembl: ENSG00000284214
- OMIM: 610784
- miRBase: hsa-mir-29c
Previous HGNC Symbols for MIR29C Gene
- MIRN29C
Previous GeneCards Identifiers for MIR29C Gene
- GC01M206043
- GC01M207975
Summaries for MIR29C Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR29C Gene
MIR29C (MicroRNA 29c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29C include Huntington Disease and Rhabdomyosarcoma. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.
Rfam classification for MIR29C Gene
-
mir-29 microRNA precursor
Additional gene information for MIR29C Gene
- HGNC(31621)
- Entrez Gene(407026)
- Ensembl(ENSG00000284214)
- OMIM(610784)
- Open Targets Platform(ENSG00000284214)
- Search for MIR29C at DataMed
- Search for MIR29C at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29C Gene
Genomics for MIR29C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR29C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J207800 | Enhancer | 0.3 | Ensembl | 600.7 | +1.3 | 1339 | 0.4 | POLR2A | MIR29B2 MIR29C RF00017-460 CD46 MIR29B2CHG CD34 | |
| GH01J207778 | Enhancer | 0.8 | Ensembl | 12.1 | +22.8 | 22838 | 0.2 | LEF1 IKZF1 JUND MTA1 NR2C1 DPF2 HDAC1 SOX6 FOXJ2 TCF12 | MIR29C MIR29B2CHG NONHSAG004137.2 RF00017-460 CD46 CD34 | |
| GH01J207796 | Enhancer | 1 | Ensembl ENCODE | 0.7 | +3.4 | 3438 | 3.4 | CTCF JUND FOXA1 DDX20 PKNOX1 REST RAD21 BRD9 ZNF501 POLR2A | CD46 CR1L MIR29C RF00017-460 MIR29B2CHG CD34 | |
| GH01J207789 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +11.3 | 11318 | 2.6 | ATF7 ZHX2 PRDM1 CTBP1 RBM22 ATF2 GATA3 DPF2 TCF7L2 HLF | CR1L RF00017-460 MIR29C NONHSAG004137.2 CD46 MIR29B2CHG CD34 | |
| GH01J207794 | Enhancer | 0.3 | Ensembl | 0.4 | +7.6 | 7638 | 0.2 | RBM22 SUPT5H | CD46 MIR29C RF00017-460 NONHSAG004137.2 MIR29B2CHG CD34 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR29C on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR29C Gene
Genomic Locations for MIR29C Gene
- chr1:207,801,852-207,801,939
- (GRCh38/hg38)
- Size:
- 88 bases
- Orientation:
- Minus strand
- chr1:207,974,863-208,042,495
- (GRCh37/hg19)
- Size:
- 67,633 bases
- Orientation:
- Minus strand
Genomic View for MIR29C Gene
Genes around MIR29C on UCSC Golden Path with GeneCards custom track
MIR29C in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 1q32.2 by HGNC
- 1q32.2 by Entrez Gene
- 1q32.2 by Ensembl
MIR29C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR29C Gene
Proteins for MIR29C Gene
Post-translational modifications for MIR29C Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR29C
- Origene Custom Protein Services for MIR29C
No data available for DME Specific Peptides for MIR29C Gene
Domains & Families for MIR29C Gene
Gene Families for MIR29C Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29C Gene
Function for MIR29C Gene
Phenotypes From GWAS Catalog for MIR29C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 18390668 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR29C - Select products 50% OFF >
- * MIR29C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR29C
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR29C - Select products 50% OFF >
- * MIR29C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29C Gene
Localization for MIR29C Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 28159509 |
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29C Gene
Pathways & Interactions for MIR29C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Metastatic brain tumor | ||
Pathways by source for MIR29C Gene
1 BioSystems pathway for MIR29C Gene
1 KEGG pathway for MIR29C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 23936390 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 20086245 |
| GO:0010629 | negative regulation of gene expression | IDA | 20570858 |
| GO:0016525 | negative regulation of angiogenesis | IDA | 26175848 |
| GO:0030336 | negative regulation of cell migration | IDA | 23936390 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR29C Gene
Transcripts for MIR29C Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR29C Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000272A3D_9606 | miRNA | 22 | 6 |
RefSeq: NR_029832, LncBase: hsa-miR-29c-3p, miRBase: MIMAT0000681, MirGeneDB: Hsa-Mir-29-P1b_3p, TarBase: hsa-miR-29c-3p, |
| URS000075B799_9606 | precursor_RNA | 88 | 5 |
HGNC: 31621, RefSeq: NR_029832, Ensembl: ENST00000385231 (view in UCSC) , miRBase: MI0000735, |
| URS0000497496_9606 | miRNA | 22 | 5 |
RefSeq: NR_029832, LncBase: hsa-miR-29c-5p, miRBase: MIMAT0004673, TarBase: hsa-miR-29c-5p, ENA: EU154351.1:1660..1681:ncRNA, EU154352.1:1845..1866:ncRNA, LM380337.1:1..22:ncRNA, LM608662.1:16..37:ncRNA, |
| URS000042E914_9606 | precursor_RNA | 62 | 1 |
Rfam: RF00074, |
| URS0000EFC5C7_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-29-P1b, |
MIR29C in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR29C Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR29C - Select products 50% OFF >
- * MIR29C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR29C
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR29C - Select products 50% OFF >
- * MIR29C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR29C Gene
- GeneLoc Exon Structure for
- MIR29C
Expression for MIR29C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29C
Evidence on tissue expression from TISSUES for MIR29C Gene
- Blood(2.3)
- Muscle(2.2)
- Heart(2.1)
- Liver(2.1)
- Nervous system(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for MIR29C
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29C Gene
Orthologs for MIR29C Gene
No data available for Orthologs for MIR29C Gene
Paralogs for MIR29C Gene
No data available for Paralogs for MIR29C Gene
Variants for MIR29C Gene
Additional Variant Information for MIR29C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR29C
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29C Gene
Disorders for MIR29C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| huntington disease |
|
|
| rhabdomyosarcoma |
|
|
| nasopharyngeal carcinoma |
|
|
| diabetes mellitus, noninsulin-dependent |
|
|
| lung cancer |
|
Search MIR29C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR29C
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29C Gene
Publications for MIR29C Gene
- MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells. (PMID: 30513336) Cai J … Wu S (Experimental cell research 2019) 3
- LINC00511 knockdown enhances paclitaxel cytotoxicity in breast cancer via regulating miR-29c/CDK6 axis. (PMID: 31047896) Zhang H … Yu W (Life sciences 2019) 3
- miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma. (PMID: 30718452) Wu H … Liu C (Cell death & disease 2019) 3
- MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia. (PMID: 31097000) Liu B … Jia L (Journal of experimental & clinical cancer research : CR 2019) 3
- Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer. (PMID: 31497917) Han Y … Xie X (Cell proliferation 2019) 3
ExternalLinks
Products for MIR29C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR29C
- Origene Custom Protein Services for MIR29C
- Browse OriGene Inhibitory RNA Products For MIR29C
- OriGene qPCR primer pairs for MIR29C
- Browse CRISPR knockouts for MIR29C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR29C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR29C
Sources for MIR29C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB