microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR29C Gene

Subcategory (RNA class) for MIR29C Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR29C Gene

  • MicroRNA 29c 2 3 5
  • Hsa-MiR-29c-3p 166 177
  • Hsa-MiR-29c-5p 166 177
  • MIMAT0004673 51
  • MIMAT0000681 51
  • Hsa-Mir-29c 3
  • MI0000735 51
  • MiRNA29C 3
  • Mir-29c 3
  • MIRN29C 3
  • RF00074 172
  • MIR29C 2

External Ids for MIR29C Gene

Previous HGNC Symbols for MIR29C Gene

  • MIRN29C

Previous GeneCards Identifiers for MIR29C Gene

  • GC01M206043
  • GC01M207975

Summaries for MIR29C Gene

Entrez Gene Summary for MIR29C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29C Gene

MIR29C (MicroRNA 29c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29C include Huntington Disease and Rhabdomyosarcoma. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

Rfam classification for MIR29C Gene

  • mir-29 microRNA precursor

Additional gene information for MIR29C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29C Gene

Genomics for MIR29C Gene

GeneHancer (GH) Regulatory Elements for MIR29C Gene

Promoters and enhancers for MIR29C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J207800 Enhancer 0.4 Ensembl 500.7 +1.3 1339 0.4 POLR2A E2F8 AGO2 MIR29B2 MIR29C RF00017-460 MIR29B2CHG
GH01J207778 Enhancer 0.8 Ensembl 12.1 +22.8 22838 0.2 CTBP1 MEF2A HDAC3 NCOR1 NFIC ARNT POLR2H SPI1 EHMT2 TAL1 MIR29C MIR29B2CHG RF00017-460 NONHSAG004137.2 CD46
GH01J207796 Enhancer 1 Ensembl ENCODE 0.7 +3.4 3438 3.4 CTCF POLR2G JUND FOS REST RAD21 JUN TRIM22 SMC3 POLR2A CD46 CR1L MIR29C RF00017-460 MIR29B2CHG
GH01J207789 Enhancer 0.7 Ensembl ENCODE 0.4 +11.3 11318 2.6 ATF2 CTBP1 RBM22 GATA3 DPF2 HLF TCF7L2 SMARCE1 GATA2 ZHX2 CR1L RF00017-460 MIR29C NONHSAG004137.2 CD46 MIR29B2CHG
GH01J207794 Enhancer 0.4 Ensembl 0.4 +7.6 7638 0.2 RBM22 SUPT5H POLR2A CD46 RF00017-460 MIR29C NONHSAG004137.2 MIR29B2CHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR29C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR29C Gene

Genomic Locations for MIR29C Gene
chr1:207,801,852-207,801,939
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr1:207,974,863-208,042,495
(GRCh37/hg19)
Size:
67,633 bases
Orientation:
Minus strand

Genomic View for MIR29C Gene

Genes around MIR29C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29C Gene

Proteins for MIR29C Gene

Post-translational modifications for MIR29C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29C Gene

Domains & Families for MIR29C Gene

Gene Families for MIR29C Gene

genes like me logo Genes that share domains with MIR29C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR29C Gene

Function for MIR29C Gene

Phenotypes From GWAS Catalog for MIR29C Gene

Gene Ontology (GO) - Molecular Function for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18390668
genes like me logo Genes that share ontologies with MIR29C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29C Gene

Localization for MIR29C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR29C gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR29C Gene

Pathways & Interactions for MIR29C Gene

PathCards logo

SuperPathways for MIR29C Gene

genes like me logo Genes that share pathways with MIR29C: view

Pathways by source for MIR29C Gene

1 BioSystems pathway for MIR29C Gene
1 KEGG pathway for MIR29C Gene
;

Gene Ontology (GO) - Biological Process for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 23936390
GO:0008285 negative regulation of cell proliferation IDA 20086245
GO:0010629 negative regulation of gene expression IDA 20570858
GO:0016525 negative regulation of angiogenesis IDA 26175848
GO:0030336 negative regulation of cell migration IDA 23936390
genes like me logo Genes that share ontologies with MIR29C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR29C Gene

Drugs & Compounds for MIR29C Gene

No Compound Related Data Available

Transcripts for MIR29C Gene

mRNA/cDNA for MIR29C Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29C Gene

No ASD Table

Relevant External Links for MIR29C Gene

GeneLoc Exon Structure for
MIR29C

Expression for MIR29C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR29C

genes like me logo Genes that share expression patterns with MIR29C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29C Gene

Orthologs for MIR29C Gene

Evolution for MIR29C Gene

ENSEMBL:
Gene Tree for MIR29C (if available)
TreeFam:
Gene Tree for MIR29C (if available)

No data available for Orthologs for MIR29C Gene

Paralogs for MIR29C Gene

No data available for Paralogs for MIR29C Gene

Variants for MIR29C Gene

Additional dbSNP identifiers (rs#s) for MIR29C Gene

Additional Variant Information for MIR29C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29C Gene

Disorders for MIR29C Gene

MalaCards: The human disease database

(62) MalaCards diseases for MIR29C Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR29C

genes like me logo Genes that share disorders with MIR29C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29C Gene

Publications for MIR29C Gene

  1. LINC00511 knockdown enhances paclitaxel cytotoxicity in breast cancer via regulating miR-29c/CDK6 axis. (PMID: 31047896) Zhang H … Yu W (Life sciences 2019) 3 54
  2. MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia. (PMID: 31097000) Liu B … Jia L (Journal of experimental & clinical cancer research : CR 2019) 3 54
  3. Long non-coding RNA TUG1 recruits miR‑29c‑3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells. (PMID: 30720136) Wang Y … Liu A (International journal of oncology 2019) 3 54
  4. Suppressing microRNA-29c promotes biliary atresia-related fibrosis by targeting DNMT3A and DNMT3B. (PMID: 30906331) Wang JY … Yao J (Cellular & molecular biology letters 2019) 3 54
  5. High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2. (PMID: 29955039) Cappella M … Martelli F (Cell death & disease 2018) 3 54

Products for MIR29C Gene

Sources for MIR29C Gene